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    DRUG:

    TAS-108

    i
    Other names: TAS-108, SR16234, SR-16234, SR 16234
    Associations

    News

    Trials
    Company:
    Nobelpharma, Otsuka, SRI International
    Drug class:
    Selective estrogen receptor α inhibitor
    Related drugs:
    Associations

    News

    Trials
    2ms
    SR-16234, a Unique Selective Estrogen Receptor Modulator, Suppressed Proliferation and Pain-Related Factor Expression by Inhibition of the Nuclear Factor-kappa B Pathway in Endometriotic Stromal Cells. (PubMed, Am J Reprod Immunol)
    SR appears to be a potential therapeutic agent for endometriosis by suppressing inflammatory and pain-related factor expressions by inhibiting the nuclear factor-kappa B pathway.
    Journal • Stroma
    |
    ER (Estrogen receptor) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) • NFKBIA (NFKB Inhibitor Alpha 2)
    |
    CXCL8 expression
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    TAS-108