SYP (Synaptophysin)

Since cases of early-stage gallbladder NETs are rare, their clinical behavior and long-term prognosis remain poorly understood. This case underscores the need for continued case accumulation and careful postoperative follow-up to establish appropriate management strategies for this rare entity.

Collision tumors are rare entities but thyroid collision tumors in GD are even more infrequent despite the known association between GD and differentiated thyroid cancer. The mechanisms by which this clinical entity occurs are unclear. Because it is a rare pathology, there are currently no guidelines for its treatment. Treatment must be guided separately or based on the more aggressive neoplasm.

Early detection and surgical intervention are critical for improving outcomes in gallbladder SCNEC associated with chronic inflammation.

Additional surgery confirmed no residual tumor or lymph node metastasis. Given the rarity of amphicrine carcinoma and the limited understanding of its clinical behavior, further research is necessary to determine its prognosis and optimal management strategies.

This largest integrated study defines the distinct clinicopathological and molecular profile of EBV-positive SCNEC-nasopharynx. The identified diagnostic immunophenotype and potential oncogenic pathways provide a foundation for precise diagnosis and future targeted therapy development.

P2, N=45, Active, not recruiting, University of Michigan Rogel Cancer Center | Trial completion date: Dec 2025 --> Apr 2026

When a growth is suspected, it should be thoroughly evaluated before surgery to rule out other types of invasive gallbladder tumours. If investigations confirm a non-metastatic lesion, proceeding with a simple cholecystectomy is appropriate.

Immunohistochemistry showed diffuse positivity for CD56, chromogranin A, synaptophysin, and insulinoma-associated protein 1; a Ki-67 index of about 20%; negativity for CD5, CD117 (c-KIT), p63 (TP63), CK5/6, and CD20; and the absence of TdT/CD99-positive immature T cells, supporting a diagnosis of thymic atypical carcinoid. This case highlights the complementary value of imprint cytology and an appropriate immunohistochemical panel, in addition to frozen sections, in avoiding misclassification of tNENs as type A thymoma.

Intraoperatively, tumour manipulation precipitated abrupt hypertensive surges with bradycardia, necessitating nitroglycerine and sodium nitroprusside infusion. Intraoperative haemodynamic instability during adrenal manipulation should raise suspicion of catecholamine secretion, even in the absence of classical symptoms. The report emphasises the importance of invasive monitoring and anaesthetic preparedness to manage unexpected catecholamine release.

This case underscores the need to include PGNT in the differential diagnosis of pediatric patients presenting with new-onset focal seizures and MRI findings suggestive of a low-grade glioma. Surgical management is typically curative, resulting in excellent seizure control and long-term outcomes.

Discrepancies were mainly seen in Grade 2 tumors due to tumor heterogeneity of Grade 2 lesions. To this end, future research should seek refinement of the digital algorithms and examine the reliability of prognosis and clinical endpoints based on this technique.

Integration of histomorphology with a comprehensive immunohistochemical panel supported a final diagnosis of large-cell variant MCC. This case underscores the importance of recognizing atypical morphologic and immunophenotypic presentations of MCC and reinforces the need for broad immunohistochemical evaluation to ensure appropriate management of this aggressive malignancy.