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GENE:

TFAP2C (Transcription Factor AP-2 Gamma)

News alerts, weekly reports and conference planners

TFAP2C protects against ferroptosis in ovarian cancer through the KEAP1-NRF2 axis by recruiting HDAC1/2. (PubMed, Oncogene)

In summary, our mechanistic investigations revealed TFAP2C as a novel oncogenic driver in OC and a key regulator of ferroptosis via its epigenetic modulation of the KEAP1-NRF2 axis. These findings highlight TFAP2C as a potential therapeutic target for ferroptosis-inducing therapies in OC patients with high TFAP2C expression.

5 days ago

Journal

KEAP1 (Kelch Like ECH Associated Protein 1) • HDAC1 (Histone Deacetylase 1) • TFAP2A (Transcription Factor AP-2 Alpha) • TFAP2C (Transcription Factor AP-2 Gamma)

Propofol attenuates angiogenesis by activating endoplasmic reticulum stress to suppress TFAP2C-driven VEGFA transcription. (PubMed, Apoptosis)

Further analysis revealed that TFAP2C directly binds to the VEGFA promoter to activate its transcription, thereby facilitating VEGFA/VEGFR2-dependent angiogenesis. Together, these findings not only broaden the understanding of propofol's pharmacological profile, but also identify TFAP2C as a novel transcriptional regulator of VEGFA, offering new perspectives for therapeutic targeting of VEGFA-mediated angiogenesis.

1 month ago

Journal

VEGFA (Vascular endothelial growth factor A) • TFAP2A (Transcription Factor AP-2 Alpha) • TFAP2C (Transcription Factor AP-2 Gamma)

3ms

Identification of a Treg-related gene signature for predicting prognosis and immunosuppression in skin cutaneous melanoma. (PubMed, Clin Exp Med)

qRT-PCR and Western blot confirmed PTPRF, ULK1, TGM3, and CRABP2 were upregulated at both the mRNA and protein levels. These findings indicate that the Treg-related signature serves as robust prognostic biomarkers and may guide personalized immunotherapy in SCKM.

3 months ago

Journal • Gene Signature • IO biomarker

HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1) • NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • PTPRF (Receptor-type tyrosine-protein phosphatase F) • CRIP1 (Cysteine Rich Protein 1) • KHDRBS3 (KH RNA Binding Domain Containing, Signal Transduction Associated 3) • MIR375 (MicroRNA 375) • TFAP2A (Transcription Factor AP-2 Alpha) • TFAP2C (Transcription Factor AP-2 Gamma) • HLA-DQB2 (Major Histocompatibility Complex, Class II, DQ Beta 2)

4ms

Genetic regulation of the estrogen receptor and inherited predisposition to breast cancer. (PubMed, Proc Natl Acad Sci U S A)

At the site with the most striking effect, the breast-cancer-linked allele was associated with increased binding by transcription factor AP2-gamma TFAP2C in both MCF7 and T47D cells. These results demonstrate coinheritance with breast cancer of rare alleles that increase activity of ESR1 promoters, and suggest that rare ESR1 regulatory alleles may contribute to inherited predisposition to breast cancer.

4 months ago

Journal

ER (Estrogen receptor) • TFAP2A (Transcription Factor AP-2 Alpha) • TFAP2C (Transcription Factor AP-2 Gamma)

4ms

Deficiency of DAZ genes links testicular germ cell tumorigenesis and infertility: evidence from human embryonic stem cell germline differentiation. (PubMed, Am J Cancer Res)

Using a human in vitro model, this study links DAZ deficiency to both infertility and TGCT susceptibility and identifies HMGA1 as a central transcriptional-signaling hub. This finding provides molecular clues for risk stratification and early surveillance in populations with DAZ deficiency and suggests that interventions targeting HMGA1 and the PI3K/AKT and MAPK pathways may simultaneously improve germline differentiation and reduce potential tumor risk.

4 months ago

Journal

SOX17 (SRY-Box Transcription Factor 17) • PRDM1 (PR/SET Domain 1) • TFAP2A (Transcription Factor AP-2 Alpha) • TFAP2C (Transcription Factor AP-2 Gamma)

5ms

A genome-wide analysis of YY1 and TFAP2 competition on overlapping motifs reveals their roles in HPV-induced carcinogenesis. (PubMed, PLoS Pathog)

This suggests that YY1 and TFAP2 competition might influence a broader transcriptional regulation network in HPV-induced cancer. This study reveals a novel transcriptional antagonism mechanism affecting lnc-FANCI-2 and other cancer-related genes, highlighting YY1 and TFAP2 as potential therapeutic targets in HPV-driven carcinogenesis.

