Preclinical • PARP Biomarker • Metastases
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MYC (V-myc avian myelocytomatosis viral oncogene homolog) • JAK2 (Janus kinase 2) • RUNX1 (RUNX Family Transcription Factor 1) • ASXL1 (ASXL Transcriptional Regulator 1) • CCND1 (Cyclin D1) • MCL1 (Myeloid cell leukemia 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • CDK4 (Cyclin-dependent kinase 4) • BCL2L1 (BCL2-like 1) • SRSF2 (Serine and arginine rich splicing factor 2) • CD123 (Interleukin 3 Receptor Subunit Alpha) • CD34 (CD34 molecule) • CDK6 (Cyclin-dependent kinase 6) • AURKA (Aurora kinase A) • PLK1 (Polo Like Kinase 1) • PIM1 (Pim-1 Proto-Oncogene) • ITGAM (Integrin, alpha M) • TGFB1 (Transforming Growth Factor Beta 1) • BRD4 (Bromodomain Containing 4) • CALR (Calreticulin) • CASP9 (Caspase 9) • CDK9 (Cyclin Dependent Kinase 9) • IL3RA (Interleukin 3 Receptor Subunit Alpha) • CD99 (CD99 Molecule) • CDK1 (Cyclin-dependent kinase 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • HEXIM1 (HEXIM P-TEFb Complex Subunit 1) • CLEC12A (C-Type Lectin Domain Family 12 Member A)
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TP53 mutation • JAK2 V617F
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Venclexta (venetoclax) • Jakafi (ruxolitinib) • birabresib (OTX015) • ABBV-744 • SY-5609 • pelabresib (DAK539) • mevociclib (SY-1365)