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    GENE:

    TFG (Trafficking From ER To Golgi Regulator)

    i
    Other names: TFG, Trafficking From ER To Golgi Regulator, TRK-Fused Gene Protein, Protein TFG, SPG57, TF6, TRK-Fused Gene, TRKT3 Oncogene, TRK-Fused, FLJ36137, HMSNP, TRKT3
    5ms
    Elevated FBXO45 promotes TFG ubiquitination and drives lung metastasis of hepatocellular carcinoma. (PubMed, JHEP Rep)
    FBXO45 promotes HCC lung metastasis by activating the TFG-ATF2-NF-κB-epithelial-mesenchymal transition signaling axis. In addition, we found that targeting the TP53-FBXO45-TFG-ATF2-NF-κB axis could be a novel approach for the treatment of metastatic HCC.
    Journal
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    TP53 (Tumor protein P53) • TFG (Trafficking From ER To Golgi Regulator) • ATF2 (Activating Transcription Factor 2) • RELA (RELA Proto-Oncogene)
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    TP53 mutation
    1year
    A TaqMan-Based qRT-PCR Assay for Accurate Evaluation of the Oncogenic TrkAIII Splice Variant in Tumor cDNAs. (PubMed, Cancers (Basel))
    It is highly efficient, reproducible, and specific and can detect as few as 10 TrkAIII copies in complex RNAs extracted from either fresh or FFPE tumor tissues. Inclusion of this assay into precision oncology algorithms, when paired with fs-TrkA qRT-PCR and TrkA immune histochemistry, will make it easier to identify patients with therapy-resistant, advanced-stage metastatic Trk-fused gene-negative tumors potentially driven by TrkAIII, for whom approval of third-line effective Trk inhibitors could be extended.
    Journal
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    NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • TFG (Trafficking From ER To Golgi Regulator)
    1year
    NTRK fusion promotes tumor migration and invasion through epithelial-mesenchymal transition and closely interacts with ECM1 and NOVA1. (PubMed, BMC Cancer)
    NTRK fusion tumors present heightened migratory and invasive potential in clinical settings. Further experiments confirmed the significant inhibitory effects of TRK inhibitors on the migration and invasion abilities of these cells. There is a complex relationship between ECM1, NOVA1 and NTRK fusion; however, further research is needed to determine whether NTRK fusion promotes tumor metastasis through these two genes.
    Journal
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    TFG (Trafficking From ER To Golgi Regulator) • NTRK (Neurotrophic receptor tyrosine kinase)
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    NTRK positive • NTRK expression • NTRK fusion
    over1year
    NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitors. (PubMed, Acta Neuropathol Commun)
    Four patients received adjuvant TRK inhibitor therapy (larotrectinib, repotrectinib, or entrectinib), among which three also received chemotherapy (n = 2) or proton therapy (n = 1). This patient had previously experienced relapse after the initial surgery and underwent autologous peripheral blood stem cell therapy with carboplatin/thiotepa and proton therapy. Conclusions Our study clarifies the distinct differences in the pathology and TRK inhibitor response between LGG and HGG with NTRK fusions.
    Journal
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    TP53 (Tumor protein P53) • PTEN (Phosphatase and tensin homolog) • NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • TERT (Telomerase Reverse Transcriptase) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • MDM4 (The mouse double minute 4) • TPM3 (Tropomyosin 3) • TFG (Trafficking From ER To Golgi Regulator) • FKBP15 (FKBP Prolyl Isomerase 15) • KANK1 (KN Motif And Ankyrin Repeat Domains 1) • NTRK (Neurotrophic receptor tyrosine kinase) • SPECC1L (Sperm Antigen With Calponin Homology And Coiled-Coil Domains 1 Like) • GKAP1 (G Kinase Anchoring Protein 1) • KIF5A (Kinesin Family Member 5A)
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    carboplatin • Vitrakvi (larotrectinib) • Rozlytrek (entrectinib) • Augtyro (repotrectinib) • thiotepa
    over1year
    Beyond Clinical Trials: Understanding Neurotrophic Tropomyosin Receptor Kinase Inhibitor Challenges and Efficacy in Real-World Pediatric Oncology. (PubMed, JCO Precis Oncol)
    This real-world study confirms favorable agnostic tumor OR rates to larotrectinib in children with NTRK-fused tumors. Better coordination to facilitate access to medication remains a challenge, particularly in middle-income countries like Brazil.
