Here we report QN-030 (“Super NK cells”), an investigational, iPSC-derived NK cell product with enhanced expression of a variety of activating receptors (NKG2D and NCRs) intended for the treatment of solid tumors...Close monitoring of NKG2D/NCR expression revealed the potential mechanism of enhanced tumor killing activity. Together, we have engineered iPSC-derived QN-030 NK cells as a promising clinical drug candidate for treatment of solid tumors.
More importantly, the “super NK cells” show improved cytotoxicity to multiple solid tumors in both in vitro system and in vivo xenograft mouse models. In summary, we have engineered hiPSCs which can be differentiated into "super NK cells" as a potential cell therapy product for improved efficacy against solid tumors.