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    GENE:

    TAP2 (Transporter 2, ATP Binding Cassette Subfamily B Member)

    i
    Other names: TAP2, Transporter 2, ATP Binding Cassette Subfamily B Member, RING11, PSF2, D6S217E, ABCB3, Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP), Peptide Transporter Involved In Antigen Processing 2, Really Interesting New Gene 11 Protein, Antigen Peptide Transporter 2, Peptide Transporter PSF2, Peptide Supply Factor 2, PSF-2, APT2, ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 3, Transporter 2, ABC (ATP Binding Cassette), Peptide Transporter TAP2, ABC Transporter, MHC 2, ABC18, Y1
    4ms
    Pulmonary hamartoma: a clinicopathological analysis of 316 cases (PubMed, Zhonghua Bing Li Xue Za Zhi)
    Pulmonary hamartomas overall have a good prognosis. However, those with cystic changes or intraluminal hamartomas in the bronchus may cause serious airway lesions and therefore require special attention.
    Retrospective data • Journal
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    CDK4 (Cyclin-dependent kinase 4) • JAK1 (Janus Kinase 1) • FLT1 (Fms-related tyrosine kinase 1) • SETD2 (SET Domain Containing 2, Histone Lysine Methyltransferase) • CD34 (CD34 molecule) • EP300 (E1A binding protein p300) • NKX2-1 (NK2 Homeobox 1) • MME (Membrane Metalloendopeptidase) • HMGA2 (High mobility group AT-hook 2) • TAP2 (Transporter 2, ATP Binding Cassette Subfamily B Member)
    11ms
    IL-4 mediated TAP2 downregulation is a dominant and reversible mechanism of immune evasion and immunotherapy resistance in non-small cell lung cancer. (PubMed, Mol Cancer)
    Our study reveals previously unrecognized functions of TAP2 beyond antigen presentation and establishes a reversible multi-cellular axis mediating adaptive immune evasion and immunotherapy resistance with clinical potential.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • SOCS1 (Suppressor Of Cytokine Signaling 1) • TAP2 (Transporter 2, ATP Binding Cassette Subfamily B Member) • IL4 (Interleukin 4) • TAP1 (Transporter 1)
    12ms
    Identification of TAP2 as a novel immune target in human cancers: insights from integrated bioinformatics and experimental approaches. (PubMed, Eur J Med Res)
    Our findings suggest that TAP2 may serve as a promising prognostic marker and immune target in human cancers, warranting further investigation into its role in tumor immunity.
    Journal • IO biomarker
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    TAP2 (Transporter 2, ATP Binding Cassette Subfamily B Member)
    over1year
    Determination of the Immunomodulatory Role of OTOP2 in Colon Adenocarcinoma. (PubMed, J Cancer)
    Immunohistochemical analysis of the TMAs revealed strong associations between OTOP2 expression and MHC-I, TAP1, and TAP2 expression, and between OTOP2 expression and CD8+ T cell infiltration in COAD patients. In summary, our research emphasizes the role of OTOP2 as a tumor suppressor, suggesting its use as a prognostic indicator and predictor of response to immunotherapy in COAD patients.
    Journal • IO biomarker • Immunomodulating
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    CD8 (cluster of differentiation 8) • TAP2 (Transporter 2, ATP Binding Cassette Subfamily B Member) • TAP1 (Transporter 1)
    2years
    LMP2 and TAP2 impair tumor growth and metastasis by inhibiting Wnt/β-catenin signaling pathway and EMT in cervical cancer. (PubMed, BMC Cancer)
    LMP2 and TAP2 may inhibit the oncogenesis and metastasis of cervical cancer cells by inhibiting the process of EMT and the Wnt/β-catenin signaling pathway, which may provide important insight into prospective targets for the treatment of cervical cancer.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCND1 (Cyclin D1) • TAP2 (Transporter 2, ATP Binding Cassette Subfamily B Member)
    |
    MYC overexpression