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    GENE:

    STK25 (Serine/Threonine Kinase 25)

    i
    Other names: STK25, Serine/Threonine Kinase 25, SOK1, YSK1, Sterile 20/Oxidant Stress-Response Kinase 1, Ste20/Oxidant Stress Response Kinase 1, Serine/Threonine-Protein Kinase 25, Ste20-Like Kinase, Serine/Threonine Kinase 25 (Ste20, Yeast Homolog), Ste20, Yeast Homolog, SOK-1
    Associations

    News

    Trials
    2ms
    Identification of Novel Susceptibility Genes for Early-Onset Colorectal Cancer Through Germline Rare Variant Burden Testing. (PubMed, Cancers (Basel))
    This study identified novel candidate risk genes for EOCRC, underscoring the role of rare variants and expanding our understanding of the genetic architecture of CRC. Future studies should include functional validation and replication studies on other ancestries to confirm and extend these results.
    Journal
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    AURKB (Aurora Kinase B) • DIRAS3 (DIRAS Family GTPase 3) • ATG3 (Autophagy Related 3) • STK25 (Serine/Threonine Kinase 25)
    7ms
    STK25 Loss Augments Anti-PD-1 Therapy Efficacy by Regulating PD-L1 Stability in Colorectal Cancer. (PubMed, Adv Sci (Weinh))
    Moreover, CRC patients with low STK25 expression are more responsive to immune checkpoint blockade (ICB) therapy compared to those with high STK25 levels. Taken together, the findings reveal a critical role of STK25 for regulating PD-L1 protein stability in tumor immune evasion, and suggest that targeting STK25 may provide a potential approach to increase sensitivity to the ICB treatment in patients with CRC.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • AURKB (Aurora Kinase B) • STK25 (Serine/Threonine Kinase 25) • NEDD4 (NEDD4 E3 Ubiquitin Protein Ligase)
    12ms
    Therapeutic Potential of STE20-Type Kinase STK25 Inhibition for the Prevention and Treatment of Metabolically Induced Hepatocellular Carcinoma. (PubMed, Cell Mol Gastroenterol Hepatol)
    This study underscores STK25 antagonism as a promising therapeutic strategy for the prevention and treatment of HCC in the context of MASH.
    Journal
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    AURKB (Aurora Kinase B) • STK25 (Serine/Threonine Kinase 25)
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    sorafenib • Stivarga (regorafenib)
    1year
    ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3. (PubMed, Nat Commun)
    Importantly, depletion of MST3 reciprocally promotes accumulation of cytosolic PGAM5 by inducing mitochondrial damage. Taken together, these findings demonstrate how mtROS promotes CRC progression by activating YAP via a post-transcriptional positive feedback loop between PGAM5 and MST3, both of which can serve as potential targets for developing next-generation anti-colon cancer therapeutics.
    Journal
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    AURKB (Aurora Kinase B) • LATS1 (Large Tumor Suppressor Kinase 1) • STK25 (Serine/Threonine Kinase 25)
    2years
    New Function Annotation of PROSER2 in Pancreatic Ductal Adenocarcinoma. (PubMed, J Proteome Res)
    This is the first demonstration of the novel role of PROSER2 in antagonizing tumor progression via the STK25-AMPK pathway in PDAC. LC-MS/MS data are available at MassIVE (MSV000092953) and ProteomeXchange (PXD045646).
    Journal
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    AURKB (Aurora Kinase B) • STK25 (Serine/Threonine Kinase 25)
    2years
    Prognostic value of oxidative stress-related genes in colorectal cancer and its correlation with tumor immunity. (PubMed, BMC Genomics)
    Knockdown of CTNNB1, HSPB1, MMP3, and NOL3 significantly suppressed CRC cell proliferation, stemness and facilitated CRC cell apoptosis. In conclusion, we established prognostic CRC subtypes and an eight-gene risk model, which may provide novel prognostic indicators and benefit the design of individualized therapeutic strategies for CRC patients.
