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    GENE:

    STAT4 (Signal Transducer And Activator Of Transcription 4)

    i
    Other names: Signal Transducer And Activator Of Transcription 4, Signal Transducer And Activator Of Transcription 4 Variant 3, SLEB11, STAT4
    Associations

    News

    Trials
    18d
    Main Genes Linked to the Immune Microenvironment in High-Grade Serous Ovarian Cancer. (PubMed, Adv Biomed Res)
    The current study recognized the most relevant genes involved in the immune system in high-grade serous ovarian cancer. The findings of this study provided a holistic understanding of the tumor microenvironment that can be used for introducing therapeutic targets.
    Journal • IO biomarker
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    IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • FANCD2 (FA Complementation Group D2) • PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22) • STAT4 (Signal Transducer And Activator Of Transcription 4) • CD3E (CD3 Epsilon Subunit Of T-Cell Receptor Complex)
    2ms
    Metabolic Reprogramming of T Cells by Dual UCP2 and IL-17 Blockade Enhances Immunity Against Pancreatic Cancer. (PubMed, Adv Sci (Weinh))
    Moreover, UCP2 inhibition enhances IFN-γ production in patient-derived PBMCs and tumor-infiltrating lymphocytes. These findings identify UCP2 as a metabolic checkpoint in cytotoxic T cells and support dual UCP2/IL-17 blockade as a promising immunotherapeutic strategy for PDAC.
    Journal
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    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • STAT4 (Signal Transducer And Activator Of Transcription 4)
    2ms
    Brahmi (Bacopa monnieri) plant preparation facilitates to enhance the activities of dendritic cells to control non-small cell lung cancer (NSCLC). (PubMed, J Cancer Res Clin Oncol)
    Overall, these findings demonstrate the ability of BPP to influence dendritic and T-cell responses in NSCLC via coordinated transcriptional and chromatinremodelling activities.
    Journal
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    TP53 (Tumor protein P53) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • STAT3 (Signal Transducer And Activator Of Transcription 3) • IL10 (Interleukin 10) • HDAC2 (Histone deacetylase 2) • TBX21 (T-Box Transcription Factor 21) • FOXP3 (Forkhead Box P3) • IL17A (Interleukin 17A) • STAT1 (Signal Transducer And Activator Of Transcription 1) • STAT6 (Signal transducer and activator of transcription 6) • IL4 (Interleukin 4) • STAT2 (Signal transducer and activator of transcription 2) • STAT5A (Signal Transducer And Activator Of Transcription 5A) • CD1D (CD1d Molecule) • CD80 (CD80 Molecule) • CD86 (CD86 Molecule) • STAT4 (Signal Transducer And Activator Of Transcription 4)
    2ms
    Integrative Multiomics and Drug Sensitivity Profiling Reveal Potential Biomarkers and Therapeutic Strategies in Pediatric Solid Tumors. (PubMed, Cancer Res)
    One signature distinguished neuroblastoma samples with sensitivity to navitoclax, a BCL2 family inhibitor...The combination of multiomics analysis and drug sensitivity profiling identified two signatures related to drug sensitivity in pediatric solid tumors, contributing to the advancement of functional precision medicine and personalized treatment strategies. This article is part of a special series: Driving Cancer Discoveries with Computational Research, Data Science, and Machine Learning/AI .
    Journal • IO biomarker
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    MGAM (Maltase-Glucoamylase) • SIX1 (SIX Homeobox 1) • STAT4 (Signal Transducer And Activator Of Transcription 4)
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    navitoclax (ABT 263)
    2ms
    Disruption of epidermal growth factor receptor signaling and cytoskeletal dynamics by mebendazole and gefitinib synergistically impairs paracrine cytokine signaling in non-small cell lung cancer and triple-negative breast cancer Cell lines. (PubMed, PLoS One)
    The combination of mebendazole and gefitinib effectively suppresses tumor cell viability and modulates key pathways involved in cancer progression. By targeting cytoskeletal integrity and EGFR signaling, it may disrupt cytokine and tumor-microenvironment interactions, supporting further exploration as a strategy to overcome resistance in lung and breast cancers.
    Preclinical • Journal
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    EGFR (Epidermal growth factor receptor) • IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • MMP2 (Matrix metallopeptidase 2) • IL1B (Interleukin 1, beta) • STAT4 (Signal Transducer And Activator Of Transcription 4)
