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    BIOMARKER:

    SRRM4 overexpression

    i
    Other names: SRRM4, Serine/Arginine Repetitive Matrix 4, KIAA1853, NSR100, Neural-Specific SR-Related Protein Of 100 KDa, Neural-Specific Serine/Arginine Repetitive Splicing Factor Of 100 KDa, Serine/Arginine Repetitive Matrix Protein 4, Medulloblastoma Antigen MU-MB-2.76, MU-MB-2.76
    Entrez ID:
    84530
    over2years
    SRRM4-mediated REST to REST4 dysregulation promotes tumor growth and neural adaptation in breast cancer leading to brain metastasis. (PubMed, Neuro Oncol)
    Collectively, our findings identify SRRM4 as a regulator of brain metastasis colonization, and a potential therapeutic target in breast cancer.
    Journal
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    SRRM4 (Serine/Arginine Repetitive Matrix 4)
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    SRRM4 overexpression
    over2years
    High frequency of alternative splicing variants of the oncogene Focal Adhesion Kinase in neuroendocrine tumors of the pancreas and breast. (PubMed, Front Med)
    We explored the underlying mechanisms and found that a splicing factor serine/arginine repetitive matrix protein 4 (SRRM4) was overexpressed in FAK-positive pancreatic tumors and breast tumors, which promoted the formation of FAK in cells. These results suggested that FAK could be a biomarker of NENs and represent a potential therapeutic target for these orphan diseases.
    Journal
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    SRRM4 (Serine/Arginine Repetitive Matrix 4)
    |
    SRRM4 overexpression