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    GENE:

    STAT2 (Signal transducer and activator of transcription 2)

    i
    Other names: STAT2, Signal transducer and activator of transcription 2, P113, Interferon alpha induced transcriptional activator
    7d
    Serum type I interferon promotes AIM2 inflammasome dysregulation in lupus patients through STAT1 and STAT2. (PubMed, Rheumatology (Oxford))
    A novel pathway by which serum type-I IFN propagates innate immune dysfunction in SLE via the STAT1-STAT2/AIM2 inflammasome axis in monocytes has been revealed.
    Journal
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    IL18 (Interleukin 18) • AIM2 (Absent In Melanoma 2) • STAT1 (Signal Transducer And Activator Of Transcription 1) • IL1B (Interleukin 1, beta) • STAT2 (Signal transducer and activator of transcription 2)
    17d
    miR-194-5p targets SOCS2 to predict pegIFNα treatment response in HBeAg-positive chronic hepatitis B patients. (PubMed, Virol J)
    miR-194-5p may predict pegIFNα response in HBeAg-positive CHB. It regulates interferon signaling by targeting SOCS2 and modulating the JAK-STAT pathway activation, suggesting the miR-194-5p/SOCS2 axis as a potential therapeutic target.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IFNA1 (Interferon Alpha 1) • IL1B (Interleukin 1, beta) • SOCS2 (Suppressor Of Cytokine Signaling 2) • STAT2 (Signal transducer and activator of transcription 2) • MIR194 (MicroRNA 194)
    18d
    STAT2 Mediated Epigenetic and Epitranscriptomic Regulation of CD4+ T Helper Cell Differentiation in Non-Small Cell Lung Cancer (NSCLC). (PubMed, Immunology)
    These findings identify STAT2 as a crucial regulator of immune function in the lung cancer microenvironment. Targeted STAT2 inhibition in tumour-reactive T cells may reinstate anti-tumour immunity, although systemic inhibition requires further research on targeted intervention strategies.
    Journal
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    CD4 (CD4 Molecule) • STAT2 (Signal transducer and activator of transcription 2)
    1m
    The potential of antimicrobial peptides to treat oral infections and cancer. (PubMed, Front Med (Lausanne))
    Peptides such as Nal-P113, hCAP(109-135), and Nisin Z exhibit both antimicrobial and antitumor activity, making them promising therapeutic agents for the prevention and treatment of oral infections and cancer. However, owing to the limitations of AMPs, further in vitro and in vivo safety and efficacy studies are needed before their commercialization.
    Review • Journal
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    STAT2 (Signal transducer and activator of transcription 2)
    2ms
    Phase II trial of interleukin-12 followed by interferon alfa-2b in patients with metastatic malignant melanoma: Results from CALGB 500001 (Alliance). (PubMed, Cancer Immunol Res)
    Combination therapy was reasonably well-tolerated but conferred marginal benefit in patients with metastatic melanoma. These results can inform future studies that employ recombinant IL-12 or novel IL-12 constructs.
    P2 data • Journal
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    IFNG (Interferon, gamma) • STAT1 (Signal Transducer And Activator Of Transcription 1) • IFNA1 (Interferon Alpha 1) • STAT2 (Signal transducer and activator of transcription 2)
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    Intron A (interferon α-2b)
    2ms
    Mutational Spectrum of T-Cell Large Granular Lymphocytic Leukemia: Insights From the AACR Project GENIE Consortium. (PubMed, Cancer Genomics Proteomics)
    This study provides a comprehensive genomic profile of T-LGLL, identifying recurrent somatic mutations and commonly affected pathways. Notably, frequent alterations were observed in the FAS-FASL signaling pathway, underscoring its potential as a target for therapeutic development.
    Retrospective data • Journal
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    EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • DNMT3A (DNA methyltransferase 1) • KMT2D (Lysine Methyltransferase 2D) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • STAT3 (Signal Transducer And Activator Of Transcription 3) • FASLG (Fas ligand) • IKZF3 (IKAROS Family Zinc Finger 3) • TNFAIP3 (TNF Alpha Induced Protein 3) • EPHB1 (EPH Receptor B1) • SETD1B (SET Domain Containing 1B, Histone Lysine Methyltransferase) • STAT2 (Signal transducer and activator of transcription 2) • ALOX12B (Arachidonate 12-Lipoxygenase) • DDX3X (DEAD-Box Helicase 3 X-Linked)
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    TP53 mutation • STAT3 mutation
    2ms
    STAT2 Promotes Tumor Growth in Colorectal Cancer Independent of Type I IFN Receptor Signaling. (PubMed, Curr Oncol)
    However, in xenograft tumor transplantation models, IFNAR1 KO cells formed larger tumors while STAT2 KO tumor cells formed smaller ones compared to parental tumor cells. These findings indicate that STAT2 promotes colorectal cancer growth through mechanisms independent of IFNAR1 signaling.
