SVIL-AS1 (SVIL Antisense RNA 1)

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11ms

AKT1E17K-Interacting lncRNA SVIL-AS1 Promotes AKT1 Oncogenic Functions by Preferentially Blocking AKT1E17K Dephosphorylation. (PubMed, Adv Sci (Weinh))

Together, the findings discover a novel lncRNA regulator of mutant oncoprotein which preferentially prevents AKT1E17K dephosphorylation. Targeting SVIL-AS1 may help to improve the responses to inhibitors of the PI3K-AKT pathway, especially in AKT1E17K mutant tumors.

11 months ago

Journal

PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • PPP2R2A (Protein Phosphatase 2, Regulatory Subunit B, Alpha) • SVIL-AS1 (SVIL Antisense RNA 1)

over1year

Engineered exosomes transporting the lncRNA, SVIL-AS1, inhibit the progression of lung cancer via targeting miR-21-5p. (PubMed, Am J Cancer Res)

Furthermore, SVIL-AS1 Exos suppressed the expression of miR-21-5p and upregulated the expression of caspase-9, indicating that SVIL-AS1 may regulate the development of lung cancer through the miR-21-5p/caspase-9 pathway. In conclusion, the engineered SVIL-AS1 Exos targeted lung cancer cells to inhibit the expression of miR-21-5p, upregulate the expression of caspase-9, and inhibit the development of lung cancer.

over 1 year ago

Journal

MIR21 (MicroRNA 21) • CASP9 (Caspase 9) • SVIL-AS1 (SVIL Antisense RNA 1)

almost4years

N6-methyladenosine-induced SVIL antisense RNA 1 restrains lung adenocarcinoma cell proliferation by destabilizing E2F1. (PubMed, Bioengineered)

The reduction in cell proliferation induced by SVIL-AS1 overexpression could be rescued by E2F1 overexpression or METTL3 knockdown. In conclusion, our work demonstrated the role and mechanism of METTL3-induced SVIL-AS1 in LUAD, which connects m6A and lncRNA in lung cancer carcinogenesis.

almost 4 years ago

Journal

E2F1 (E2F transcription factor 1) • METTL3 (Methyltransferase Like 3) • SVIL-AS1 (SVIL Antisense RNA 1)