^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    DRUG CLASS:

    Steroid receptor agonist

    Related drugs:
    5d
    OM: Ozurdex Monotherapy Trial (clinicaltrials.gov)
    P4, N=0, Withdrawn, Ottawa Hospital Research Institute | N=84 --> 0 | Trial completion date: Sep 2027 --> Jan 2025 | Recruiting --> Withdrawn | Trial primary completion date: Sep 2027 --> Jan 2025
    Enrollment change • Trial completion date • Trial withdrawal • Trial primary completion date
    |
    prednisone
    5d
    Intra-sheath vs Extra-sheath Injection for De Quervain's Tenosynovitis (clinicaltrials.gov)
    P4, N=80, Recruiting, University of California, Davis | Trial primary completion date: Dec 2024 --> Jun 2025
    Trial primary completion date
    |
    dexamethasone injection
    6d
    ALL Adult Consortium Trial: Adult ALL Trial (clinicaltrials.gov)
    P2, N=112, Active, not recruiting, Dana-Farber Cancer Institute | Trial completion date: Dec 2024 --> Mar 2025
    Trial completion date
    |
    imatinib • cytarabine • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • dexamethasone
    7d
    PRO-SCALP: A Study to Assess Treatment Satisfaction, Patient-reported Outcomes, Effectiveness, and Safety of a Fixed-dose Combination of Calcipotriene/Betamethasone Dipropionate PAD Cream in the Treatment of Mild-to-moderate Plaque Psoriasis of the Scalp in Adults (clinicaltrials.gov)
    P=N/A, N=291, Completed, Almirall, S.A. | Active, not recruiting --> Completed
    Trial completion
    7d
    REduced-dose Steroid PrOtocol for Childhood Nephrotic SyndromE (RESPONSE) (clinicaltrials.gov)
    P3, N=50, Recruiting, The Hospital for Sick Children | Not yet recruiting --> Recruiting
    Enrollment open
    |
    prednisone • methylprednisolone sodium succinate
    7d
    A Short-contact Plaque Test Study With Daivobet® Gel in Psoriasis Vulgaris (clinicaltrials.gov)
    P2, N=24, Completed, LEO Pharma | Phase classification: P2a --> P2
    Phase classification
    7d
    COSMIC: Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients (clinicaltrials.gov)
    P3, N=100, Completed, St. Joseph's Healthcare Hamilton | Recruiting --> Completed | Trial completion date: May 2025 --> Jan 2025 | Trial primary completion date: Apr 2025 --> Jan 2025
    Trial completion • Trial completion date • Trial primary completion date
    |
    dexamethasone injection
    10d
    The Impact of Type, Dose, and Duration of Prebiopsy Corticosteroids Use on Histomorphology and Immunohistochemical Stains in B-Cell Lymphoma: A Case-Control Study to Highlight the "Atypical" Cytoplasmic and Extra-Cellular Granular Staining Pattern of CD20. (PubMed, Appl Immunohistochem Mol Morphol)
    This alteration was more prevalent among patients treated with intravenous dexamethasone, high-dose corticosteroids over a short term, and with shorter dosing intervals. Prebiopsy corticosteroid administration induces changes in histomorphology and immunohistochemical staining patterns, particularly affecting CD20, thereby posing diagnostic challenges. The extent of these effects varies depending on the type, route, dosage, and duration of steroid administration.
