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    GENE:

    SRSF5 (Serine And Arginine Rich Splicing Factor 5)

    i
    Other names: SRSF5, Serine And Arginine Rich Splicing Factor 5, SRP40, HRS, Splicing Factor, Arginine/Serine-Rich 5, Serine/Arginine-Rich Splicing Factor 5, SFRS5, Pre-MRNA-Splicing Factor SRP40, Delayed-Early Protein HRS, SR Splicing Factor 5
    Associations

    News

    Trials
    2years
    LINC01852 inhibits the tumorigenesis and chemoresistance in colorectal cancer by suppressing SRSF5-mediated alternative splicing of PKM. (PubMed, Mol Cancer)
    Our results demonstrate that LINC01852 plays an important role in repressing CRC malignancy and chemoresistance by regulating SRSF5-mediated alternative splicing of PKM, and that targeting the LINC01852/TRIM72/SRSF5/PKM2 signaling axis may represent a potential therapeutic strategy for CRC.
    Journal
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    PKM (Pyruvate Kinase M1/2) • SRSF5 (Serine And Arginine Rich Splicing Factor 5) • TRIM7 (Tripartite Motif Containing 7)
    2years
    Identification of SRSF10 as a promising prognostic biomarker with functional significance among SRSFs for glioma. (PubMed, Life Sci)
    Overall, this study uncovers the oncogenic roles of most SRSF family members in glioma, with the exception of SRSF5, while highlighting SRSF10 as a potential novel independent prognostic biomarker for glioma.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • BCLAF1 (BCL2 Associated Transcription Factor 1) • SRSF5 (Serine And Arginine Rich Splicing Factor 5)
    over2years
    Single-cell RNA sequencing identifies macrophage signatures correlated with clinical features and tumour microenvironment in meningiomas. (PubMed, IET Syst Biol)
    Our findings provide insights into the molecular characteristics underlying macrophage infiltration in meningiomas. The molecular signatures of macrophages demonstrate correlations with clinical features and immune cell infiltration in meningiomas.
    Journal
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    SPP1 (Secreted Phosphoprotein 1) • CDK1 (Cyclin-dependent kinase 1) • DDIT3 (DNA-damage-inducible transcript 3) • NFKBIA (NFKB Inhibitor Alpha 2) • SRSF5 (Serine And Arginine Rich Splicing Factor 5)
    over2years
    Inhibition of splicing factors SF3A3 and SRSF5 contributes to As/Se combination-mediated proliferation suppression and apoptosis induction in acute promyelocytic leukemia cells. (PubMed, Arch Biochem Biophys)
    Moreover, SRSF5 downregulation induced cell apoptosis through the activation of caspase-3. Taken together, these findings indicate that SF3A3 and SRSF5 function as pro-leukemic factors and can be potential novel therapeutic targets for APL.
    Journal
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    CASP3 (Caspase 3) • SRSF5 (Serine And Arginine Rich Splicing Factor 5)