5 months ago

Journal

FANCI (FA Complementation Group I) • PPP1R15B (Protein Phosphatase 1 Regulatory Subunit 15B) • TFAP2A (Transcription Factor AP-2 Alpha) • TFAP2C (Transcription Factor AP-2 Gamma) • YY1 (YY1 Transcription Factor)

6ms

Menin facilitates the cell proliferation of bladder cancer via modulating the TFAP2C/β-catenin axis. (PubMed, Genes Dis)

Our current work unveils an important role of the menin in triggering the TFAP2C/β-catenin axis, which contributes to cell proliferation of BLCA cells. Therefore, menin might be served as a new therapeutic target for BLCA.

6 months ago

Journal

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MEN1 (Menin 1) • TFAP2A (Transcription Factor AP-2 Alpha) • TFAP2C (Transcription Factor AP-2 Gamma)

7ms

TFAP2C activates PTGES through the NOTCH3 signaling pathway to affect gefitinib resistance in lung adenocarcinoma. (PubMed, J Clin Biochem Nutr)

Furthermore, overexpressing PTGES upon the TFAP2C silence restored the great inhibition effect conferred by TFAP2C silence in PC-9/GR cells on cell viability and cell response to gefitinib resistance. This study confirmed that TFAP2C can transcriptionally activate PTGES through the NOTCH3 signaling pathway to enhance the response of LUAD cells to gefitinib resistance, proffering a new approach for the treatment of gefitinib resistance in LUAD cells.

7 months ago

Journal

NOTCH3 (Notch Receptor 3) • PTGES (Prostaglandin E Synthase) • TFAP2A (Transcription Factor AP-2 Alpha) • TFAP2C (Transcription Factor AP-2 Gamma)

gefitinib

7ms

The chimeric aptamer axl-miR-214sponge inhibits breast cancer and melanoma dissemination. (PubMed, Mol Ther)

In summary, our data suggest that axl-miR-214sponge is specific, effective and safe in blocking axl-positive cancer cell spreading. Thus, it represents a promising targeted therapy tool to fight metastasis.

7 months ago

Journal

AXL (AXL Receptor Tyrosine Kinase) • ALCAM (Activated Leukocyte Cell Adhesion Molecule) • NTRK (Neurotrophic receptor tyrosine kinase) • ITGA3 (Integrin Subunit Alpha 3) • MIR148B (MicroRNA 148b) • MIR214 (MicroRNA 214) • TFAP2A (Transcription Factor AP-2 Alpha) • TFAP2C (Transcription Factor AP-2 Gamma)

AXL positive

7ms

TFAP2C Affects PI3K/AKT/mTOR Pathway-Mediated EMT for Glioblastoma Development Through Transcriptional Regulation. (PubMed, Cell Biol Int)

Finally, the in vitro results were further validated in animal experiments. In conclusion, TFAP2C promotes PI3K transcription through direct binding to the promoter of PI3K and activates the PAM pathway to promote GBM proliferation and EMT, providing a potential therapeutic target for GBM.

7 months ago

Journal

CDH1 (Cadherin 1) • VIM (Vimentin) • CDH2 (Cadherin 2) • TJP1 (Tight Junction Protein 1) • TFAP2A (Transcription Factor AP-2 Alpha) • TFAP2C (Transcription Factor AP-2 Gamma)

7ms

Combining decitabine with radiotherapy to enhance nasopharyngeal carcinoma radiosensitivity via the TFAP2C-OTUD1-SLC25A11 axis. (PubMed, Cell Death Dis)

Furthermore, we demonstrate that combining the methylation inhibitor Decitabine (DAC) with radiotherapy significantly improves treatment efficacy by overcoming radioresistance. These findings provide insights into NPC radioresistance and suggest that using DAC in combination with radiotherapy to target the TFAP2C-OTUD1-SLC25A11 axis could be a promising strategy to overcome radioresistance.

7 months ago

Journal

OTUD1 (OTU Deubiquitinase 1) • TFAP2A (Transcription Factor AP-2 Alpha) • TFAP2C (Transcription Factor AP-2 Gamma)

decitabine