    Journal
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    IFNAR1 (Interferon (alpha, beta and omega) receptor 1) • STAT2 (Signal transducer and activator of transcription 2)
    2ms
    Brahmi (Bacopa monnieri) plant preparation facilitates to enhance the activities of dendritic cells to control non-small cell lung cancer (NSCLC). (PubMed, J Cancer Res Clin Oncol)
    Overall, these findings demonstrate the ability of BPP to influence dendritic and T-cell responses in NSCLC via coordinated transcriptional and chromatinremodelling activities.
    Journal
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    TP53 (Tumor protein P53) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • STAT3 (Signal Transducer And Activator Of Transcription 3) • IL10 (Interleukin 10) • HDAC2 (Histone deacetylase 2) • TBX21 (T-Box Transcription Factor 21) • FOXP3 (Forkhead Box P3) • IL17A (Interleukin 17A) • STAT1 (Signal Transducer And Activator Of Transcription 1) • STAT6 (Signal transducer and activator of transcription 6) • IL4 (Interleukin 4) • STAT2 (Signal transducer and activator of transcription 2) • STAT5A (Signal Transducer And Activator Of Transcription 5A) • CD1D (CD1d Molecule) • CD80 (CD80 Molecule) • CD86 (CD86 Molecule) • STAT4 (Signal Transducer And Activator Of Transcription 4)
    3ms
    LC3-dependent intercellular transfer of phosphorylated STAT1/2 elicits CXCL9+ macrophages and enhances radiation-induced antitumor immunity. (PubMed, J Clin Invest)
    This process promotes the expression of T cell chemokines and upregulates the antigen presentation machinery, thereby enhancing radiation-induced CD8+ T cell antitumor immunity and radiotherapy efficacy. Our findings reveal a critical role of USP5 in type I IFN-induced antitumor immunity, providing potential targets for improving the efficacy of radiotherapy.
    Journal
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    CD8 (cluster of differentiation 8) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • STAT1 (Signal Transducer And Activator Of Transcription 1) • STAT2 (Signal transducer and activator of transcription 2) • USP5 (Ubiquitin Specific Peptidase 5)
    5ms
    Plumbagin remodels the tumor immune microenvironment to overcome cisplatin resistance in tongue squamous cell carcinoma via KLF2 activation and ZWINT/NF-κB inhibition. (PubMed, Int Immunopharmacol)
    These dual actions-tumor chemosensitization via ZWINT/NF-κB inhibition and immune reprogramming via KLF2 activation-were functionally interconnected, as cytokines released by PLB-primed T cells reinforced NF-κB suppression in tumor cells. Collectively, our findings identify PLB as a low-cost small molecule that integrates cisplatin sensitization with immune activation, offering a promising adjunctive strategy for cisplatin-refractory TSCC.
    Journal
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    CD8 (cluster of differentiation 8) • JAK1 (Janus Kinase 1) • STAT2 (Signal transducer and activator of transcription 2) • ZWINT (ZW10 Interacting Kinetochore Protein)
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    cisplatin
    5ms
    OCIAD2 as a novel prognostic and therapeutic biomarker for pancreatic cancer: A study based on transcriptomic signature and bioinformatics analysis. (PubMed, PLoS Comput Biol)
    These results indicate that OCIAD2 is a potential prognostic biomarker and therapeutic target for PC patients.
    Journal
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    CCND1 (Cyclin D1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • CDK1 (Cyclin-dependent kinase 1) • CTSK (Cathepsin K) • STAT2 (Signal transducer and activator of transcription 2) • ACSL5 (Acyl-CoA Synthetase Long Chain Family Member 5) • ANTXR1 (ANTXR Cell Adhesion Molecule 1)
    5ms
    A novel GM-CSF-encoding oncolytic adenovirus induces profound autophagy and promotes viral replication to enhance anti-tumor efficacy. (PubMed, Cancer Gene Ther)
    The use of autophagy and JAK-2 inhibitors, Chloroquine (CQ) and AG-490, respectively, significantly mitigated the apoptosis induced by oAd-CMV-GM-CSF...In vivo oAd-CMV-GM-CSF had stronger anti-tumor effect than oAd-GM-CSF in immunodeficient model and immune-competent model. Our findings indicate that oAd-CMV-GM-CSF induces more profound autophagy and promoting viral replication to enhance the anti-tumor efficacy.
    Journal
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    CSF2 (Colony stimulating factor 2) • STAT2 (Signal transducer and activator of transcription 2)
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    chloroquine phosphate