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    GENE:

    TAF1 (TATA-Box Binding Protein Associated Factor 1)

    i
    Other names: TAF1, TATA-Box Binding Protein Associated Factor 1, TAFII250, DYT3/TAF1, NSCL2, TAF2A, KAT4, BA2R, CCG1, CCGS, TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa, Transcription Initiation Factor TFIID Subunit 1, TBP-Associated Factor 250 KDa, Cell Cycle Gene 1 Protein, TAF(II)250, TAFII-250, DYT3, P250, TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, A, 250kD, Transcription Initiation Factor TFIID 250 KDa Subunit, Complementation Of Cell Cycle Block, G1-To-S, Transcription Factor TFIID P250 Polypeptide, Dystonia 3 (With Parkinsonism), Cell Cycle, G1 Phase Defect, MRXS33, N-TAF1, XDP, OF
    Associations

    News

    Trials
    17d
    TAF1 acetyltransferase promotes colorectal carcinoma metastasis by catalyzing β-hydroxybutyrylation of KCTD9. (PubMed, Oncogene)
    Moreover, the concomitant upregulation of TAF1 and KCTD9 Kbhb serves as a poor prognostic factor for metastatic CRC patients. Taken together, our findings bridge the newly identified Kbhb modification dependent regulatory mechanism that modulates the anticancer function of KCTD9, and provided insight into potential strategies for targeting epigenetic factor and combating the KCTD9 inactive-driven CRC metastasis.
    Journal
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    TAF1 (TATA-Box Binding Protein Associated Factor 1) • TRIM21 (Tripartite Motif Containing 21)
    20d
    Myelin pathology is a key feature of X-linked Dystonia Parkinsonism. (PubMed, bioRxiv)
    Consistent with these findings, postmortem brain tissue from XDP patients revealed similar myelin pathology, including near-complete loss of myelin in parts of the medial prefrontal cortex. Together, these results identify oligodendrocyte dysfunction and myelin loss as previously unrecognized contributors to XDP pathogenesis, providing new mechanistic insight into this debilitating disorder.
    Journal
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    NES (Nestin) • TAF1 (TATA-Box Binding Protein Associated Factor 1)
    2ms
    Multi-omics analyses integration reveals a novel TRF2-miR-181a-5p-S100A10 regulatory axis in colon cancer. (PubMed, Cell Mol Biol Lett)
    Our work shows, for the first time, a broad overview on the extra-telomeric role of TRF2 in human cancer, further revealing a new axis through which TRF2 contributes to cancer progression.
    Journal
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    TAF15 (TATA-Box Binding Protein Associated Factor 15) • MIR181A1 (MicroRNA 181a-1) • TAF1 (TATA-Box Binding Protein Associated Factor 1) • TERF2 (Telomeric Repeat Binding Factor 2)
    3ms
    Thymus-like phenotype in benign lymphoepithelial neoplasms of salivary glands: clinicopathological and molecular characterization and reappraisal of relationship to non-sebaceous lymphadenoma. (PubMed, Virchows Arch)
    This is the first systematic study addressing the concept of thymus-like phenotype in benign lymphoepithelial salivary gland tumors, showing that the majority of NSLAs (65%) belong to this poorly characterized category. Frequent CYLD mutations in these histologically distinct tumors represent a novel addition to the spectrum of CYLD-mutated salivary neoplasms.
    Journal
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    KIT (KIT proto-oncogene, receptor tyrosine kinase) • DNMT3A (DNA methyltransferase 1) • BCOR (BCL6 Corepressor) • YAP1 (Yes associated protein 1) • CD5 (CD5 Molecule) • TP63 (Tumor protein 63) • MAML2 (Mastermind Like Transcriptional Coactivator 2) • TAF1 (TATA-Box Binding Protein Associated Factor 1)
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    KIT expression
    4ms
    Activation of CISD2 as a protective strategy against doxorubicin-induced cardiotoxicity. (PubMed, Redox Biol)
    Our results highlight the potential utility of Cisd2 and its activator hesperetin in chemotherapy involving doxorubicin.
    Journal
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    TAF1 (TATA-Box Binding Protein Associated Factor 1) • TCF12 (Transcription Factor 12)
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    doxorubicin hydrochloride
    6ms
    An in-silico pan-cancer bulk and single-cell profiling of transcription factors in protein autoubiquitination. (PubMed, Discov Oncol)
    However, these findings derive solely from publicly available datasets and lack experimental validation, which may introduce bias. Single-cell analyses cover only a few tumor types, drug-gene relationships remain correlative, and the absence of longitudinal clinical data prevents evaluation of true prognostic value.
    Journal • Pan tumor
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    UHRF1 (Ubiquitin Like With PHD And Ring Finger Domains 1) • RNF8 (Ring Finger Protein 8) • TAF1 (TATA-Box Binding Protein Associated Factor 1)
    6ms
    NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β-TrCP1/FBXO5 Axis. (PubMed, Adv Sci (Weinh))
