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    DRUG:

    takinib (EDHS-206)

    i
    Other names: EDHS-206
    Company:
    Duke University
    Drug class:
    TAK1 inhibitor
    Related drugs:
    5ms
    Impact of Combination Therapy with Chemical Drugs and Megavoltage X-ray Exposure on Breast Cancer Stem Cells' Viability and Proliferation of MCF-7 and MDA-MB-231 Cell Lines. (PubMed, Curr Pharm Des)
    Anti-cancer and cytotoxic effects of metformin can be effective in this strategy. In conclusion, the combination of conventional chemotherapeutic drugs, including SB203580, metformin, and takinib with X-ray exposure can be a new approach to diminish the drug resistance of breast cancer.
    Preclinical • Journal • Combination therapy • Cancer stem
    |
    CXCR4 (Chemokine (C-X-C motif) receptor 4)
    |
    CXCR4 expression
    |
    metformin • takinib (EDHS-206)
    5ms
    Neuroprotective effects of takinib on an experimental traumatic brain injury rat model via inhibition of transforming growth factor beta-activated kinase 1. (PubMed, Heliyon)
    As a result, an enhancement of neuronal function and survival was observed post-TBI. These findings highlight the medicinal value of Takinib in the management of TBI and offer an experimental justification for further investigation of TAK1 as a potential pharmacological target.
    Preclinical • Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • CASP3 (Caspase 3) • IL1B (Interleukin 1, beta) • TJP1 (Tight Junction Protein 1) • CLDN5 (Claudin 5)
    |
    takinib (EDHS-206)
    10ms
    Chronic treatment with TNF-α, alone and in combination with Takinib, SB203580 and metformin induce cell death in breast cancer. (PubMed, Heliyon)
    Although, in MCF-7 cells only combination of TNF-α and Takinib reduced BCSCs population in a time dependent manner. Altogether, we showed that TNF-α alone or in combination with other treatments can affect the progression of breast cancer.
    Journal • Combination therapy
    |
    CXCR4 (Chemokine (C-X-C motif) receptor 4) • TNFA (Tumor Necrosis Factor-Alpha) • CD44 (CD44 Molecule) • CD24 (CD24 Molecule)
    |
    CD44 expression • CXCR4 expression
    |
    metformin • takinib (EDHS-206)