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    BIOMARKER:

    SSTR2 underexpression

    i
    Other names: SSTR2, Somatostatin Receptor 2, Somatostatin Receptor Type 2, SRIF-1, SS2R, SS-2-R, SSTR2, SS2-R
    Entrez ID:
    6752
    Related biomarkers:
    Expression
    15d
    Preclinical safety and effectiveness of a long-acting somatostatin analogue [225Ac]Ac-EBTATE against small cell lung cancer and pancreatic neuroendocrine tumors. (PubMed, Eur J Nucl Med Mol Imaging)
    [225Ac]Ac-EBTATE is safe and effective against SCLC and pan-NET and therefore warrants clinical investigation.
    Preclinical • Journal
    |
    SSTR2 (Somatostatin Receptor 2)
    |
    SSTR2 expression • SSTR2 overexpression • SSTR2 underexpression
    |
    EBTATE
    1year
    Immunological role and prognostic value of somatostatin receptor family members in colon adenocarcinoma. (PubMed, Front Pharmacol)
    Our results identify SSTR2 as a promising target for COAD immunotherapy. Our findings provide new insights into the biological functions of the SSTR family and their implications for the prognosis of COAD.
    Journal • IO biomarker
    |
    SSTR (Somatostatin Receptor) • SSTR2 (Somatostatin Receptor 2) • ITGAX (Integrin Subunit Alpha X)
    |
    SSTR2 expression • SSTR Expression • SSTR2 underexpression
    1year
    Correlation between tumor invasion and somatostatin receptor subtypes in acromegaly. (PubMed, J Neurosurg)
    Tumor invasion is negatively correlated with SSTR2 level but is not associated with other SSTR subtypes. Patients with invasive tumors have a poorer response to SSA therapy, which may be due to the low level of SSTR2 expression. Therefore, SSTR2 could be considered as a routine investigative marker for aiding management of postoperative residual tumors.
    Journal
    |
    SSTR (Somatostatin Receptor) • IGF1 (Insulin-like growth factor 1) • SSTR2 (Somatostatin Receptor 2) • SSTR5 (Somatostatin Receptor 5)
    |
    SSTR2 expression • SSTR Expression • SSTR2 underexpression