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GENE:

TGFBR2 (Transforming Growth Factor Beta Receptor 2)

News alerts, weekly reports and conference planners

Single-cell and spatial transcriptome analyses reveal tumor immunometabolism in lymph node metastasis of lung cancer. (PubMed, Cancer Biol Med)

This study delineated transcriptional differences between primary tumors and MetLNs in lung cancer, thereby providing a foundation for further exploration of LN metastasis.

3 days ago

Journal

GDF15 (Growth differentiation factor 15) • TGFBR2 (Transforming Growth Factor Beta Receptor 2)

Dual Administration Of Intraperitoneal And Intravenous TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy For Colorectal Cancer-Related Peritoneal Carcinomatosis: A Phase 1/2 Trial ("Chip-CRC Trial") (clinicaltrials.gov)

P1/2, N=28, Not yet recruiting, M.D. Anderson Cancer Center

5 days ago

New P1/2 trial

MSI (Microsatellite instability) • TGFBR2 (Transforming Growth Factor Beta Receptor 2)

MSI-H/dMMR

Erbitux (cetuximab) • cyclophosphamide • fludarabine IV

Ligand-dependent Wnt signaling promotes gastric cancer metastasis through hyaluronan expression in microenvironment. (PubMed, Nat Commun)

Strikingly, hyaluronidase expression in WKTP cells significantly suppresses liver metastasis. Here we show the critical role of ligand-dependent Wnt signaling and Has2-mediated hyaluronan deposition in metastasis, offering potential therapeutic strategy against gastric cancer metastasis.

8 days ago

Journal

KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • HAS2 (Hyaluronan Synthase 2)

10d

Hypoxia-Induced TGFBI Promotes Bladder Cancer Progression by Creating a Stemness Regulation Loop through Stabilizing the Disulfide Bonds of GDF15. (PubMed, Research (Wash D C))

TGFBI knockdown or GDF15 inhibition results in a decrease in functional proteins associated with stemness maintenance, which suppresses bladder CSCs' self-renewal and effectively improves the efficacy of chemotherapy. Together, these findings demonstrate the pivotal role of TGFBI in BLCA's stemness maintenance and BLCA progression, highlighting that the inhibition of the TGFBI/GDF15 axis is a potential therapeutic strategy for the amelioration of cancer chemotherapy.

10 days ago

Journal

GDF15 (Growth differentiation factor 15) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • TGFB1 (Transforming Growth Factor Beta 1) • TGFBI (Transforming Growth Factor Beta Induced)

16d

Convergence for Inactivation of TGF-β Signaling Is a Common Feature of Advanced Pancreatic Cancer. (PubMed, Cancer Discov)

No functionally deleterious driver gene mutations were identified that were attributed to treatment, although radiated PDACs had significantly greater genomic complexity and distinct mutational signatures compared to PDACs managed by chemotherapy. These findings provide a high-level profile of the genetic features distinguishing locally advanced from metastatic PDAC, potentially serving as a biomarker of borderline resectable or locally advanced PDACs most likely to benefit from neoadjuvant chemoradiation.

16 days ago

Journal

SMAD4 (SMAD family member 4) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • TGFB1 (Transforming Growth Factor Beta 1)

23d

Bile duct tumor thrombus (intraductal polypoid growth)-positive intrahepatic cholangiocarcinoma: clinicopathologic and genomic analysis. (PubMed, J Pathol)

These results highlight the importance of evaluating BDTT in SDT, as it may be the main route of hilar extension in aggressive cases.

23 days ago

Journal

KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • NRAS (Neuroblastoma RAS viral oncogene homolog) • FGFR2 (Fibroblast growth factor receptor 2) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • ARID1A (AT-rich interaction domain 1A) • NF1 (Neurofibromin 1) • BAP1 (BRCA1 Associated Protein 1) • KMT2D (Lysine Methyltransferase 2D) • MUC1 (Mucin 1) • SMAD4 (SMAD family member 4) • MLL2 (Myeloid/lymphoid or mixed-lineage leukemia 2) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • MUC4 (Mucin 4, Cell Surface Associated) • CDX2 (Caudal Type Homeobox 2) • MUC2 (Mucin 2) • RSPO3 (R-Spondin 3) • CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A) • MUC17 (Mucin 17) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K) • TGFBR1 (Transforming Growth Factor Beta Receptor 1)

FGFR2 mutation • FGFR2 fusion • FGFR2 rearrangement

26d

Curcumin attenuates the progression of hemorrhoids through the inhibition of angiogenesis via miR-190a-5p/TGFBR2. (PubMed, Sci Rep)

Mechanistically, curcumin inhibits the expression of TGFBR2 by upregulating miR-190a-5p, effectively blocking the angiogenesis ability of endothelial cells and thereby attenuating the progression and development of hemorrhoids in rats. Curcumin effectively inhibits angiogenesis in endothelial cells and relieves inflammation and the progression of hemorrhoids by regulating the miR-190a-5p/TGFBR2 molecular pathway.

