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    DRUG:

    YL-17231

    i
    Other names: YL-17231, TEB-17231
    Company:
    Shanghai YingLi Pharma
    Drug class:
    KRAS G12C inhibitor, KRAS G12D inhibitor, pan-KRAS inhibitor, KRAS G12V inhibitor
    Related drugs:
    6ms
    Pan-RAS Inhibitor YL-17231 in Patients With Advanced Solid Tumors Harboring Mutations in KRAS, HRAS, or NRAS (clinicaltrials.gov)
    P1, N=60, Not yet recruiting, Shanghai YingLi Pharmaceutical Co. Ltd.
    New P1 trial • Metastases
    |
    PD-L1 (Programmed death ligand 1) • KRAS (KRAS proto-oncogene GTPase) • NRAS (Neuroblastoma RAS viral oncogene homolog) • HRAS (Harvey rat sarcoma viral oncogene homolog)
    |
    KRAS mutation • NRAS mutation • HRAS mutation
    |
    YL-17231
    7ms
    A Study of YL-17231 in Patients With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=80, Recruiting, Shanghai YingLi Pharmaceutical Co. Ltd.
    New P1 trial • Metastases
    |
    PD-L1 (Programmed death ligand 1) • KRAS (KRAS proto-oncogene GTPase) • MSI (Microsatellite instability)
    |
    MSI-H/dMMR • KRAS wild-type • RAS wild-type
    |
    YL-17231