^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    STAT2 (Signal transducer and activator of transcription 2)

    i
    Other names: STAT2, Signal transducer and activator of transcription 2, P113, Interferon alpha induced transcriptional activator
    5d
    Linking Targeted Pancreatic Cancer Genes With Metabolic Disorders: A Cross-Species Translational Pathway. (PubMed, Cancer Med)
    Our findings highlight a strong association between the upregulation of PDAC recurrence genes and the activation of metabolic pathways linked to obesity, diabetes, and inflammation. The consistent expression patterns across species suggest potential for developing targeted therapies to inhibit these metabolic pathways post-pancreatic cancer resection, potentially reducing fatality.
    Journal
    |
    CXCL10 (Chemokine (C-X-C motif) ligand 10) • ITGAM (Integrin, alpha M) • CD31 (Platelet and endothelial cell adhesion molecule 1) • STAT1 (Signal Transducer And Activator Of Transcription 1) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • STAT2 (Signal transducer and activator of transcription 2)
    10d
    Conditional Stat2 Knockout Mice as a Platform for Modeling Human Diseases. (PubMed, Immuno)
    Tissue-specific Cre models demonstrated selective ablation of STAT2 in target compartments without affecting its expression in non-target tissues. Together, these studies expand our published conditional Stat2 KO findings and highlight the value of this model as a versatile platform for dissecting STAT2-dependent signaling pathways in a tissue- and disease-specific manner.
    Preclinical • Journal
    |
    CDX2 (Caudal Type Homeobox 2) • ITGAX (Integrin Subunit Alpha X) • STAT2 (Signal transducer and activator of transcription 2) • IFNB1 (Interferon Beta 1)
    1m
    Apolipoprotein D downregulation in OSCC: multi-database validation and clinical significance. (PubMed, BMC Med Genomics)
    APOD expression is significantly reduced in OSCC, demonstrating potential as a diagnostic and prognostic biomarker. Its downregulation may facilitate disease progression through disruption of the Type I interferon-mediated JAK-STAT signaling pathway.
    Journal
    |
    JAK1 (Janus Kinase 1) • TYK2 (Tyrosine Kinase 2) • STAT2 (Signal transducer and activator of transcription 2)
    2ms
    Serum type I interferon promotes AIM2 inflammasome dysregulation in lupus patients through STAT1 and STAT2. (PubMed, Rheumatology (Oxford))
    A novel pathway by which serum type-I IFN propagates innate immune dysfunction in SLE via the STAT1-STAT2/AIM2 inflammasome axis in monocytes has been revealed.
    Journal
    |
    IL18 (Interleukin 18) • AIM2 (Absent In Melanoma 2) • STAT1 (Signal Transducer And Activator Of Transcription 1) • IL1B (Interleukin 1, beta) • STAT2 (Signal transducer and activator of transcription 2)
    2ms
    miR-194-5p targets SOCS2 to predict pegIFNα treatment response in HBeAg-positive chronic hepatitis B patients. (PubMed, Virol J)
    miR-194-5p may predict pegIFNα response in HBeAg-positive CHB. It regulates interferon signaling by targeting SOCS2 and modulating the JAK-STAT pathway activation, suggesting the miR-194-5p/SOCS2 axis as a potential therapeutic target.
    Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IFNA1 (Interferon Alpha 1) • IL1B (Interleukin 1, beta) • SOCS2 (Suppressor Of Cytokine Signaling 2) • STAT2 (Signal transducer and activator of transcription 2) • MIR194 (MicroRNA 194)
    2ms
    STAT2 Mediated Epigenetic and Epitranscriptomic Regulation of CD4+ T Helper Cell Differentiation in Non-Small Cell Lung Cancer (NSCLC). (PubMed, Immunology)
    These findings identify STAT2 as a crucial regulator of immune function in the lung cancer microenvironment. Targeted STAT2 inhibition in tumour-reactive T cells may reinstate anti-tumour immunity, although systemic inhibition requires further research on targeted intervention strategies.
    Journal
    |
    CD4 (CD4 Molecule) • STAT2 (Signal transducer and activator of transcription 2)
    3ms
    The potential of antimicrobial peptides to treat oral infections and cancer. (PubMed, Front Med (Lausanne))
    Peptides such as Nal-P113, hCAP(109-135), and Nisin Z exhibit both antimicrobial and antitumor activity, making them promising therapeutic agents for the prevention and treatment of oral infections and cancer. However, owing to the limitations of AMPs, further in vitro and in vivo safety and efficacy studies are needed before their commercialization.