    Journal • Real-world evidence • Real-world
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    TFG (Trafficking From ER To Golgi Regulator) • NTRK (Neurotrophic receptor tyrosine kinase)
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    Vitrakvi (larotrectinib)
    almost2years
    ETV6::NTRK3 Fusion-Positive Wild-Type Gastrointestinal Stromal Tumor (GIST) with Abundant Lymphoid Infiltration (TILs and Tertiary Lymphoid Structures): A Report on a New Case with Therapeutic Implications and a Literature Review. (PubMed, Int J Mol Sci)
    The follow-up CT scan revealed peritoneal nodules suggestive of peritoneal dissemination, and Entrectinib (a TRK inhibitor) was administered...The present case may offer new insights into the potential introduction of TRK inhibitors as treatments for GISTs with NTRK fusions. Additionally, the presence of abundant lymphoid infiltration in the present case may prompt further research into immunotherapy as a possible additional therapeutic option.
    Clinical • Observational data • Retrospective data • Review • Journal • IO biomarker • Stroma
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    KIT (KIT proto-oncogene, receptor tyrosine kinase) • NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3) • RB1 (RB Transcriptional Corepressor 1) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • ETV6 (ETS Variant Transcription Factor 6) • SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B) • TFG (Trafficking From ER To Golgi Regulator) • NTRK (Neurotrophic receptor tyrosine kinase) • ANO1 (Anoctamin 1)
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    NTRK3 fusion • RB1 mutation • PDGFRA mutation • NTRK3 positive • NTRK fusion
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    Rozlytrek (entrectinib)
    almost3years
    A Case of Infant-type Hemispheric Glioma with NTRK1 fusion (AAN 2023)
    Mixed-age hemorrhages and diffusion restriction is suggestive of the diagnosis. The neurotrophic tyrosine receptor kinase (NTRK) genes NTRK1, NTRK2, and NTRK3 are involved in infant-type hemispheric gliomas and are typically high grade in histology. A recent study by Torre et al. showed most NTRK-fused gliomas were hemispheric and had a higher prevalence in non-brainstem high grade gliomas in patients younger than 3 years old.
    Clinical
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    NTRK1 (Neurotrophic tyrosine kinase, receptor, type 1) • NTRK3 (Neurotrophic tyrosine kinase, receptor, type 3) • NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • TFG (Trafficking From ER To Golgi Regulator) • NTRK (Neurotrophic receptor tyrosine kinase)
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    NTRK1 fusion • NTRK fusion
    3years
    ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4 expression. (PubMed, Proc Natl Acad Sci U S A)
    We show that Signal transducer and activator of transcription 3 (STAT3), Nuclear Factor Kappa B (NF-κB) and Activator protein 1 (AP1) are major transcriptional regulators of SERPINB4 downstream of ALK fusions. Upregulation of SERPINB4 promotes survival and inhibits natural killer cell-mediated cytotoxicity, which has potential for therapeutic impact targeting the immune response together with ALK TKIs in NSCLC.
    Journal
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    ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4) • KIF5B (Kinesin Family Member 5B) • STAT3 (Signal Transducer And Activator Of Transcription 3) • TFG (Trafficking From ER To Golgi Regulator) • SERPINB4 (Serpin Family B Member 4)
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    ALK positive • ALK fusion
    3years
    TRK Protein Expression in Merkel Cell Carcinoma Is Not Caused by NTRK Fusions. (PubMed, Int J Mol Sci)
    Despite 34 MCCs showing pan-TRK expression, NTRK fusions were not found in any cases. As in other tumors with neural differentiation, TRK expression seems to be physiological and not caused by gene fusions.
    Journal
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    TFG (Trafficking From ER To Golgi Regulator) • NTRK (Neurotrophic receptor tyrosine kinase)
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    NTRK expression • NTRK fusion