^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    STMN2 overexpression

    i
    Other names: STMN2, Stathmin 2, SCG10, SCGN10, Superior Cervical Ganglion-10 Protein, Stathmin-Like 2, Stathmin-2, Neuronal Growth-Associated Protein (Silencer Element), Superior Cervical Ganglia, Neural Specific 10, Neuron-Specific Growth-Associated Protein, Protein SCG10
    Entrez ID:
    11075
    over1year
    STMN2 overexpression promotes cell proliferation and EMT in pancreatic cancer mediated by WNT/β-catenin signaling. (PubMed, Cancer Gene Ther)
    However, XAV939 inhibited STMN2 overexpression-enhanced EMT and proliferation...STMN2 overexpression promotes the aggressive clinical stage of PC patients and promotes EMT and cell proliferation in vitro and vivo. β-catenin/TCF-mediated the transcription of STMN2.
    Journal
    |
    CCND1 (Cyclin D1) • CDH1 (Cadherin 1) • VIM (Vimentin) • STMN2 (Stathmin 2) • SNAI1 (Snail Family Transcriptional Repressor 1)
    |
    STMN2 overexpression
    |
    XAV-939
    over2years
    Acquired resistance to PRMT5 inhibition induces concomitant collateral sensitivity to paclitaxel. (PubMed, Proc Natl Acad Sci U S A)
    Finally, analysis of The Cancer Genome Atlas patient data showed that high STMN2 levels correlate with complete regression of tumors in response to taxane treatment. Collectively, this study reveals a recurring mechanism of PRMT5i resistance in LUAD and identifies collateral sensitivities that have potential clinical relevance.
    Preclinical • Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • PRMT5 (Protein Arginine Methyltransferase 5) • STMN2 (Stathmin 2)
    |
    STMN2 overexpression
    |
    paclitaxel