    Journal
    |
    CD20 (Membrane Spanning 4-Domains A1)
    |
    dexamethasone injection
    11d
    COHOST: Carbon Monoxide Hyperbaric Oxygen With Steroid Therapy (clinicaltrials.gov)
    P1/2, N=20, Not yet recruiting, University of Nebraska | Initiation date: Jan 2025 --> May 2025
    Trial initiation date
    |
    dexamethasone injection
    12d
    RISE: Evaluating Immunomodulatory Interventions in Post-Acute Sequelae of SARS-CoV-2 InfEction (clinicaltrials.gov)
    P=N/A, N=632, Not yet recruiting, Huashan Hospital | N=400 --> 632 | Trial completion date: Dec 2026 --> Jul 2027 | Initiation date: Nov 2024 --> Mar 2025 | Trial primary completion date: Nov 2025 --> Jul 2027
    Enrollment change • Trial completion date • Trial initiation date • Trial primary completion date • Pan tumor
    |
    prednisone
    14d
    Comparison of Spinal Anesthesia Adjuvant and Quadratus Lumborum Block on the Opioid Requirement and Perioperative Pain of Laparoscopic Kidney Transplant Donor (clinicaltrials.gov)
    P=N/A, N=60, Recruiting, Indonesia University | Trial completion date: Jun 2026 --> Jan 2026
    Trial completion date
    |
    dexamethasone injection
    14d
    Allergic bronchopulmonary mycosis induced by pembrolizumab for bladder cancer: A case report. (PubMed, Respir Med Case Rep)
    Steroid monotherapy with prednisone was successful and pembrolizumab could be resumed. Through the present case report, we urge the clinicians to be aware of the potential risk of ABPM as a T-helper type 2-associated immune-related adverse event.
    Journal
    |
    PD-1 (Programmed cell death 1)
    |
    Keytruda (pembrolizumab) • prednisone
    18d
    Population Pharmacokinetics of Niraparib/Abiraterone Acetate Administered as Single-Agent Combination and Dual-Acting Tablets Plus Prednisone for Metastatic Castration-Resistant Prostate Cancer. (PubMed, Adv Ther)
    PPK analyses support the selected clinical dosage of RS-DAT (200-mg niraparib/1000-mg AA) plus 10-mg prednisone daily for treating patients with mCRPC and HRR gene alterations.
    PK/PD data • Journal • PARP Biomarker
    |
    HRD (Homologous Recombination Deficiency)
    |
    Zejula (niraparib) • abiraterone acetate • prednisone
    18d
    DDA-PONV: Dual-dose Aprepitant to Reduce Postoperative Nausea and Vomiting After Laparoscopic Bariatric Surgery. (clinicaltrials.gov)
    P4, N=71, Terminated, Insel Gruppe AG, University Hospital Bern | N=224 --> 71 | Recruiting --> Terminated; Low recruiting rate
    Enrollment change • Trial termination
    |
    dexamethasone injection • ondansetron
    18d
    Twice Weekly Steroids and Exercise as Therapy for DMD (clinicaltrials.gov)
    P2, N=89, Active, not recruiting, University of Florida | Recruiting --> Active, not recruiting | Trial primary completion date: Jan 2025 --> Sep 2025
    Enrollment closed • Trial primary completion date
    |
    prednisone
    19d
    Post-operative Methylprednisolone Taper Course for Orthopedic Surgery (clinicaltrials.gov)
    P4, N=500, Enrolling by invitation, Emory University | N=1000 --> 500 | Trial completion date: Jan 2025 --> Jan 2029 | Trial primary completion date: Jan 2025 --> Jan 2029
    Enrollment change • Trial completion date • Trial primary completion date
    |
    dexamethasone injection • methylprednisolone acetate • methylprednisolone oral
    19d
    Office-Based Superior Laryngeal Nerve Block for Treatment of Neurogenic Cough (clinicaltrials.gov)
    P=N/A, N=50, Recruiting, University of Alabama at Birmingham | Trial primary completion date: Oct 2024 --> Oct 2026
    Trial primary completion date
    19d
    Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients (clinicaltrials.gov)
    P2, N=180, Recruiting, Emory University | Trial primary completion date: Jan 2025 --> Jun 2026
    Trial primary completion date
    |
    dexamethasone injection • ondansetron
    19d
    Early Combined Use of Dexamethasone Intravitreal Implant and Anti-VEGF in the Treatment of DME. (clinicaltrials.gov)
    P=N/A, N=70, Active, not recruiting, Second Affiliated Hospital, School of Medicine, Zhejiang University
    New trial
    21d
    Clinical Trial to Assess Safety, Tolerability and the Pharmacodynamics Effect of Calcipotriol/Betamethasone Dipropionate in a New Administration Form in Subjects With Chronic Plaque Psoriasis. (clinicaltrials.gov)
    P1, N=15, Completed, LEO Pharma | Phase classification: P1b --> P1
    Phase classification
    22d
    A Psoriasis Plaque Test Trial With LP0113 Spray in Patients With Psoriasis Vulgaris (LP0113-1123) (clinicaltrials.gov)
    P2, N=50, Completed, LEO Pharma | Phase classification: P2a --> P2
    Phase classification
    24d
    CECUM: Endovenous Corticosteroid Pulses in Moderate Ulcerative Colitis (clinicaltrials.gov)
    P4, N=75, Terminated, Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa | Completed --> Terminated; slow recruitment rate
    Trial termination
    |
    prednisone
    25d
    TEACH: The Importance of Tailored Education And Device Handling for Asthmatic Patients (clinicaltrials.gov)
    P=N/A, N=250, Not yet recruiting, Chiesi Hungary Ltd.