    Journal
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • AURKB (Aurora Kinase B) • HSPB1 (Heat shock 27kDa protein 1) • MMP3 (Matrix metallopeptidase 3) • STK25 (Serine/Threonine Kinase 25)
    3years
    High expression of LOC541471, GDAP1, SOD1, and STK25 is associated with poor overall survival of patients with acute myeloid leukemia. (PubMed, Cancer Med)
    High expression of LOC541471, GDAP1, SOD1, and STK25 may be biomarkers for risk stratification of AML patients, which may provide novel insight into evaluating prognosis, monitoring progression, and designing combinational targeted therapies.
    Journal
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    AURKB (Aurora Kinase B) • STK25 (Serine/Threonine Kinase 25)
    over3years
    Pan-Cancer Analysis on the Oncogenic Role of Programmed Cell Death 10. (PubMed, J Oncol)
    The results of our investigation demonstrate that PDCD10 has an oncogenic function in many cancer types. This study provides a reference for future research on antitumor therapeutic targets.
    Journal • IO biomarker • Pan tumor
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    FGFR1 (Fibroblast growth factor receptor 1) • IFNG (Interferon, gamma) • STRN (Striatin) • AURKB (Aurora Kinase B) • FGFR1OP2 (FGFR1 Oncogene Partner 2) • TGFB1 (Transforming Growth Factor Beta 1) • IKBKE (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon) • PPM1A (Protein Phosphatase Mg2+/Mn2+ Dependent 1A) • PPP2CA (Protein Phosphatase 2 Catalytic Subunit Alpha 2) • STK25 (Serine/Threonine Kinase 25)
    over3years
    Exosomal miR-4800-3p Aggravates the Progression of Hepatocellular Carcinoma via Regulating the Hippo Signaling Pathway by Targeting STK25. (PubMed, Front Oncol)
    Similar results were also obtained in vivo that knockdown of miR-4800-3p expression suppressed tumor growth induced by Huh7-derived exosomes by mediating the EMT markers and the Hippo signaling pathway. Exosomal miR-4800-3p could accelerate HCC development by regulating the Hippo signal by targeting STK25, which could be used as a new therapeutic target for HCC treatment.
    Journal
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    CDH1 (Cadherin 1) • CD44 (CD44 Molecule) • POU5F1 (POU Class 5 Homeobox 1) • AURKB (Aurora Kinase B) • TGFB1 (Transforming Growth Factor Beta 1) • CDH2 (Cadherin 2) • PCNA (Proliferating cell nuclear antigen) • TJP1 (Tight Junction Protein 1) • STK25 (Serine/Threonine Kinase 25)
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    CD44 expression • CD133 expression • PCNA expression • POU5F1 expression
    over3years
    Activation of YAP1 by STK25 contributes to the progression of hepatocellular carcinoma. (PubMed, Tissue Cell)
    HCC cells with STK25 silencing displayed a marked decrease in proliferative and invasive ability, but were highly sensitive to apoptosis induced by the chemotherapy drug sorafenib...Collectively, the results show that STK25 exerts a protumor function in HCC by enhancing YAP1 activation via regulation of MST1/2. These findings propose STK25 as a viable target for the development of anti-HCC therapy.
    Journal
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    YAP1 (Yes associated protein 1) • AURKB (Aurora Kinase B) • STK25 (Serine/Threonine Kinase 25)
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    sorafenib
    almost4years
    Downregulation of STK25 promotes autophagy via the Janus kinase 2/signal transducer and activator of transcription 3 pathway in colorectal cancer. (PubMed, Mol Carcinog)
    Moreover, the results of western blot demonstrated that silencing STK25 induced autophagy by activating the JAK2/STAT3 pathway. Therefore, STK25 could be a potential indicator for therapies targeting the JAK2/STAT3 pathway in CRC.
    Journal
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    JAK2 (Janus kinase 2) • STAT3 (Signal Transducer And Activator Of Transcription 3) • AURKB (Aurora Kinase B) • STK25 (Serine/Threonine Kinase 25)