    Review • Journal
    |
    STAT2 (Signal transducer and activator of transcription 2)
    3ms
    Phase II trial of interleukin-12 followed by interferon alfa-2b in patients with metastatic malignant melanoma: Results from CALGB 500001 (Alliance). (PubMed, Cancer Immunol Res)
    Combination therapy was reasonably well-tolerated but conferred marginal benefit in patients with metastatic melanoma. These results can inform future studies that employ recombinant IL-12 or novel IL-12 constructs.
    P2 data • Journal
    |
    IFNG (Interferon, gamma) • STAT1 (Signal Transducer And Activator Of Transcription 1) • IFNA1 (Interferon Alpha 1) • STAT2 (Signal transducer and activator of transcription 2)
    |
    Intron A (interferon α-2b)
    3ms
    Mutational Spectrum of T-Cell Large Granular Lymphocytic Leukemia: Insights From the AACR Project GENIE Consortium. (PubMed, Cancer Genomics Proteomics)
    This study provides a comprehensive genomic profile of T-LGLL, identifying recurrent somatic mutations and commonly affected pathways. Notably, frequent alterations were observed in the FAS-FASL signaling pathway, underscoring its potential as a target for therapeutic development.
    Retrospective data • Journal
    |
    EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • DNMT3A (DNA methyltransferase 1) • KMT2D (Lysine Methyltransferase 2D) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • STAT3 (Signal Transducer And Activator Of Transcription 3) • FASLG (Fas ligand) • IKZF3 (IKAROS Family Zinc Finger 3) • TNFAIP3 (TNF Alpha Induced Protein 3) • EPHB1 (EPH Receptor B1) • SETD1B (SET Domain Containing 1B, Histone Lysine Methyltransferase) • STAT2 (Signal transducer and activator of transcription 2) • ALOX12B (Arachidonate 12-Lipoxygenase) • DDX3X (DEAD-Box Helicase 3 X-Linked)
    |
    TP53 mutation • STAT3 mutation
    4ms
    STAT2 Promotes Tumor Growth in Colorectal Cancer Independent of Type I IFN Receptor Signaling. (PubMed, Curr Oncol)
    However, in xenograft tumor transplantation models, IFNAR1 KO cells formed larger tumors while STAT2 KO tumor cells formed smaller ones compared to parental tumor cells. These findings indicate that STAT2 promotes colorectal cancer growth through mechanisms independent of IFNAR1 signaling.
    Journal
    |
    IFNAR1 (Interferon (alpha, beta and omega) receptor 1) • STAT2 (Signal transducer and activator of transcription 2)
    4ms
    Brahmi (Bacopa monnieri) plant preparation facilitates to enhance the activities of dendritic cells to control non-small cell lung cancer (NSCLC). (PubMed, J Cancer Res Clin Oncol)
    Overall, these findings demonstrate the ability of BPP to influence dendritic and T-cell responses in NSCLC via coordinated transcriptional and chromatinremodelling activities.
    Journal
    |
    TP53 (Tumor protein P53) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • STAT3 (Signal Transducer And Activator Of Transcription 3) • IL10 (Interleukin 10) • HDAC2 (Histone deacetylase 2) • TBX21 (T-Box Transcription Factor 21) • FOXP3 (Forkhead Box P3) • IL17A (Interleukin 17A) • STAT1 (Signal Transducer And Activator Of Transcription 1) • STAT6 (Signal transducer and activator of transcription 6) • IL4 (Interleukin 4) • STAT2 (Signal transducer and activator of transcription 2) • STAT5A (Signal Transducer And Activator Of Transcription 5A) • CD1D (CD1d Molecule) • CD80 (CD80 Molecule) • CD86 (CD86 Molecule) • STAT4 (Signal Transducer And Activator Of Transcription 4)
    4ms
    LC3-dependent intercellular transfer of phosphorylated STAT1/2 elicits CXCL9+ macrophages and enhances radiation-induced antitumor immunity. (PubMed, J Clin Invest)
    This process promotes the expression of T cell chemokines and upregulates the antigen presentation machinery, thereby enhancing radiation-induced CD8+ T cell antitumor immunity and radiotherapy efficacy. Our findings reveal a critical role of USP5 in type I IFN-induced antitumor immunity, providing potential targets for improving the efficacy of radiotherapy.
    Journal
    |
    CD8 (cluster of differentiation 8) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • STAT1 (Signal Transducer And Activator Of Transcription 1) • STAT2 (Signal transducer and activator of transcription 2) • USP5 (Ubiquitin Specific Peptidase 5)