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    DRUG CLASS:

    Steroid receptor agonist

    Related drugs:
    18h
    MANTRA: Multimodal Anesthesia in Robotic Laparoscopic Nephrectomy (clinicaltrials.gov)
    P=N/A, N=80, Recruiting, Fundacio Puigvert | Not yet recruiting --> Recruiting
    Enrollment open
    |
    dexamethasone injection • ondansetron intravenous
    23h
    Immune checkpoint inhibitor-induced myasthenia gravis and myocarditis: a fatal immune-related adverse event. (PubMed, Immunol Res)
    Given the refractory nature of his disease course, he was subsequently treated with a repeat dose of IVIG and prednisone, then transferred to an outside facility for plasma exchange. This case highlights the rare but potentially fatal concurrent occurrence of immune-related myasthenia gravis and myocarditis as irAEs in a patient receiving durvalumab for cholangiocarcinoma. While checkpoint inhibitors have revolutionized outcomes across many solid tumor malignancies, this case underscores the diagnostic and management challenges posed by severe, refractory irAEs, and the importance of early recognition and aggressive treatment in this patient population.
    Journal • Adverse events • Checkpoint inhibition
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    PD-1 (Programmed cell death 1) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4)
    |
    Imfinzi (durvalumab) • prednisone
    1d
    Intravenous Dexamethasone (0 vs 4 vs 8 mg) as an Adjunct to PENG Block for Postoperative Analgesia in Total Hip Arthroplasty: A Randomized Double-Blind Trial (clinicaltrials.gov)
    P=N/A, N=198, Recruiting, Poznan University of Medical Sciences | Not yet recruiting --> Recruiting
    Enrollment open
    |
    dexamethasone injection
    1d
    Dexamethasone Palmitate for PONV After Minimally Invasive Endoscopic Surgery (clinicaltrials.gov)
    P=N/A, N=588, Completed, Beijing Tiantan Hospital | Recruiting --> Completed | Trial completion date: Dec 2026 --> May 2026 | Trial primary completion date: Nov 2026 --> Apr 2026
    Trial completion • Trial completion date • Trial primary completion date
    |
    dexamethasone injection
    2d
    ACB and iPACK Blocks With Intravenous Dexamethasone and Perineural Dexmedetomidine in Total Knee Arthroplasty (clinicaltrials.gov)
    P=N/A, N=120, Not yet recruiting, Poznan University of Medical Sciences
    New trial
    |
    dexamethasone injection
    5d
    Case Report: Longitudinal analysis of local immunoregulatory mediators in a DLBCL vitreoretinal lymphoma receiving local chemotherapy. (PubMed, Front Med (Lausanne))
    A patient in their 70s with unilateral VRL underwent nine serial vitreous samplings over 12 weeks of IVT therapy with methotrexate (460 μg/injection) and dexamethasone (0.4 mg/injection)...These findings propose a novel framework for integrating intraocular immunomonitoring into personalized therapeutic strategies and deepen our understanding of the complex tumor-immune microenvironment in vitreoretinal lymphoma. As derived from a single case, these observations are hypothesis-generating and require confirmation in larger cohorts.
    Journal
    |
    IFNG (Interferon, gamma) • IL6 (Interleukin 6) • HGF (Hepatocyte growth factor) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • IL10 (Interleukin 10) • CCL4 (Chemokine (C-C motif) ligand 4) • FGF2 (Fibroblast Growth Factor 2) • IL17A (Interleukin 17A) • IL1R1 (Interleukin 1 receptor, type I) • IL16 (Interleukin 16)
    |
    dexamethasone injection
    6d
    High Dose Steroid Therapy (Prednisone or Methylprednisolone) for the Improvement of Symptoms of Late Radiation-Associated Lower Cranial Neuropathy in Oropharyngeal Cancer Survivors (clinicaltrials.gov)
    P1/2, N=35, Recruiting, M.D. Anderson Cancer Center | Active, not recruiting --> Recruiting
    Enrollment open
    |
    methylprednisolone sodium succinate
    7d
    PROSPECT: Study of the Feasibility and Efficacy of PrednisonE for Non-specifiC pleuriTis (clinicaltrials.gov)
    P1, N=40, Recruiting, Icahn School of Medicine at Mount Sinai | Trial completion date: Nov 2026 --> Jun 2027 | Trial primary completion date: Nov 2026 --> Jun 2027
    Trial completion date • Trial primary completion date
    |
    prednisone
    8d
    GASPING: Giving Asthmatics Intramuscular Steroids for Preventing Return to the Emergency Department (clinicaltrials.gov)
    P4, N=182, Not yet recruiting, Montefiore Medical Center | Trial completion date: Sep 2026 --> Dec 2026 | Initiation date: Apr 2026 --> Jul 2026 | Trial primary completion date: Sep 2026 --> Dec 2026
    Trial completion date • Trial initiation date • Trial primary completion date
    |
    prednisone • dexamethasone
    9d
    Mycophenolate Mofetil w/ Prednisone for Immune Related Hepatitis From Checkpoint Inhibitor Therapy (clinicaltrials.gov)
    P2, N=31, Not yet recruiting, Fox Chase Cancer Center
    New P2 trial • Checkpoint inhibition
    |
    PD-L1 (Programmed death ligand 1) • PD-1 (Programmed cell death 1) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4)
    |
    prednisone
    9d
    HDM3015-301: A Phase III Trial To Evaluate The Efficacy And Safety Of MC2-01 Cream Compared To CAL/BDP Gel and Vehicle In Plaque Psoriasis Subjects (clinicaltrials.gov)
    P3, N=537, Active, not recruiting, Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | Recruiting --> Active, not recruiting
    Enrollment closed
    14d
    Efficacy and Safety of Anti-CD25 rhMAb in the Treatment of Steroid-Refractory cGVHD (clinicaltrials.gov)
    P4, N=30, Not yet recruiting, Peking University People's Hospital | N=118 --> 30
    Enrollment change
    |
    prednisone • cyclosporine