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    gefitinib • mebendazole
    3ms
    Impact of immunotherapy on outcomes of cutaneous melanoma and concurrent brain metastasis: a surveillance, epidemiology, and end results analysis of 2010-2020. (PubMed, J Clin Neurosci)
    The introduction of immunotherapy with checkpoint inhibitors significantly improved OS among patients with MBM and may have helped mitigate historical disparities in survival between men and women.
    Journal
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    STAT4 (Signal Transducer And Activator Of Transcription 4)
    3ms
    Molecular Basis of Simalikalactone D Sensitivity in Triple-Negative Breast Cancer Cells. (PubMed, Biomolecules)
    In silico docking confirmed favorable binding affinities of SKD to both EGFR (ΔG = -6.718 kcal/mol) and STAT4 (ΔG = -8.481 kcal/mol). Overall, our findings suggest that SKD is a potent anticancer agent in a subgroup of TNBC cells.
    Journal • PARP Biomarker • IO biomarker
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    EGFR (Epidermal growth factor receptor) • BCL2 (B-cell CLL/lymphoma 2) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • BIRC5 (Baculoviral IAP repeat containing 5) • CASP3 (Caspase 3) • DAXX (Death-domain associated protein) • ITGB1 (Integrin Subunit Beta 1) • STAT4 (Signal Transducer And Activator Of Transcription 4)
    3ms
    A Unique Chimeric RNA: ERCC1-iASPP Drives Benzo[a]pyrene-Induced Lung Carcinogenesis via Dual Coding and Non-Coding Mechanisms. (PubMed, Adv Sci (Weinh))
    Collectively, these findings establish ERCC1-iASPP as a bifunctional RNA with both protein-coding and non-coding regulatory roles that cooperatively promote B[a]P-induced lung tumorigenesis. This study highlights ERCC1-iASPP as a potential diagnostic and therapeutic target in smoking-related lung cancer.
    Journal
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    ERCC1 (Excision repair cross-complementation group 1) • CDK1 (Cyclin-dependent kinase 1) • MIR143 (MicroRNA 143) • PGK1 (Phosphoglycerate Kinase 1) • STAT4 (Signal Transducer And Activator Of Transcription 4)
    3ms
    Quinovic Acid Enhances the Cytotoxicity of KHYG-1 Cells by Modulating the Ras/MAPK Signalling Pathway and Interferon-Gamma Expression. (PubMed, J Cell Mol Med)
    These effects were observed not only in KHYG-1 cells but also in NK cells derived from adult patients with head and neck squamous cell carcinoma. Our findings suggest that quinovic acid enhances NK cell cytotoxicity, showing promise as a potential therapeutic against various cancer cell types.
    Journal • PARP Biomarker
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    IFNG (Interferon, gamma) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • FASLG (Fas ligand) • CASP8 (Caspase 8) • CASP9 (Caspase 9) • HMGB2 (High Mobility Group Box 2) • NKG2D (killer cell lectin like receptor K1) • STAT4 (Signal Transducer And Activator Of Transcription 4)
    3ms
    Inhibition of RBPJ transcription complex promotes IL-17 and IFN-γ secretion by CD4⁺ T cells in hepatocellular carcinoma. (PubMed, Arch Pharm Res)
    In vivo, RIN1 promoted the expression of IL-17 and IFN-γ in CD4+ TILs while suppressing PD-1 expression and reducing the frequency of Treg cells, exhibiting tumor growth inhibition. These findings suggested that RIN1 enhances CD4+ T cell-mediated antitumor immunity in HCC by modulating gene transcription and cell subset differentiation, highlighting its potential as an immunostimulatory agent (Graphical abstract).
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • IFNG (Interferon, gamma) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CD4 (CD4 Molecule) • TBX21 (T-Box Transcription Factor 21) • IL17A (Interleukin 17A) • CXCR3 (C-X-C Motif Chemokine Receptor 3) • NICD (NOTCH1 intracellular domain) • KLRB1 (Killer Cell Lectin Like Receptor B1) • STAT4 (Signal Transducer And Activator Of Transcription 4)
    3ms
    Development of a PANoptosis-Related Pathomics Prognostic Model in Ovarian Cancer: A Multi-Omics Study. (PubMed, J Cell Mol Med)
    The PANPM, manifesting distinct advantages for clinical application by accurately extracting pathological features, performed excellently in validation and the high-risk group indicated a poor prognosis. Additionally, STAT4+ T cells may inhibit OC, by activating the PANoptosis of epithelial cells through TNFSF12-TNFRSF12A and TNF-TNFRSF1A, which sheds light on potential therapeutic interventions involving STAT4+ T cells.
    Journal
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    TNFRSF1A (TNF Receptor Superfamily Member 1A) • STAT4 (Signal Transducer And Activator Of Transcription 4) • TNFRSF12A (TNF Receptor Superfamily Member 12A)