26 days ago

Journal

TGFBR2 (Transforming Growth Factor Beta Receptor 2)

26d

Annurca Apple Extract and Colorectal Cancer Prevention: Preliminary In Silico Evaluation of Chlorogenic Acid. (PubMed, Diseases)

Chlorogenic acid acts as a promising multi-target ligand in CRC prevention, with our in silico evidence supporting its ability to modulate diverse oncogenic pathways. Further experimental studies are warranted to confirm its efficacy and translational potential.

26 days ago

Journal

KDR (Kinase insert domain receptor) • FLT1 (Fms-related tyrosine kinase 1) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • CXCR2 (Chemokine (C-X-C motif) receptor 2)

chlorogenic acid

Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma. (PubMed, Sci Adv)

Although TGFβ ligands can potently induce growth arrest in cells of epithelial origin, we show that TGFβ1 and TGFβ2 promote cell invasion of EwS cells without affecting proliferation. Thus, stroma-derived and tumor-derived TGFβ ligands induce and maintain hybrid EwS cells to promote pro-metastatic cell phenotypes.

1 month ago

Journal

TGFBR2 (Transforming Growth Factor Beta Receptor 2) • FLI1 (Fli-1 Proto-Oncogene ETS Transcription Factor) • TGFB1 (Transforming Growth Factor Beta 1) • TGFB2 (Transforming Growth Factor Beta 2)

Using transcriptomics and molecular docking to uncover the pharmacological targets and its associated biological mechanisms of paeoniflorigenone in treating bladder cancer. (PubMed, Discov Oncol)

It was initially discovered that PAG exerts its therapeutic effects on bladder cancer by targeting multiple pathways and multiple targets. This finding will enhance our comprehension of the potential mechanism by which PAG combats bladder cancer, and it will serve as a theoretical foundation for future research endeavors.

1 month ago

Journal

TOP2A (DNA topoisomerase 2-alpha) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • IL17A (Interleukin 17A) • MMP9 (Matrix metallopeptidase 9) • MMP1 (Matrix metallopeptidase 1) • PRSS1 (Serine Protease 1) • MMP14 (Matrix Metallopeptidase 14) • MMP7 (Matrix metallopeptidase 7)

IL7-TBRII, a Dual Cytokine Modulator Targeting IL-7 and TGF-β Pathways, Inhibits Tumor Progression and Metastasis. (PubMed, Immune Netw)

As TGF-β impairs CD8+ T cell function and antagonizes IL-7 signaling, we developed a bifunctional fusion protein, recombinant human IL-7 (rhIL-7)-hyFc-sTBRII (IL7-TBRII), by fusing a TGF-β trap (Fc-TBRII) to rhIL-7-hyFc (IL7-Fc)...Furthermore, IL7-TBRII reduced metastasis in the 4T1 breast cancer model by reshaping the immune cell composition, and demonstrated synergistic efficacy when combined with radiotherapy or anti-CTLA-4 therapy in the EMT6 breast tumor model. These findings suggest that dual modulation of the IL-7 and TGF-β pathways by IL7-TBRII effectively reprograms the immune microenvironment in both primary and metastatic tumors, particularly by promoting CD8+ T cell activation and infiltration, thus offering a promising strategy to improve clinical responses to immunotherapy.

1 month ago

Journal

CD8 (cluster of differentiation 8) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • TGFB1 (Transforming Growth Factor Beta 1) • IL7 (Interleukin 7)

Hyleukin-7 (efineptakin alfa)

2ms

STC2+ Malignant Cell State Associated with EMT, Tumor Microenvironment Remodeling, and Poor Prognosis Revealed by Single-Cell and Spatial Transcriptomics in Colorectal Cancer. (PubMed, Oncol Res)

This study identified a malignant cell state in CRC that is metabolically defined and spatially limited, including liver metastases, and is characterized by elevated STC2 expression and active immune-stromal interactions. Given the interplay between metabolic reprogramming and TME remodeling, STC2+ malignant cells are a functionally significant subpopulation and a potential therapeutic target.

2 months ago

Journal

CD74 (CD74 Molecule) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • GDF15 (Growth differentiation factor 15) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • STC2 (Stanniocalcin 2)