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    BIOMARKER:

    TET1 mutation

    i
    Other names: TET1, Tet Methylcytosine Dioxygenase 1, Leukemia-Associated Protein With A CXXC Domain, Ten-Eleven Translocation 1 Gene Protein, Methylcytosine Dioxygenase TET1, CXXC-Type Zinc Finger Protein 6, Ten-Eleven Translocation-1, CXXC Zinc Finger 6, Tet Oncogene 1, CXXC6, TET1 Splice Variant VP_DE456, TET1 Splice Variant VP_DE4, CXXC Finger 6
    Entrez ID:
    80312
    over1year
    TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype. (PubMed, Gastroenterology)
    Our findings reveal a novel epigenetic regulation, linked to the type of genomic instability, by which TET1/TDG-mediated DNA demethylation decreases methylation levels and inflammatory/interferon/immune responses. CIMP in CRC is triggered by an imbalance of methylating activities over demethylating activities. These mice represent a model of CIMP CRC.
    Journal
    |
    APC (APC Regulator Of WNT Signaling Pathway) • TET1 (Tet Methylcytosine Dioxygenase 1) • DNMT1 (DNA methyltransferase 1) • TDG (Thymine DNA Glycosylase)
    |
    APC mutation • TET1 mutation • DNMT1 expression
    over2years
    TET1 mutations as a predictive biomarker for immune checkpoint inhibitors in colon adenocarcinoma. (PubMed, World J Surg Oncol)
    These findings suggest that TET1 mutations may serve as a potential biomarker for the response to ICIs in COAD patients.
    Journal • Checkpoint inhibition • Tumor Mutational Burden • IO biomarker
    |
    TMB (Tumor Mutational Burden) • TET1 (Tet Methylcytosine Dioxygenase 1)
    |
    TET1 mutation
    |
    5-fluorouracil • lapatinib
    over3years
    TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice. (PubMed, Nat Commun)
    Zebrafish mutants for slc12a2b also display swellings of CNS myelinated axons. Our findings suggest that TET1 is required for adult myelin repair and regulation of the axon-myelin interface.
    Preclinical • Journal
    |
    TET2 (Tet Methylcytosine Dioxygenase 2) • TET1 (Tet Methylcytosine Dioxygenase 1) • SLC12A2 (Solute Carrier Family 12 Member 2)
    |
    TET1 mutation
    over3years
    Tet1 is not required for myeloid leukemogenesis by MLL-ENL in novel mouse models. (PubMed, PLoS One)
    In addition, the leukemic phenotypes caused by the induced expression of MLL-ENL in vivo was not also critically affected in the compound mutant mouse model by conditional ablation of Tet1, although we found that the expression of Evi1, which is one of critical target genes of MLL fusion gene, in tumor cells was remarkably low under Tet1-ablated condition. These results revealed that Tet1 was dispensable for the myeloid leukemogenesis by MLL-ENL, suggesting that the therapeutic application of Tet1 inhibition may need careful assessment.
    Preclinical • Journal
    |
    TET2 (Tet Methylcytosine Dioxygenase 2) • TET1 (Tet Methylcytosine Dioxygenase 1)
    |
    TET2 mutation • TET1 mutation • MLL fusion
    over3years
    [VIRTUAL] TET1 mutation as potential biomarker for immune checkpoint blockade in colorectal cancer (AACR 2021)
    TET1 mutation was strongly associated with higher TMB, MSI-H and PD-L1 expression and improved OS in patients receiving immune checkpoint blockade treatment, suggesting that TET1 mutation is a novel predictive biomarker for immunotherapy in colorectal cancer.
    Checkpoint inhibition • Tumor Mutational Burden • MSi-H Biomarker • PD(L)-1 Biomarker • IO biomarker
    |
    TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • TET1 (Tet Methylcytosine Dioxygenase 1)
    |
    PD-L1 expression • TMB-H • MSI-H/dMMR • TET1 mutation