    New trial
    27d
    The Effect of Low Doses of Prednisone on the Prolongation of Pregnancy in Threatened Preterm Birth (clinicaltrials.gov)
    P2/3, N=26, Completed, University of Mostar | Trial completion date: Oct 2025 --> Dec 2024 | Trial primary completion date: Oct 2025 --> Nov 2024 | Not yet recruiting --> Completed
    Trial completion • Trial completion date • Trial primary completion date
    |
    prednisone
    1m
    NefXtend: Efficacy and Safety of Extended TARPEYO® Treatment Beyond 9 Months in Adult Patients with Primary IgA Nephropathy (clinicaltrials.gov)
    P4, N=60, Recruiting, Calliditas Therapeutics AB | Not yet recruiting --> Recruiting
    Enrollment open • Real-world evidence
    1m
    IMAAGEN: Impact of Abiraterone Acetate in Prostate-Specific Antigen (clinicaltrials.gov)
    P2, N=131, Completed, Janssen Biotech, Inc. | Active, not recruiting --> Completed | Trial completion date: Jul 2025 --> Dec 2024
    Trial completion • Trial completion date
    |
    abiraterone acetate • prednisone
    1m
    Comparative Effectiveness of Particulate Versus Nonparticulate Steroid Injections for Musculoskeletal Conditions (clinicaltrials.gov)
    P4, N=165, Terminated, Stanford University | Completed --> Terminated; Slow enrollment
    Trial termination • HEOR
    |
    dexamethasone injection
    1m
    Comparison of Spinal Anesthesia Adjuvant and Quadratus Lumborum Block on the Opioid Requirement and Perioperative Pain of Laparoscopic Kidney Transplant Donor (clinicaltrials.gov)
    P=N/A, N=60, Recruiting, Indonesia University | Not yet recruiting --> Recruiting
    Enrollment open
    |
    dexamethasone injection
    1m
    Dysphagia Following Anterior Cervical Spine Surgery; Single Dose Steroid vs Saline (DysDexVSSal) (clinicaltrials.gov)
    P4, N=78, Completed, West Virginia University | Active, not recruiting --> Completed
    Trial completion
    |
    dexamethasone injection
    1m
    Corticosteroid Effect on Achalasia Variant EGJOO (clinicaltrials.gov)
    P1, N=10, Recruiting, Baylor Research Institute | Trial completion date: Dec 2024 --> Mar 2025 | Trial primary completion date: Dec 2024 --> Mar 2025
    Trial completion date • Trial primary completion date
    |
    prednisone
    1m
    Potential Modulatory Effects of Hesperidin on the JAK/STAT Pathway in Mesangial Proliferative Glomerulonephritis. (PubMed, Chem Biol Drug Des)
    A male Wistar rat model of MsPGN was established via tail vein injection of Thy-1 monoclonal antibody, and the rats were divided into four groups: Control, MsPGN, MsPGN + HSP, and MsPGN + Prednisone...Furthermore, HSP downregulated the phosphorylation levels of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), suggesting modulation of the JAK/STAT pathway. In conclusion, HSP might effectively alleviate renal injury, reduce renal inflammatory response, and inhibit renal immune complex deposition, potentially through the suppression of the JAK/STAT pathway.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • STAT3 (Signal Transducer And Activator Of Transcription 3) • IL2 (Interleukin 2) • CCL2 (Chemokine (C-C motif) ligand 2) • IL1B (Interleukin 1, beta)
    |
    prednisone
    1m
    A Case Report on an Elusive Incident of Erythema Multiforme. (PubMed, J Educ Teach Emerg Med)
    A shave biopsy was performed and intravenous acyclovir was started for concern of varicella-zoster virus. Biopsy results favored an erythema multiforme diagnosis, and she was discharged with topical clobetasol. In addition to reviewing the presentation and intervention of erythema multiforme, this case report adds to growing literature of erythema multiforme as a delayed reaction to malignancy therapy. Erythema multiforme, dermatology, radiotherapy.
