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    GENE:

    STIP1 (Stress Induced Phosphoprotein 1)

    i
    Other names: STIP1, Stress Induced Phosphoprotein 1, STI1, Stress-Induced-Phosphoprotein 1, HOP, Transformation-Sensitive Protein IEF SSP 3521, Renal Carcinoma Antigen NY-REN-11, Hsp70/Hsp90-Organizing Protein, Hsc70/Hsp90-Organizing Protein, Epididymis Secretory Sperm Binding Protein Li 94n, NY-REN-11 Antigen, IEF-SSP-3521, HEL-S-94n, STI1L, P60, Hop
    Associations

    News

    Trials
    10ms
    Ubiquitin-proteasome Pathway-linked Gene Signatures as Prognostic Indicators in Prostate Cancer. (PubMed, Anticancer Res)
    The identified gene subset provides novel prognostic insights into PCa progression and survival. These findings highlight potential biomarkers and therapeutic targets within the ubiquitin-proteasome pathway, offering new avenues for personalized treatment strategies.
    Journal • Gene Signature • BRCA Biomarker
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    BRCA1 (Breast cancer 1, early onset) • CDH1 (Cadherin 1) • MALT1 (MALT1 Paracaspase) • SOCS1 (Suppressor Of Cytokine Signaling 1) • DDB1 (Damage Specific DNA Binding Protein 1) • CDC20 (Cell Division Cycle 20) • OASL (2'-5'-Oligoadenylate Synthetase Like) • PIAS4 (Protein Inhibitor Of Activated STAT 4) • UBE2H (Ubiquitin Conjugating Enzyme E2 H) • UHRF1 (Ubiquitin Like With PHD And Ring Finger Domains 1) • WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2) • IKBKB (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta) • UBE2C (Ubiquitin Conjugating Enzyme E2 C) • UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex) • NEDD4 (NEDD4 E3 Ubiquitin Protein Ligase) • STIP1 (Stress Induced Phosphoprotein 1)
    1year
    GOLPH3-STIP1 Complex Activates STAT3 Through Exosome Secretion to Induce Colon Cancer Metastasis. (PubMed, Biotechnol J)
    The above molecular regulatory mechanisms have also been validated in mice. In conclusion, the GOLPH3-STIP1 complex acted on surrounding CC cells through exosomes and activated the STAT3 signaling pathway to stimulate CC cell invasion and migration.
    Journal
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    STAT3 (Signal Transducer And Activator Of Transcription 3) • STIP1 (Stress Induced Phosphoprotein 1)
    almost2years
    Diagnostic value of serum STIP1 in HCC and AFP-negative HCC. (PubMed, Lab Med)
    STIP1 demonstrates excellent diagnostic value for HCC and ANHC.
    Journal
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    AFP (Alpha-fetoprotein) • STIP1 (Stress Induced Phosphoprotein 1)
    almost2years
    Stress-induced phosphoprotein 1: how does this co-chaperone influence the metastasis steps? (PubMed, Clin Exp Metastasis)
    The over-expression of STIP1 has been reported across various cancer types, identifying it as a potential biomarker for predicting patient prognosis and monitoring the progression of metastasis. Here, we present a discussion on how this co-chaperone mediates the initial steps of metastasis (cell adhesion loss, epithelial-to-mesenchymal transition, and angiogenesis), highlighting the biological mechanisms in which STIP1 plays a vital role, also presenting an overview of the current knowledge regarding its clinical relevance.
    Review • Journal
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    STIP1 (Stress Induced Phosphoprotein 1)
    over2years
    Tumor-promoting action of ubiquitin protease 43 in gastric cancer progression through deubiquitination and stabilization of stress-inducible phosphoprotein 1. (PubMed, Exp Cell Res)
    Moreover, STIP1 knockdown reversed the pro-proliferative ability of UBP43 in GC cells. Our study uncovers that the pro-proliferative role of UBP43 in GC development is STIP1-dependent and indicates that UBP43 may act as a potent therapeutic target in GC treatment.
    Journal
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    USP18 (Ubiquitin Specific Peptidase 18) • STIP1 (Stress Induced Phosphoprotein 1)