^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    TAp63 overexpression

    i
    Other names: TP63, Tumor protein 63, Keratinocyte transcription factor KET, Transformation-related protein 63, Tumor protein p73-like, KET, P63, P73H, P73L, TP73L, SHFM4, EEC3, OFC8, Amplified in squamous cell carcinoma, p40, p51
    Entrez ID:
    8626
    Related biomarkers:
    Mutation
    1year
    microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin β1 recycling on the membrane. (PubMed, Apoptosis)
    Our in vivo results support the negative effect of miR-205 on metastasis. Therefore, these findings advocate the tumor suppressor activity of miR-205 in breast cancer cells and suggest that in the future development of miR-205-targeting RNAi therapeutics could be a smart alternative approach to prevent the metastatic fate of the disease.
    Journal
    |
    TP53 (Tumor protein P53) • MIR205 (MicroRNA 205)
    |
    TP53 mutation • TAp63 overexpression
    over1year
    Mutual connected IL-6, EGFR and LIN28/Let7-related mechanisms modulate PD-L1 and IGF upregulation in HNSCC using immunotherapy. (PubMed, Front Oncol)
    Furthermore, the LIN28-Let7 axis mediates the NF-κB-IL-6-STAT3 amplification loop, activated LIN28-Let7 axis up-regulates RAS, AKT, IL-6, IGF-1/2, IGF-1R, Myc, and PD-L1, plays pivotal roles in IGF-1R activation and Myc, NF-κB, STAT3 concomitant activation. Therefore, based on a detailed mechanisms review, our article firstly reveals that IL-6, EGFR, and LIN28/Let7-related mechanisms mediate PD-L1 and IGF upregulation in HNSCC, which comprehensively influences immunity, inflammation, metabolism, and metastasis in the tumor microenvironment, and might be fundamental for overcoming therapy resistance.
    Review • Journal • PD(L)-1 Biomarker • IO biomarker
    |
    EGFR (Epidermal growth factor receptor) • IL6 (Interleukin 6) • JAK1 (Janus Kinase 1) • STAT3 (Signal Transducer And Activator Of Transcription 3) • IGF1 (Insulin-like growth factor 1) • RAC1 (Rac Family Small GTPase 1) • SOX2 • IRS1 (Insulin Receptor Substrate 1) • IL6R (Interleukin 6 receptor) • TP63 (Tumor protein 63) • IGFBP3 (Insulin-like growth factor binding protein 3) • CCAT1 (Colon Cancer Associated Transcript 1)
    |
    PD-L1 expression • EGFR expression • IGF1 elevation • IGFBP3 elevation • IL6 expression • TAp63 overexpression
    over3years
    TAp63α Is Involved in Tobacco Smoke-Induced Lung Cancer EMT and the Anti-cancer Activity of Curcumin via miR-19 Transcriptional Suppression. (PubMed, Front Cell Dev Biol)
    Collectively, our results indicate that TAp63α inhibits TS-induced lung cancer EMT via transcriptionally suppressing miR-19 and the inhibitory effect of TAp63α on miR-19 mediates the anti-cancer action of curcumin. These findings provide new insights into novel targets for lung cancer prevention.
    Journal
    |
    CDH1 (Cadherin 1) • VIM (Vimentin) • TGFB1 (Transforming Growth Factor Beta 1)
    |
    CDH1 expression • VIM expression • TAp63 overexpression