    Journal
    |
    CRP (C-reactive protein)
    1m
    Case report: Gastric langerhans cell histiocytosis with BRAF deletion mutation in a child that was misdiagnosed as lymphoma. (PubMed, Front Oncol)
    The patient's condition rapidly improved after chemotherapy with prednisone and vincristine. This case report focuses on the possibility of gastric LCH in school-aged children and the differential diagnosis of gastric tumors in children.
    Journal
    |
    BRAF (B-raf proto-oncogene)
    |
    BRAF mutation
    |
    vincristine • prednisone
    2ms
    Postoperative Dexamethasone on Post-Cesarean Pain (clinicaltrials.gov)
    P4, N=21, Completed, Yale University | N=40 --> 21 | Trial completion date: Nov 2024 --> Apr 2024 | Trial primary completion date: Nov 2024 --> Apr 2024 | Recruiting --> Completed
    Trial completion • Enrollment change • Trial completion date • Trial primary completion date
    |
    dexamethasone injection
    2ms
    LASER-LICH1: Laser Vs Clobetasol for Lichen Sclerosus (clinicaltrials.gov)
    P3, N=198, Recruiting, Ruhr University of Bochum | Trial completion date: Oct 2024 --> Jul 2025 | Trial primary completion date: Jun 2024 --> Apr 2025
    Trial completion date • Trial primary completion date
    2ms
    The Effect of Needle Insertion Angle on Contrast Distribution and Treatment Outcomes in S1 Transforaminal Epidural Steroid Injections (clinicaltrials.gov)
    P=N/A, N=66, Recruiting, Marmara University
    New trial
    |
    dexamethasone injection
    2ms
    ADAPTinMCN: Active Vitamin D and Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy (clinicaltrials.gov)
    P4, N=71, Completed, University of Aarhus | Active, not recruiting --> Completed | Trial completion date: May 2025 --> Jan 2025
    Trial completion • Trial completion date • Head-to-Head
    |
    prednisone • prednisolone
    2ms
    Comparison Between the Quadratus Lumborum Block ,Erector Spinae Plane Block in Lower Abdominal Surgery (clinicaltrials.gov)
    P=N/A, N=48, Recruiting, Fayoum University Hospital | Trial primary completion date: Jan 2023 --> May 2025 | Trial completion date: Feb 2023 --> Jul 2025
    Trial completion date • Trial primary completion date
    |
    dexamethasone injection
    2ms
    FORCE2: A Study Testing the Superiority of CHF 1535 pMDI 800/24µg Total Daily Dose Compared to CHF 718 pMDI 800µg Total Daily Dose in Adults With Asthma on Medium or High-Dose Inhaled Corticosteroid (clinicaltrials.gov)
    P3, N=1377, Completed, Chiesi Farmaceutici S.p.A. | N=610 --> 1377
    Enrollment change • Head-to-Head
    2ms
    The Effect of Dexamethasone Administration Route on Pain and Inflammatory Response in PENG Block for Total Hip Arthroplasty (clinicaltrials.gov)
    P4, N=60, Not yet recruiting, Poznan University of Medical Sciences
    New P4 trial
    |
    dexamethasone injection
    2ms
    The Effect of Dexamethasone Administration Route in PENG Block for Pediatric Hip Surgery (clinicaltrials.gov)
    P4, N=60, Not yet recruiting, Poznan University of Medical Sciences
    New P4 trial
    |
    dexamethasone injection
    2ms
    The Effect of Dexamethasone Administration Route and Local Anesthetic Concentration on Pain, Inflammatory Response, and Neuromonitoring in Children Undergoing Scoliosis Correction (clinicaltrials.gov)
    P4, N=60, Not yet recruiting, Poznan University of Medical Sciences
    New P4 trial
    |
    dexamethasone injection