    Additionally, this study uncovers a small molecule FBXO5 stabilizer that disrupts the β-TrCP1-FBXO5 interaction, thereby markedly enhancing NSP7 degradation and effectively mitigating SARS-CoV-2 infection. Taken together, the findings reveal a novel mechanism for NSP7 regulation and suggest that small-molecule activators of the E3 ubiquitin ligase FBXO5 represent a promising new class of host-directed antiviral therapies.
    Journal
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    IFIH1 (Interferon Induced With Helicase C Domain 1) • FBXO5 (F-Box Protein 5) • TAF1 (TATA-Box Binding Protein Associated Factor 1)
    7ms
    PROTAC-Mediated Degradation of TAF1 Induces Apoptosis in AML Cells and Inhibits Tumor Growth In Vivo. (PubMed, Mol Cancer Ther)
    We applied a structure-guided approach to generate cereblon recruiting Proteolysis Targeting Chimera (PROTAC) degraders of TAF1 using the chemical scaffolds of ceralasertib and GNE371...The results showed that inhibition of the bromodomain is not sufficient to inactivate TAF1 functions, whereas a PROTAC approach induces strong biological effects. Furthermore, TAF1 PROTACs have therapeutic potential against AML and other sensitive tumors.
    Preclinical • Journal
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    CRBN (Cereblon) • TAF1 (TATA-Box Binding Protein Associated Factor 1)
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    ceralasertib (AZD6738)
    7ms
    Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets. (PubMed, J Transl Med)
    This pilot study highlights the potential role of NGS analysis on solid biopsy in the assessment of the mutational profile of lung NET. A comparison of germline and somatic mutations is critical to identifying putative tumor driver mutations. In perspective, the enrichment of a subpopulation of cancer cells in the blood, with one or more specific mutations, is information of enormous clinical relevance, either for prognosis or therapeutic decisions. Translational studies on large prospective series are required to establish the role of liquid biopsy in lung NET.
    Journal
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    KDM5C (Lysine Demethylase 5C) • NOTCH4 (Notch 4) • SPTA1 (Spectrin Alpha) • SFTPA1 (Surfactant Protein A1) • TAF1 (TATA-Box Binding Protein Associated Factor 1)
    9ms
    Development and comparison of single FLT3-inhibitors to dual FLT3/TAF1-inhibitors as an anti-leukemic approach. (PubMed, PLoS One)
    However, reference compounds and in vitro cell viability and cytotoxicity assays in cancer cell lines demonstrated superior effects of high affinity tyrosine kinase inhibition compared to inhibition of the TAF1 bromodomain. Our results highlight the feasibility of dual tyrosine kinase-bromodomain targeting to overcome disease mechanisms while also revealing the increased efficacy of FLT3-targeted compounds in AML.
    Clinical • Journal
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    FLT3 (Fms-related tyrosine kinase 3) • TAF1 (TATA-Box Binding Protein Associated Factor 1)
    10ms
    Molecular Profiling of Sinonasal Adenoid Cystic Carcinoma: Canonical and Noncanonical Gene Fusions and Mutation. (PubMed, Am J Surg Pathol)
    Noncanonical fusions were predominantly observed in metatypical AdCCs. These findings emphasize the value of comprehensive molecular profiling in correlating morphologic characteristics, genetic landscape, and clinical behavior in AdCC.
    Journal
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    PTEN (Phosphatase and tensin homolog) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • RB1 (RB Transcriptional Corepressor 1) • ARID1A (AT-rich interaction domain 1A) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • NOTCH1 (Notch 1) • NF1 (Neurofibromin 1) • RUNX1 (RUNX Family Transcription Factor 1) • PALB2 (Partner and localizer of BRCA2) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • CREBBP (CREB binding protein) • BCOR (BCL6 Corepressor) • EWSR1 (EWS RNA Binding Protein 1) • KDM6A (Lysine Demethylase 6A) • EP300 (E1A binding protein p300) • DDX41 (DEAD-Box Helicase 41) • PHF6 (PHD Finger Protein 6) • PPM1D (Protein Phosphatase Mg2+/Mn2+ Dependent 1D) • NFIB (Nuclear Factor I B) • RIT1 (Ras Like Without CAAX 1) • CHD2 (Chromodomain Helicase DNA Binding Protein 2) • DNM3 (Dynamin 3) • GEN1 (GEN1 Holliday junction 5' flap endonuclease) • LZTR1 (Leucine Zipper Like Transcription Regulator 1) • MYBL1 (MYB Proto-Oncogene Like 1) • TAF1 (TATA-Box Binding Protein Associated Factor 1)
    12ms
    Harnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53. (PubMed, Adv Sci (Weinh))
    Lastly, novel upregulation of metallothionine proteins by MS172-induced p53Y220C acetylation is discovered using RNA-seq and RT-qPCR studies. This work demonstrates that TAF1 can be harnessed for AceTAC development and expands the very limited repertoire of the acetyltransferases that can be leveraged for developing AceTACs, thus advancing the targeted protein acetylation field.
    Journal
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    TP53 (Tumor protein P53) • TAF1 (TATA-Box Binding Protein Associated Factor 1)
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    TP53 wild-type • TP53 Y220C