STAT3 (Signal Transducer And Activator Of Transcription 3)

The in silico and in vitro studies suggest that curcumin can act as a drug prototype targeting protein-protein interaction interfaces. This review broadens the understanding of curcumin pharmacological action and provides a foundation for future experimental studies on its protein targets verification.

Thirty-eight pharmaceuticals demonstrated significant associations with cheilitis, with isotretinoin being the most frequently reported (ROR = 42.61) and crisaborole exhibiting the most pronounced signal (ROR = 550.48)...Molecular docking studies indicated strong binding affinities (ranging from -8.1 to -6.2 kcal/mol), particularly for the afatinib-EGFR and capecitabine-IL-6 interactions...ADMET profiling predicted a high risk of drug-induced liver injury for four compounds, while lamotrigine demonstrated a favorable safety profile. This integrative framework connects population-level indicators with mechanistic forecasts, providing a translational model for comprehending, predicting, and managing drug-induced cheilitis.

Thiazolidinedione agonists (pioglitazone, rosiglitazone) have modest but clinically significant anti-psoriatic efficacy when combined with traditional systemic medicines, resulting in cardiometabolic benefits. Future directions include patient biomarker stratification, dual/selective agonists (glitazars), and sensible combination with biologics that target tumor necrosis factor-alpha/IL-17/IL-23. This review reframes PPARs as key players in the relationship between psoriasis and metabolic syndrome by synthesizing molecular understanding and clinical data.

Genetic and transcriptomic evidence jointly support the concept of a myeloid-inflammation axis in PCOS. The inverse MR association for absolute monocyte count alongside positive risk for CD33+HLA-DR+ compartments, together with cross-cohort evidence of myeloid enrichment and inflammatory pathway activation, is compatible with a potential mechanistic link between immune imbalance and PCOS and provides a hypothesis-generating framework for future therapeutic investigation.

This preliminary study demonstrates its potential anticancer, antibacterial, antioxidant, and anti-inflammatory activities in vitro. However, further detailed investigations, including more extensive in vitro studies as well as in vivo evaluations, are required to better elucidate its mechanisms, safety, and potential biological applications.

These co-regulated proteins highlight the integration of BRAF signaling with critical processes, such as cell cycle control, apoptosis, DNA damage response, and protein synthesis in melanoma. Our analysis suggests that targeting BRAF-interacting proteins may also modulate oncogenic signaling pathways and represent promising biomarkers for melanoma diagnosis and therapy.

MiR-124-3p functions as a tumor suppressor in glioma by repressing STAT3/NAMPT-mediated AKT/ERK signaling, highlighting its potential as a diagnostic biomarker and therapeutic target for glioma management.

In conclusion, SERPINE1 inhibition restricts macrophage infiltration and shifts macrophage polarization away from M2-like phenotypes, enabling stronger tumor control when combined with anti-PD-1 therapy. These findings suggest the potential of targeting SERPINE1 as a strategy to enhance the efficacy of immunotherapy in NSCLC.

Thus, senescence represents a biological paradox: a protective, transient process that maintains tissue integrity but, when unresolved, transforms into a driver of aging and malignancy. Understanding the molecular determinants, distinguishing beneficial from pathological senescence is crucial for developing targeted senotherapies.

Wnt-related gene sets were also enriched in the mesenchymal-like immune-altered (MLIA) subtype of 699 primary TNBC tumors. These findings highlight the role of basal Wnt activity in driving pro-tumorigenic transcriptional programs in TNBC and provide new insight into its contribution to subtype-specific disease features.

Our findings demonstrate that both nature and positional orientation of a chemotherapeutic tail on G-quadruplex aptamers can be strategically employed to modulate both structural conformation and biological function. This work establishes a rational design strategy for engineering aptamer-drug conjugates with tunable structural and cytotoxic properties.

Moreover, artesunate promotes ferroptosis by inhibiting the STAT3/SLC25A27/ SLC7A11/GPX4 axis in vivo and in vitro. Overall, our study confirmed the combination of artesunate and lenvatinib significantly enhances the anti-HCC effect of lenvatinib, which promising therapeutic strategy to circumvent resistance in HCC.