^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    TAPBP (TAP Binding Protein)

    i
    Other names: TAPBP, TAP Binding Protein, TAPA, Tapasin, TAP Binding Protein (Tapasin), TAP-Associated Protein, NGS-17, NGS17, TPSN, TPN, TAP-Binding Protein
    3ms
    Multi-omics analysis indicates an association between TAPBP and prostate cancer. (PubMed, PLoS One)
    These 8 candidate genes (MSMB, PLG, CHMP2B, ATF6B, EGF, TAPBP, GAS1 and MMP7) were validated. After combining single-cell sequencing, Mendelian randomization, and Bayesian co-localization analyses, we identified 1 gene (TAPBP) that is strongly associated with prostate cancer.
    Journal
    |
    EGF (Epidermal growth factor) • GAS1 (Growth Arrest Specific 1) • TAPBP (TAP Binding Protein) • MMP7 (Matrix metallopeptidase 7)
    over1year
    A genetic variant in the TAPBP gene enhances cervical cancer susceptibility by increasing m6A modification. (PubMed, Arch Toxicol)
    Furthermore, the upregulation of TAPBP promoted the growth and migration of CC cells as well as tumor-forming ability, inhibited apoptosis, and conferred increased resistance to commonly used chemotherapeutic drugs such as bleomycin, cisplatin, and doxorubicin. Knockdown of TAPBP inhibited the JAK/STAT/MICB signaling pathway in CC cells and upregulated certain immune genes including ISG15, IRF3, PTPN6, and HLA-A. These findings offer insights into the involvement of genetic variations in TAPBP in the development and progression of CC.
    Journal
    |
    TAPBP (TAP Binding Protein) • METTL14 (Methyltransferase 14) • YTHDF2 (YTH N6-Methyladenosine RNA Binding Protein 2)
    |
    cisplatin • doxorubicin hydrochloride • bleomycin
    over1year
    PD-1 blockade plus COX inhibitors in dMMR metastatic colorectal cancer: Clinical, genomic, and immunologic analyses from the PCOX trial. (PubMed, Med)
    Thus, COX inhibitors combined with PD-1 blockade may be effective and safe treatment options for patients with dMMR metastatic colorectal cancer, and TAPBP may serve as a biomarker for immune checkpoint inhibitor therapy (this study was registered at ClinicalTrials.gov: NCT03638297).
    Journal • PD(L)-1 Biomarker • IO biomarker • Metastases
    |
    TAPBP (TAP Binding Protein)