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    DRUG:

    Tazverik (tazemetostat)

    i
    Other names: EZM6438, IPN60200, EPZ-6438, E7438, EZ-438, E 7438, E-7438, EPZ6438, EPZ 6438, EZ438, EZ 438, EZM-6438, EZM 6438, IPN-60200, IPN 60200
    Company:
    Eisai, Hutchmed, Ipsen, Royalty
    Drug class:
    EZH2 inhibitor
    Related drugs:
    2d
    Comprehensive Genomic Profiling of Sinonasal Carcinomas: Identification of Common Mutations and Potential Targets for Therapy. (PubMed, J Neurol Surg B Skull Base)
    Treatments include surgery, radiation, and chemotherapy, with ongoing trials investigating agents like cetuximab, cisplatin, and Tazemetostat. Tazemetostat, targeting KMT2D-related DNA (deoxyribonucleic acid) methylation, and cetuximab, targeting the PIK3CA signaling cascade, may offer therapeutic benefits. Further research on mutation-specific therapies could improve treatment strategies.
    Journal
    |
    TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • KMT2D (Lysine Methyltransferase 2D) • FAT1 (FAT atypical cadherin 1) • PRKDC (Protein Kinase, DNA-Activated, Catalytic Subunit)
    |
    TP53 mutation • PIK3CA mutation • IDH2 mutation
    |
    Erbitux (cetuximab) • cisplatin • Tazverik (tazemetostat)
    9d
    CLIN-60200-456: Study of Tazemetostat in Adults With Follicular Lymphoma Previously Treated With at Least Two Therapies (clinicaltrials.gov)
    P=N/A, N=0, Withdrawn, Ipsen | N=63 --> 0 | Not yet recruiting --> Withdrawn
    Enrollment change • Trial withdrawal • Real-world evidence
    |
    EZH2 mutation
    |
    Tazverik (tazemetostat)
    17d
    A Clinical Study of SHR-4394 in Combination With Anti-tumor Therapy in Prostate Cancer (clinicaltrials.gov)
    P1/2, N=100, Recruiting, Jiangsu HengRui Medicine Co., Ltd. | Not yet recruiting --> Recruiting
    Enrollment open
    |
    Tazverik (tazemetostat) • AiRuiEn (rezvilutamide) • HRS-5041
    19d
    SYMPHONY-1: A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma. (clinicaltrials.gov)
    P3, N=555, Active, not recruiting, Epizyme, Inc. | Recruiting --> Active, not recruiting | Trial primary completion date: Mar 2026 --> Feb 2027
    Enrollment closed • Trial primary completion date
    |
    CD4 (CD4 Molecule)
    |
    Rituxan (rituximab) • lenalidomide • Tazverik (tazemetostat)
    22d
    Study of Tazemetostat in Lymphoid Malignancies (clinicaltrials.gov)
    P1, N=6, Terminated, University of Alabama at Birmingham | N=30 --> 6 | Trial completion date: Dec 2029 --> Mar 2026 | Recruiting --> Terminated | Trial primary completion date: Jul 2028 --> Mar 2026; Ipsen, drug company requested all studies using the drug Taxemetostat be terminated due to increased risk of secondary malignancies in subjects.
    Enrollment change • Trial completion date • Trial termination • Trial primary completion date
    |
    CD4 (CD4 Molecule)
    |
    Tazverik (tazemetostat)
    23d
    A Study to Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function (clinicaltrials.gov)
    P1, N=18, Terminated, Epizyme, Inc. | Completed --> Terminated; Ipsen decided to discontinue all active tazemetostat clinical trials.
    Trial termination
    |
    Tazverik (tazemetostat)
    23d
    A Study to Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function (clinicaltrials.gov)
    P1, N=18, Completed, Epizyme, Inc. | Active, not recruiting --> Completed
    Trial completion
    |
    Tazverik (tazemetostat)
    26d
    TAZNI: Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors (clinicaltrials.gov)
    P1/2, N=49, Active, not recruiting, Susan Chi, MD | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1)
    |
    Opdivo (nivolumab) • Yervoy (ipilimumab) • Tazverik (tazemetostat)
    26d
    Study on the inhibition of thyroid undifferentiated carcinoma metastasis by nanoparticles loaded with EZH2 inhibitor. (PubMed, Transl Cancer Res)
    EZH2 is highly expressed in ATC, and its inhibitors EPZ6438 and GSK343 have anti-cancer potential. Two types of nanoparticles were successfully constructed with good sustained-release, targeting effects, and biosafety. They could improve the therapeutic efficacy and reduce toxic side effects, with GSK343-BSA@CS showing significant effects.
    Journal
    |
    EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit)
    |
    Tazverik (tazemetostat) • GSK343
    1m
    Tazemetostat in Combination With Zanubrutinib and Anti-CD20 Monoclonal Antibody in Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (clinicaltrials.gov)
    P1, N=24, Suspended, University of Utah | Recruiting --> Suspended
    Trial suspension
    |
    Rituxan (rituximab) • Gazyva (obinutuzumab) • Brukinsa (zanubrutinib) • Tazverik (tazemetostat)
    1m
    A Study to Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function (clinicaltrials.gov)
    P1, N=18, Terminated, Epizyme, Inc. | Recruiting --> Terminated; Ipsen decided to discontinue all active tazemetostat clinical trials.
    Trial termination
    |
    Tazverik (tazemetostat)
    1m
    Tazemetostat and Venetoclax in Relapsed/Refractory Non-Hodgkin Lymphoma (clinicaltrials.gov)
    P1, N=3, Terminated, Weill Medical College of Cornell University | N=38 --> 3 | Trial completion date: Dec 2028 --> Feb 2026 | Recruiting --> Terminated | Trial primary completion date: Dec 2026 --> Feb 2026; Low accrual
    Enrollment change • Trial completion date • Trial termination • Trial primary completion date
    |
    Venclexta (venetoclax) • Tazverik (tazemetostat)