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    GENE:

    STXBP5L (Syntaxin Binding Protein 5L)

    i
    Other names: STXBP5L, Syntaxin Binding Protein 5L, Tomosyn-2, LLGL4, KIAA1006, Lethal(2) Giant Larvae Protein Homolog 4, Syntaxin Binding Protein 5 Like, Syntaxin-Binding Protein 5-Like, Syntaxin Binding Protein 5-Like, Tomosyn-Like
    Associations

    News

    Trials
    over2years
    Important roles of Hif1a in maternal or adult BPA exposure induced pancreatic injuries. (PubMed, Sci Rep)
    Seventeen insulin secretion-related DEGs (Stxbp5l, Fam3d, Mia3, Igf1, Hif1a, Aqp1, Kif5b, Tiam1, Map4k4, Cyp51, Pde1c, Rab3c, Arntl, Clock, Edn3, Kcnb1, and Krt20) in the BPA group were identified, and 15 regulator DEGs (Zfp830, 4931431B13Rik, Egr1, Ddit4l, Cep55, G530011O06Rik, Hspa1b, Hspa1a, Cox6a2, Ibtk, Banf1, Slc35b2, Golt1b, Lrp8, and Pttg1) with opposite expression trends and a regulator gene Cerkl with the similar expression trend in the Control and BPA groups were identified. Hif1α might be an important molecular target for pancreatic cancer caused by BPA exposure, and pregnancy is a critical window of susceptibility to BPA exposure.
    Journal
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    KIF5B (Kinesin Family Member 5B) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • IGF1 (Insulin-like growth factor 1) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • TIAM1 (TIAM Rac1 Associated GEF 1) • AQP1 (Aquaporin 1) • ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator Like) • HSPA1A (Heat Shock Protein Family A (Hsp70) Member 1A) • KRT20 (Keratin 20) • CEP55 (Centrosomal Protein 55) • EDN3 (Endothelin 3) • EGR1 (Early Growth Response 1) • STXBP5 (Syntaxin Binding Protein 5) • STXBP5L (Syntaxin Binding Protein 5L)
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    HIF1A expression