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    DRUG CLASS:

    Steroid receptor agonist

    Related drugs:
    23h
    Comparative Evaluation of Intraligamentary Injection of Dexamethasone, Diclofenac Sodium, and Chymotrypsin for Enhancing the Success of 4% Articaine Buccal Infiltration in Mandibular Molars With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial (clinicaltrials.gov)
    P4, N=105, Completed, Fayoum University
    New P4 trial
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    dexamethasone injection
    6d
    Glucocorticoid, Ozone and 5% Dextrose Local Injection for Pain Relief in Carpal Tunnel Syndrome (clinicaltrials.gov)
    P=N/A, N=105, Not yet recruiting, Tanta University
    New trial
    |
    dexamethasone injection
    6d
    Multi-arm Multi-modality Therapy for Very High Risk Localized and Low Volume Metastatic Prostatic Adenocarcinoma (clinicaltrials.gov)
    P2, N=102, Active, not recruiting, Memorial Sloan Kettering Cancer Center | Trial completion date: Feb 2026 --> Feb 2027 | Trial primary completion date: Feb 2026 --> Feb 2027
    Trial completion date • Trial primary completion date
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    CD4 (CD4 Molecule)
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    Oncotype DX Genomic Prostate Score® Assay
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    abiraterone acetate • prednisone • apalutamide
    6d
    Loteprednol Etabonate Versus Prednisolone Acetate for Anterior Chamber Granulomas (clinicaltrials.gov)
    P4, N=66, Completed, Fayoum University
    New P4 trial
    8d
    Study on the Safety and Efficacy of Intratympanic Injection of Small Extracellular Vesicles Derived From Mesenchymal Stem Cells in Severe and Profound Sudden Sensorineural Hearing Loss (clinicaltrials.gov)
    P1/2, N=9, Not yet recruiting, The Affiliated Hospital of Qingdao University | N=18 --> 9
    Enrollment change
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    dexamethasone injection
    9d
    Dermatomyositis with Anti-MDA5 Autoantibodies After SARS-CoV-2 mRNA Vaccination Treated with Tofacitinib: Integrating Literature Evidence and a Novel Observation. (PubMed, Antibodies (Basel))
    The review was enriched by the inclusion of a new case: a 60-year-old woman who developed anti-MDA5-positive dermatomyositis two weeks after receiving her fourth dose of the BNT162b2 (Pfizer/BioNTech) vaccine. Treatment with oral prednisone, intravenous alprostadil, and the Janus kinase inhibitor tofacitinib resulted in marked clinical improvement. This case, together with the literature review, illustrates both typical and atypical presentations of vaccine-associated anti-MDA5 DM, highlights diagnostic challenges without lung involvement, and suggests JAK inhibition as a potential therapeutic option, contributing to a more comprehensive understanding of post-vaccination dermatomyositis.
    Review • Journal
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    IFIH1 (Interferon Induced With Helicase C Domain 1)
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    prednisone • tofacitinib
    9d
    Phellinus linteus polysaccharides inhibit castration-resistant prostate cancer progression possibly via dual modulation of PIK3R1 and PGC-1α: a preclinical evaluation. (PubMed, Am J Cancer Res)
    In a castrated PC-3 xenograft model, PLP (400 mg/kg/day) suppressed tumor volume growth by 91.7% and tumor weight growth by 78.0% compared with the control group, showing efficacy comparable to abiraterone/prednisone without hepatorenal toxicity...Integrative transcriptomic and multi-omics analyses revealed coordinated downregulation of phosphatidylinositol 3-kinase-protein kinase B-mechanistic target of rapamycin signaling and upregulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). Functional validation showed that overexpression of phosphoinositide-3-kinase regulatory subunit 1 rescued PLP-induced tumor suppression, whereas knockdown of PGC-1α abolished its antioxidative and antiproliferative effects, indicating that both pathways are critically involved. These findings suggest that PLP combats CRPC by simultaneously inhibiting oncogenic signaling and mitigating oxidative stress, positioning it as a promising natural therapeutic candidate for CRPC.
    Preclinical • Journal
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    PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1)
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    abiraterone acetate • prednisone • sirolimus
    17d
    The Effect of Dexamethasone Administration Route in PENG Block for Pediatric Hip Surgery (clinicaltrials.gov)
    P4, N=60, Completed, Poznan University of Medical Sciences | Recruiting --> Completed
    Trial completion
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    dexamethasone injection
    17d
    Perineural vs Intravenous Dexamethasone as an Adjuvant to Brachial Plexus Block in Pediatric Hand Surgery (clinicaltrials.gov)
    P=N/A, N=150, Not yet recruiting, Poznan University of Medical Sciences
    New trial
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    dexamethasone injection
    20d
    Comparison of the Effects of Moderate- and High-Dose Glucocorticoids on Postoperative Recovery (clinicaltrials.gov)
    P=N/A, N=135, Not yet recruiting, Ankara City Hospital Bilkent
    New trial
    |
    dexamethasone injection
    20d
    Twice Weekly Steroids and Exercise as Therapy for DMD (clinicaltrials.gov)
    P2, N=21, Completed, University of Florida | Active, not recruiting --> Completed | N=89 --> 21
    Trial completion • Enrollment change
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    prednisone
    21d
    PREDI-PTI: Research of Predictive Factors to Immune Thrombopenic Purpura (clinicaltrials.gov)
    P=N/A, N=37, Completed, Centre Hospitalier Universitaire, Amiens | Unknown status --> Completed | N=200 --> 37
    Trial completion • Enrollment change
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    prednisone