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    GENE:

    TENM4 (Teneurin Transmembrane Protein 4)

    i
    Other names: TENM4, Teneurin Transmembrane Protein 4, Ten-M4, Protein Odd Oz/Ten-M Homolog 4, Tenascin-M4, Teneurin-4, KIAA1302, Ten-4, ODZ4, TEN4, TNM4, Odz Odd Oz/Ten-M Homolog 4 (Drosophila), Odz Odd Oz/Ten-M Homolog 4, TENM4, Doc4, ETM5
    2ms
    Transcript Imbalance from TENM4 Exon Skipping: Effects on Epilepsy and Genetic Pleiotropy. (PubMed, Mol Neurobiol)
    Homozygous Tenm4ΔE10/ΔE10 mice exhibited significantly increased susceptibility to pentylenetetrazole-induced seizures...An imbalance in the proportion can impair oligodendrocyte development, causing structural brain abnormalities and seizure susceptibility. In conclusion, our findings successfully elucidated a novel pathomechanism that emphasized the role of transcript isoform imbalance in neurodevelopmental diseases and expanded the pleiotropic condition of TENM4.
    Journal
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    TENM4 (Teneurin Transmembrane Protein 4)
    2ms
    Transposable Element-Derived miR-28-5p and miR-708-5p: Exploring Potential Roles in Lung Cancer. (PubMed, Noncoding RNA)
    Furthermore, we emphasize that miR-28 and miR-708 might contribute to lung cancer pathogenesis by targeting key tumor suppressor genes. Alterations in the methylation status of L2-miRNAs genomic loci might result in elevated levels of miRNAs and subsequent targeting of tumor suppressor genes with potential implications in lung cancer pathogenesis.
    Journal
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    TENM4 (Teneurin Transmembrane Protein 4) • MIR708 (MicroRNA 708)
    11ms
    Radiomics-clinical nomogram for preoperative tumor-node-metastasis staging prediction in breast cancer patients using dynamic enhanced magnetic resonance imaging. (PubMed, Transl Cancer Res)
    Compared to traditional imaging methods, the clinical-radiomics nomogram acquired by DCE-MRI could potentially be utilized to preoperatively evaluate the TNM stage of breast cancer with relatively high accuracy. It can be an effective method to guide clinical decisions.
    Journal
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    TENM4 (Teneurin Transmembrane Protein 4)
    11ms
    Identifying a unique chromosomal pattern to predict the gemcitabine response in patients with cholangiocarcinoma. (PubMed, Sci Rep)
    Although gemcitabine (GEM) and cisplatin (CIS) are the current gold-standard for treating unresectable CCA, GEM resistance often occurs. High signal of CDH13 and TENM4 were demonstrated in GEM non-response, while a high CWC27 signal was noted in GEM response. This signature pattern could provide the knowledge to improve a predictive biomarker for GEM response, benefitting for individual CCA patient management and chemotherapeutic selection.
    Journal
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    TENM4 (Teneurin Transmembrane Protein 4)
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    cisplatin • gemcitabine
    1year
    Integrated single-cell and bulk RNA sequencing reveals immune-related SPP1+ macrophages as a potential strategy for predicting the prognosis and treatment of liver fibrosis and hepatocellular carcinoma. (PubMed, Front Immunol)
    Moreover, 6 potential small molecule drugs for the treatment of liver fibrosis and HCC were provided. The comprehensive investigation, based on a bioinformatics and mouse model strategy, may identify pathogenic genes, cell subsets, regulatory mechanisms, prognostic genes, and potential small molecule drugs, thereby providing valuable insights into the clinical prognosis and targeted treatment of liver fibrosis and HCC.
    Journal
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    SPP1 (Secreted Phosphoprotein 1) • CCR7 (Chemokine (C-C motif) receptor 7) • COL3A1 (Collagen Type III Alpha 1 Chain) • TENM4 (Teneurin Transmembrane Protein 4)
    over1year
    Identifying crucial lncRNAs and mRNAs in hypoxia-induced A549 lung cancer cells and investigating their underlying mechanisms via high-throughput sequencing. (PubMed, PLoS One)
    Our findings suggest a potential involvement of SNAP25-AS1, RP11-58O9.2, TENM4, XRCC2, LINC01164, VLDLR-AS1, RP11-14I17.2, and CDKN1A in the development of hypoxia-induced lung cancer. These key lncRNAs and mRNAs exert their functions through diverse mechanisms, including the competitive endogenous RNA (ceRNA) pathway.
