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    GENE:

    SSH2 (Slingshot Protein Phosphatase 2)

    i
    Other names: SSH2, Slingshot Protein Phosphatase 2, KIAA1725, Protein Phosphatase Slingshot Homolog 2, SSH-Like Protein 2, SSH-2L, Slingshot Homolog 2 (Drosophila), HSSH-2L, SSH-2, SSH2L
    over1year
    Integrative analysis of single-nucleus RNA sequencing and Mendelian randomization to explore novel risk genes for Alzheimer's disease. (PubMed, Medicine (Baltimore))
    Except for the CACNA2D3 gene, the other 6 genes showed increased expression levels in the macrophages, particularly EPB41L2 and SSH2. Our findings highlight the potential of specific genetic markers identified through integrative analysis of sn-RNA-Seq and MR in guiding the diagnosis and therapeutic strategies for Alzheimer's disease.
    Journal
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    INPP5D (Inositol Polyphosphate-5-Phosphatase D) • SSH2 (Slingshot Protein Phosphatase 2)
    almost4years
    Concomitant novel ALK-SSH2, EML4-ALK and ARID2-ALK, EML4-ALK double-fusion variants and confer sensitivity to crizotinib in two lung adenocarcinoma patients, respectively. (PubMed, Diagn Pathol)
    Our study reported two novel ALK fusion partners never reported, which expands the knowledge of ALK fusion spectrum and provides insight into therapeutic options for patients with double ALK fusions.
    Journal
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    ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4) • ARID2 (AT-Rich Interaction Domain 2) • SSH2 (Slingshot Protein Phosphatase 2)
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    ALK rearrangement • ALK fusion
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    Xalkori (crizotinib)