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    GENE:

    TCHH (Trichohyalin)

    i
    Other names: TCHH, Trichohyalin, THH, TRHY, THL, UHS3
    Associations

    News

    Trials
    12d
    Basal Cell Carcinoma With Matrical Differentiation Case Report and Review of Management. (PubMed, Cureus)
    Rare reports of metastasis suggest a potentially more aggressive clinical course than typical BCC. Comprehensive excision and long-term surveillance are recommended to optimize outcomes and further characterize this rare variant.
    Journal
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • TCHH (Trichohyalin)
    24d
    Oxidative Phosphorylation in Silent Pituitary Adenomas: A Multiomics Perspective. (PubMed, Int J Endocrinol)
    These findings suggest that the oxidative phosphorylation pathway plays a pivotal role in the secretory functions of pituitary adenomas. This study offers new insights into the biological mechanisms underlying pituitary adenomas and provides valuable directions for future research, emphasizing the importance of oxidative phosphorylation in tumor behavior and potential therapeutic targets.
    Journal
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    IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • MAPK1 (Mitogen-activated protein kinase 1) • MAPK3 (Mitogen-Activated Protein Kinase 3) • TCHH (Trichohyalin)
    over1year
    Next-generation integrated sequencing identifies poor prognostic factors in patients with MYD88-mutated chronic lymphocytic leukemia in Taiwan. (PubMed, Pathobiology)
    IGLL5, MYD88, and KMT2D mutations were enriched in Taiwanese CLL, and co-occurrence of MYD88 mutations with KMT2D or/and IGLL5 mutations was associated with a poorer prognosis.
    Journal
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    MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • IGH (Immunoglobulin Heavy Locus) • KMT2D (Lysine Methyltransferase 2D) • IGLL5 (Immunoglobulin Lambda Like Polypeptide 5) • DSCAM (DS Cell Adhesion Molecule) • TCHH (Trichohyalin)
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    MYD88 mutation • KMT2D mutation • MYD88 L265P • IGLL5 mutation
    over1year
    A Retrospective Study of the Clinicopathological Characteristics of Approximately 1,600 Pilomatricomas Treated at a Single Institution. (PubMed, J Nippon Med Sch)
    Pilomatricoma is more common in females, regardless of ethnicity or age, but the tumor location in the upper limbs commonly observed in Japanese patients may indicate ethnic differences. Pathologically, the fact that cells linked to follicular differentiation are observed suggests that pilomatricoma is a complex panfollicular neoplasm. Time to resection appears to correlate with Kaddu stages. Factors such as age, location, sex, depth, and stage may affect the pathological features of this tumor.
    Retrospective data • Journal
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    TCHH (Trichohyalin)
    over1year
    Targeted panel sequencing of pharmacogenes and oncodrivers in colorectal cancer patients reveals genes with prognostic significance. (PubMed, Hum Genomics)
    The present study identified several putative somatic and germline genetic events with prognostic potential for colorectal cancer that should undergo functional characterization.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • LRP1B (LDL Receptor Related Protein 1B) • FBXW7 (F-Box And WD Repeat Domain Containing 7) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • FAT4 (FAT Atypical Cadherin 4) • RYR1 (Ryanodine Receptor 1) • GLI3 (GLI Family Zinc Finger 3) • COL6A3 (Collagen Type VI Alpha 3 Chain) • NAV3 (Neuron Navigator 3 ) • RIF1 (Replication Timing Regulatory Factor 1) • TENM4 (Teneurin Transmembrane Protein 4) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • FLG (Filaggrin) • RYR3 (Ryanodine Receptor 3) • ABCA13 (ATP Binding Cassette Subfamily A Member 13) • TCHH (Trichohyalin)
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    5-fluorouracil
    almost2years
    TCHH as a Novel Prognostic Biomarker for Patients with Gastric Cancer by Bioinformatics Analysis. (PubMed, Clin Exp Gastroenterol)
    Furthermore, enrichment analysis indicated potential involvement in intermediate filament cytoskeleton organization, DNA methylation in gamete generation, cell-cell recognition, and G protein-coupled peptide receptor (GPCRs) activity. The level of TCHH mRNA may serve as a novel prognostic biomarker for gastric cancer patients.
    Journal
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    TCHH (Trichohyalin)
    over2years
    Heterogeneity of insertion/deletion and single nucleotide variation in drivers of lower grade gliomas (SNO 2023)
    Prior studies may have underestimated the frequency and heterogeneity due to calling accuracy and limitations in tumor sampling. By focusing on indels and other genetic variations within gliomas, this study sheds light on their significance in understanding tumor progression, the essential nature of CIC and ATRX inactivation over whole tumors, and the potential implications for therapeutic interventions.
    ATRX (ATRX Chromatin Remodeler) • TCHH (Trichohyalin)
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    IDH wild-type
    over2years
    Identification of MKI67, TPR and TCHH Mutations as Prognostic Biomarkers for Patients with Defective Mismatch Repair Colon Cancer Stage II/III. (PubMed, Dis Colon Rectum)
    MKI67 , TPR , and TCHH may serve as potential diagnostic and prognostic biomarkers for deficient mismatch repair/microsatellite instability-high colon cancer stage II/III.
    Retrospective data • Journal • Mismatch repair • Tumor mutational burden • MSi-H Biomarker
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    TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • TCHH (Trichohyalin)
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    MSI-H/dMMR
    over2years
    Congenital adnexal carcinoma with a cribriform pattern in a pediatric patient (ASDP 2023)
    In addition, it is important to exclude metastatic tumors from the breast, salivary gland, and gastrointestinal tract that show similar cribriform pattern histologically. Poster type: Poster Defense
    Clinical
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    KIT (KIT proto-oncogene, receptor tyrosine kinase) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • SOX10 (SRY-Box 10) • TP63 (Tumor protein 63) • TCHH (Trichohyalin)
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    KIT expression
    over2years
    Lepromatous leprosy with prominent epidermal induction: a case report (ASDP 2023)
    Further studies to interrogate this process as it relates to Hansen’s disease may yield targetable pathways relevant for diagnosis and treatment. Poster type: Poster Defense
    Clinical
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    TCHH (Trichohyalin)