    Journal
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    XRCC2 (X-Ray Repair Cross Complementing 2) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • TENM4 (Teneurin Transmembrane Protein 4)
    over1year
    Targeted panel sequencing of pharmacogenes and oncodrivers in colorectal cancer patients reveals genes with prognostic significance. (PubMed, Hum Genomics)
    The present study identified several putative somatic and germline genetic events with prognostic potential for colorectal cancer that should undergo functional characterization.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • LRP1B (LDL Receptor Related Protein 1B) • FBXW7 (F-Box And WD Repeat Domain Containing 7) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • FAT4 (FAT Atypical Cadherin 4) • RYR1 (Ryanodine Receptor 1) • GLI3 (GLI Family Zinc Finger 3) • COL6A3 (Collagen Type VI Alpha 3 Chain) • NAV3 (Neuron Navigator 3 ) • RIF1 (Replication Timing Regulatory Factor 1) • TENM4 (Teneurin Transmembrane Protein 4) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • FLG (Filaggrin) • RYR3 (Ryanodine Receptor 3) • ABCA13 (ATP Binding Cassette Subfamily A Member 13) • TCHH (Trichohyalin)
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    5-fluorouracil
    almost2years
    Ergosterol promotes neurite outgrowth, inhibits amyloid-beta synthesis, and extends longevity: In vitro neuroblastoma and in vivo Caenorhabditis elegans evidence. (PubMed, Life Sci)
    Ergosterol is a potential candidate compound that might benefit AD patients by promoting neurite outgrowth, inhibiting Aβ synthesis, and enhancing longevity.
    Preclinical • Journal
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    TENM4 (Teneurin Transmembrane Protein 4)
    almost2years
    Dysregulation of the Skin-Liver Axis in Prurigo Nodularis: An Integrated Genomic, Transcriptomic, and Population-Based Analysis. (PubMed, Genes (Basel))
    A subsequent genome-wide association study (GWAS) identified shared single-nucleotide polymorphisms (SNPs) in the genes AR, EDIL3, MACROD2, PCSK5, RUNX1T1, TENM4, and ZEB2 between PN and liver disease from the FinnGen cohort. Significant dysregulation of the skin-liver axis in PN patients may explain the increased incidence and severity of hepatic comorbidities and help identify future therapeutic targets for PN.
    Journal
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    RUNX1T1 (RUNX1 Partner Transcriptional Co-Repressor 1) • TENM4 (Teneurin Transmembrane Protein 4) • ZEB2 (Zinc Finger E-Box Binding Homeobox 2) • EDIL3 (EGF Like Repeats And Discoidin Domains 3)
    over2years
    Clinical and genetic characteristics in pancreatic cancer from Chinese patients revealed by whole exome sequencing. (PubMed, Front Oncol)
    The TMB index was higher in patients with mutant-type KRAS MUT/TP53 MUT (p < 0.001), CDKN2A (p = 0.547), or SMAD4 (p = 0.064) compared to patients with wild-type KRAS/TP53, CDKN2A, or SMAD4. We exhibited real-world genetic traits and new alterations in Chinese individuals with cancer of the pancreas, which might have interesting implications for future individualized therapy and medication development.
    Journal • Tumor mutational burden • BRCA Biomarker • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • TMB (Tumor Mutational Burden) • BRCA1 (Breast cancer 1, early onset) • FGFR3 (Fibroblast growth factor receptor 3) • ATM (ATM serine/threonine kinase) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • ARID1A (AT-rich interaction domain 1A) • PALB2 (Partner and localizer of BRCA2) • RNF43 (Ring Finger Protein 43) • SMAD4 (SMAD family member 4) • GAS6 (Growth arrest specific 6) • MMP17 (Matrix Metallopeptidase 17) • WRN (WRN RecQ Like Helicase) • TENM4 (Teneurin Transmembrane Protein 4) • MMP7 (Matrix metallopeptidase 7) • USP7 (Ubiquitin Specific Peptidase 7)
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    PD-L1 expression • TP53 mutation • KRAS mutation • ATM mutation • PALB2 mutation • KRAS wild-type • RAS wild-type • SMAD4 mutation • FGFR3 fusion • WRN mutation
    3years
    Han family with essential tremor caused by the P421L variant of the TENM4 gene in China. (PubMed, Neurol Sci)
    This study revealed that the TENM4 (p.P421L) pathogenic missense variation was responsible for ET in the proband.
    Journal
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    SORT1 (Sortilin 1) • FUS (FUS RNA Binding Protein) • TENM4 (Teneurin Transmembrane Protein 4) • CNPY2 (Canopy FGF Signaling Regulator 2)
    over3years
    RNA-Seq transcriptome analysis reveals Maackia amurensis leukoagglutinin has antitumor activity in human anaplastic thyroid cancer cells. (PubMed, Mol Biol Rep)
    Collectively, our results show that MAL-II treatment reveals significant antitumor activity by changing the expression of many cancer-related genes and implies that MAL-II treatment might be a potential candidate molecule to inhibit the malignancy of human anaplastic thyroid cancer.
    Journal
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    TNFAIP3 (TNF Alpha Induced Protein 3) • G0S2 (G0/G1 Switch 2) • HSPA6 (Heat Shock Protein Family A (Hsp70) Member 6) • TENM4 (Teneurin Transmembrane Protein 4) • ARRB1 (Arrestin Beta 1) • GADD45G (Growth Arrest And DNA Damage Inducible Gamma)