STMN1 (Stathmin 1)

This integrative multi-scale analysis reveals complex proliferation-associated gene expression patterns and substantial cellular heterogeneity within hepatocellular carcinoma. STMN1 and RRM2 emerge as dominant markers of proliferative reprogramming and promising candidate therapeutic targets warranting further functional investigation in HCC progression.

Our findings establish the Stmn1-lineage as a pivotal subpopulation for acinar regeneration. The ability of these cells to restore acinar tissue in an ADM-independent manner distinguishes them as a critical regenerative population. This study presents a new paradigm for acinar regeneration and repair in the context of pancreatitis and neoplasia.

Further analysis identified TFDP1 as a key gene associated with SASM and adverse prognosis, which was upregulated in tumor tissues and promoted ESCC cell proliferation in vitro. Overall, our study delineates stemness‑related tumor heterogeneity in ESCC, proposes a prognostic scoring system with immunological relevance, and highlights TFDP1 as a potential therapeutic target.

This integrated multi-omics approach reveals the complex transcriptional landscape and cellular heterogeneity in lung cancer.

Our nanoparticle offers an innovative strategy for the concurrent therapy and monitoring of ovarian cancer, enhancing therapeutic efficacy and diagnostic precision.

These markers, when integrated with cytology, could enhance the diagnostic precision and reduce dependence on invasive cystoscopy. The proposed cutoffs (10%-20% positive cells or Allred score ≤2) offer clinically actionable threshold for histopathological practice.

These collective findings establish CD5 ablation as a viable strategy to circumvent the intrinsic limitations of current T cell-based therapies, providing a mechanistic rationale for clinical translation.

The combined treatment promotes hair follicle growth by activating the Wnt/β-catenin pathway through STMN1 upregulation. BoNT/A in conjunction with PRP facilitates hair follicle growth and reconstruction through STMN1 protein modulation and Wnt/β-catenin pathway activation.

This irreparable mitotic defect triggered hyperactivation of the spindle assembly checkpoint and mitotic cell death in PTEN-deficient CRC cells. Collectively, our findings suggest that targeting STAT3-PLK1 axis represents a novel therapeutic approach for CRC cells with PTEN loss.

Through various combinations of machine learning feature selection and model construction, we ultimately built 178 diagnostic models, with the combination of glmBoost+RF having the best diagnostic performance (Average AUPR: 0.9915). The predictive web pages ( https://zclab-cnp.shinyapps.io/TC-WEB/ ) can provide convenience and reference for clinical personnel.

A 23-gene NK-TAM interaction-related signature (CINT) effectively stratified patient risk in both training and validation cohorts (P < 0.05) and predicted survival benefit in immunotherapy-treated patients. This study uncovers subtype-specific NK-TAM interactions in HNSCC and introduces CINT as a robust prognostic and immunotherapy response model, offering a new strategy for immune microenvironment-targeted therapy.

L1CAM overexpression, ER positivity, and PR status demonstrate significant prognostic relevance in NSMP endometrial cancer, warranting consideration as potential markers for improving patient management, including fertility-sparing approach.