TFRC

Moreover, 6-OHDA induces distinct inflammatory responses depending on the stage of oligodendrocyte differentiation. These findings highlight the dual role of oligodendrocytes as both iron reservoirs and modulators of the neuroinflammatory microenvironment, providing new insights into the cellular mechanisms underlying nigral iron accumulation in PD, and suggesting that oligodendrocytes play a critical regulatory role in PD pathogenesis.

In vivo, APOE overexpression in a mouse xenograft model resulted in significantly smaller tumors, with changes in autophagy and ferroptosis markers consistent with in vitro findings. APOE overexpression suppresses osteosarcoma growth by promoting ferroptosis and autophagy through the mTOR/Stat3 signaling pathway, highlighting its promise as a target for OS therapeutic intervention.

Vas2870 prevents myocyte ferroptosis through inhibition of lipid peroxidation, GPX4/SLC7A11 downregulation and disruptions in iron metabolism, leading to the amelioration of doxorubicin-induced heart failure. Therapies directed at inhibiting NADPH oxidase and/or ferroptosis may be of value in the treatment of heart failure.

BaSO4NPs provoked severe hepatic impairments by altering biochemical, computational and histological parameters. The concurrent therapy of AYN mitigated the adverse impacts of BaSO4NPs on hepatic tissues through the regulation of key signaling pathways, redox state, inflammatory and apoptotic indices, and histological alterations.

Before the first TKI discontinuation, all six patients had received imatinib treatment for a median of 82.5 months (range, 40-87 months) and maintained a sustained deep molecular response, specifically MR(4.5), for a median of 34.5 months (range, 24-62 months)...All four patients who had resumed TKI treatment for >6 years and maintained MR(4.5) for >5 years achieved a sustained second TFR of ≥21 months; among these, three had received second-generation TKI for >1 year during the resumption of TKI treatment. The other two patients lost MMR at 4 and 3 months, respectively, after the second TKI discontinuation but regained MR(4.5) at 2 and 3 months, respectively, after resuming TKI treatment again.

Antimicrobial screening indicated negligible activity, supporting desirable selectivity toward tumour cells. Altogether, this multimodal experimental-computational study demonstrates that (alkyl-ω-ol)triphenyltin(IV) complexes exert anticancer effects through a combination of direct cytotoxic mechanisms and Tf-assisted protein binding pathways, providing a basis for the rational development of organotin(IV)-based metallodrugs with improved selectivity.

Cisplatin (DDP) is the first-in-class drug for advanced and non-targetable non-small-cell lung cancer (NSCLC). However, the effects were reversed by ferroptosis inhibitor ferrostatin-1 or deferoxamine in NSCLC cells. In summary, these results provide in vitro experimental evidence that PEM boosts the antitumor activity and increases the sensitivity of NSCLC cells to DDP by inducing ferroptosis.

Our results indicate a promising and efficient strategy for the encapsulation and targeted delivery of venetoclax using HFn nanoparticles for AML patients. This delivery system can support co-delivery of various drugs and combination therapy of tumor cells.

Further functionalization with an RGD peptide enhanced glioblastoma-targeted cellular uptake, and DOX-loaded RGD-D44A nanocages demonstrated potent antitumor efficacy in vivo. Collectively, these findings establish a rational mutation-based approach to fine-tune channel-adjacent interfacial dynamics, providing a generalizable framework for thermoresponsive macromolecular carrier design.

Altogether, these findings reveal that the metastatic bone marrow niche is not static; it is a highly dynamic, multi-lineage ecosystem. By mapping these intricate cellular interactions, we argue for a paradigm shift: targeting these early and cooperative crosstalk, whether through glycoprotein-A repetitions predominant (GARP) blockade, metabolic reprogramming, or other niche-disruptive strategies, could unlock new therapeutic avenues and prevent metastatic relapse at its root.

Importantly, n(ch128.1Av/b-SO6)-CXCL13 demonstrated antitumor efficacy in an AIDS-associated NHL xenograft mouse model. Taken together, our results suggest that n(ch128.1Av/b-SO6)-CXCL13, or similar proimmunotoxin strategies, represents a promising therapeutic avenue for AIDS-NHL and potentially other malignancies.

Under laser irradiation, the leaked deoxyhemoglobin significantly enhanced the photothermal effect and subsequently triggered anti-tumor immune responses. The cavities of ferritin nanocages can further encapsulate drugs, endowing them with broader application prospects.