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    DRUG CLASS:

    Steroid receptor agonist

    Related drugs:
    3d
    Early Application of Budesonide Enteric-coated Capsules in the Treatment of Primary IgA Nephropathy. (clinicaltrials.gov)
    P=N/A, N=30, Recruiting, Chinese PLA General Hospital
    New trial
    5d
    Case Report: Niraparib-abiraterone in HRR-mutated metastatic castration-resistant prostate cancer: clinical insights from five cases. (PubMed, Front Oncol)
    Combination therapy with the PARP inhibitor niraparib and the androgen-receptor inhibitor abiraterone acetate plus prednisone (AAP) has recently shown improvement in radiographic progression-free survival (rPFS) in patients with metastatic castration-resistant prostate cancer (mCRPC) harboring homologous recombination repair (HRR) gene alterations, particularly BRCA1/2, in the phase III MAGNITUDE trial. However, the very small sample size, retrospective design, and absence of standardized rPFS assessment limit generalizability. These findings are primarily hypothesis-generating but align with prospective trial results and underscore the heterogeneity of HRR-mutated mCRPC, highlighting the need for individualized therapeutic strategies.
    Journal • BRCA Biomarker • PARP Biomarker
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • HRD (Homologous Recombination Deficiency) • PALB2 (Partner and localizer of BRCA2)
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    Zejula (niraparib) • abiraterone acetate • prednisone
    5d
    Intravenous Dexamethasone (0 vs 4 vs 8 mg) as an Adjunct to PENG Block for Postoperative Analgesia in Total Hip Arthroplasty: A Randomized Double-Blind Trial (clinicaltrials.gov)
    P=N/A, N=198, Not yet recruiting, Poznan University of Medical Sciences
    New trial
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    dexamethasone injection
    6d
    The Effect of Dexamethasone Administration Route in Pediatric Brachial Plexus Block (clinicaltrials.gov)
    P4, N=90, Recruiting, Poznan University of Medical Sciences | Trial completion date: Feb 2026 --> Jun 2026 | Trial primary completion date: Dec 2025 --> May 2026
    Trial completion date • Trial primary completion date
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    dexamethasone injection
    7d
    Olaparib combined with abiraterone in HRR-mutated metastatic hormone-sensitive prostate cancer: a single-arm phase II trial. (PubMed, World J Urol)
    In this phase II single-arm study, olaparib plus abiraterone and ADT showed preliminary activity and a manageable safety profile in patients with HRR-mutated mHSPC, but these findings need to be confirmed in larger phase III studies.
    P2 data • Journal • PARP Biomarker
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    HRD (Homologous Recombination Deficiency)
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    Lynparza (olaparib) • abiraterone acetate • prednisone
    7d
    Subcarinal Mass: An Unusual Presentation of Granulomatosis With Polyangiitis. (PubMed, Am J Case Rep)
    She was treated with prednisone and rituximab and had significant clinical improvement at the time of discharge. This case details an unusual presentation of GPA as a subcarinal mass. It highlights the importance of considering GPA as a possible diagnosis for patients with constitutional symptoms, mediastinal mass, and necrotizing granulomatous inflammation on pathology.
    Journal
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    PRSS3 (Serine Protease 3)
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    Rituxan (rituximab) • prednisone
    7d
    REduced-dose Steroid PrOtocol for Childhood Nephrotic SyndromE (RESPONSE) (clinicaltrials.gov)
    P3, N=50, Active, not recruiting, The Hospital for Sick Children | Recruiting --> Active, not recruiting | Trial completion date: Nov 2026 --> Feb 2027
    Enrollment closed • Trial completion date
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    prednisone • methylprednisolone sodium succinate
    7d
    The Effect of Corticosteroids on Quality of Life Following Total Hip Arthroplasty: HIPSTER Study (clinicaltrials.gov)
    P4, N=224, Recruiting, Ziekenhuis Oost-Limburg
    Trial initiation date • HEOR
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    dexamethasone injection
    11d
    TACKLE-IT Trial - Treat Acute T Cell Rejection With Evidence and Confidence in Kidney Transplant Recipients (clinicaltrials.gov)
    P3, N=540, Recruiting, University of Sydney | Not yet recruiting --> Recruiting
    Enrollment open
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    prednisone • methylprednisolone sodium succinate
    13d
    Ventilation and Perfusion in Asthmatics (clinicaltrials.gov)
    P4, N=40, Recruiting, University of Miami | Not yet recruiting --> Recruiting
    Enrollment open
    16d
    Prednisone for CRPS in Distal Radius Fracture (clinicaltrials.gov)
    P=N/A, N=40, Recruiting, University of British Columbia | Trial completion date: Jul 2026 --> Jul 2027 | Trial primary completion date: Jan 2026 --> May 2027
    Trial completion date • Trial primary completion date
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    prednisone
    16d
    Observational Study of Adult Participants With Diabetic Macular Edema and Suboptimal Response to Anti-Vascular Endothelial Growth Factor Treated With Dexamethasone Intravitreal Implant (clinicaltrials.gov)
    P=N/A, N=236, Active, not recruiting, AbbVie | Trial completion date: Jun 2026 --> Dec 2026 | Trial primary completion date: Jun 2026 --> Dec 2026
    Trial completion date • Trial primary completion date