IT MEDI9197 was feasible for subcutaneous/cutaneous lesions but AEs precluded its use in deep-seated lesions. Although no patients responded, MEDI9197 induced systemic and intratumoral immune activation, indicating potential value in combination regimens in other patient populations.
3M-052 action was demonstrated via dendritic cell activation and production of type I IFN and other pro-inflammatory cytokines to initiate a T-cell-inflamed TME and promote tumor cell antigen presentation. This work supports neoadjuvant TLR agonist-based immunotherapeutics as realistic options for immune activation in the TME and long-term metastatic protection in TNBC.
4 years ago
Preclinical • Journal
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CD8 (cluster of differentiation 8) • IFNAR1 (Interferon (alpha, beta and omega) receptor 1)
3M-052 action was IFN-dependent, via DC activation and production of IFN and other pro-inflammatory cytokines to initiate a T cell-inflamed tissue microenvironment (TME) and promote tumor antigen presentation. Our results indicate that a single intratumoral treatment can induce TME immunoreactivity that is capable of inducing long-term protection from metastasis through formation of immunological memory and suggests that trialling IFN inducers in TNBC patients is warranted.