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    BIOMARKER:

    TAF15-NR4A3 fusion

    i
    Other names: Nuclear receptor subfamily 4 group A member 3, Mitogen-induced nuclear orphan receptor, Neuron-derived orphan receptor, Nuclear hormone receptor NOR-1, TAF15, TATA-Box Binding Protein Associated Factor 15, RBP56, TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, N, 68kD (RNA-Binding Protein 56), TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 68kDa, TATA-Binding Protein-Associated Factor 2N, TAFII68, TAF2N, Npl3, TATA Box-Binding Protein-Associated F
    Entrez ID:
    8013; 8148
    Related biomarkers:
    Mutation
    Fusion
    3years
    [VIRTUAL] Extraskeletal Myxoid Chondrosarcoma of Bone, Osseous Myxochondroid Sarcoma/Chordoid Sarcoma of Bone, With Variant TAF15-NR4A3 Fusion: Report of an Eighth Case With 5-Year Follow-up (CAP 2021)
    Five-year follow-up includes locoregional recurrences 3 and 5 years postoperatively as well as recent lung metastases status post metastasectomy (Figure 3.14, D) and is currently NED. This case is valuable given its extremely unusual presentation in bone and its variant fusion status, and it highlights the indolent but clearly malignant behavior of this rare translocation sarcoma.
    Clinical
    |
    EWSR1 (EWS RNA Binding Protein 1) • NR4A3 (Nuclear receptor subfamily 4 group A member 3) • TAF15 (TATA-Box Binding Protein Associated Factor 15)
    |
    EWSR1-NR4A3 fusion • TAF15-NR4A3 fusion