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    BIOMARKER:

    SUFU deletion

    i
    Other names: SUFU,SUFU Negative Regulator Of Hedgehog Signaling, SUFUH, Suppressor Of Fused Homolog, PRO1280, SUFUXL, Suppressor Of Fused Homolog (Drosophila), Negative Regulator Of Hedgehog Signaling, JBTS32, SUFU
    Entrez ID:
    51684
    Related biomarkers:
    Mutation
    3years
    Integrated genomics point to immune vulnerabilities in pleural mesothelioma. (PubMed, Sci Rep)
    Defects in Hippo pathways that included RASSF7 amplification and NF2 or LATS1/2 mutations were present in 50% of tumours and were accompanied by micromolar responses to the YAP1 inhibitor Verteporfin. Our results suggest new therapeutic avenues in mesothelioma and indicate targets and biomarkers for immunotherapy.
    Journal • IO biomarker
    |
    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • RB1 (RB Transcriptional Corepressor 1) • YAP1 (Yes associated protein 1) • PLK1 (Polo Like Kinase 1) • CHEK1 (Checkpoint kinase 1)
    |
    CDKN2A deletion • RB1 deletion • SUFU deletion
    |
    Visudyne (verteporfin)
    3years
    Basal cell carcinoma on the ventral site of the finger with an intronic deletion of SUFU gene. (PubMed, J Eur Acad Dermatol Venereol)
    In patients with nevoid basal cell carcinoma syndrome (NBCCS), some patients develop BCC on their palms and soles. In contrast, sporadic BCC on palms and soles is very rare in patients without genetic disposition.
    Journal
    |
    SUFU (SUFU Negative Regulator Of Hedgehog Signaling)
    |
    SUFU deletion