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    DRUG:

    STC-1010

    i
    Other names: STC-1010
    Associations

    News

    Trials
    Company:
    Brenus Pharma
    Drug class:
    Immunostimulant
    Related drugs:
    Associations

    News

    Trials
    over1year
    Inovative in vivo (in ovo) CAM model to predict efficacy and mode of action of a new antitumor vaccine stc-1010 on human colorectal adenocarcinoma (AACR 2023)
    This in ovo study confirms efficacy of the STC-1010 observed in previous CRC syngeneic models and gives more insight about STC mechanism of action with the activation and maturation of dendritic cells, induction of CD8+ and LTh1 against tumor as the main driver of the response, all without toxicity. Inovotion’s CAM model could be used for indication screening and as a pre-proof-of-concept before syngeneic model study.
    Preclinical • IO biomarker
    |
    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • CD4 (CD4 Molecule)
    |
    IFNG expression
    |
    STC-1010