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    BIOMARKER:

    SRC overexpression

    i
    Other names: SRC, SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase, V-Src Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog, Proto-Oncogene Tyrosine-Protein Kinase Src, Proto-Oncogene C-Src, P60-Src, SRC1, Protooncogene SRC, Rous Sarcoma, Tyrosine-Protein Kinase SRC-1, Tyrosine Kinase Pp60c-Src, Pp60c-Src, C-SRC, THC6, ASV
    Entrez ID:
    6714
    Related biomarkers:
    Mutation
    CNA
    Others
    almost2years
    Steroid Receptor Coactivator-1 (SRC-1) Promoted Cell Metastasis of Gastric Cancer via VEGFC Activator by NF-κB. (PubMed, Crit Rev Eukaryot Gene Expr)
    These results suggest that SRC-1 promoted cell metastasis of gastric cancer via VEGFC activator by NF-κB. These novel findings may shed further light on the pathogenesis of gastric cancer and on potential precursor markers.
    Journal
    |
    VEGFC (Vascular Endothelial Growth Factor C)
    |
    VEGFA overexpression • NFKB1 expression • VEGFA expression • SRC overexpression
    almost3years
    Src-1 and SP2 promote the proliferation and epithelial-mesenchymal transition of nasopharyngeal carcinoma. (PubMed, Open Med (Wars))
    Moreover, Src-1 interacted with SP2 to regulate EMT-related genes such as E-cad, N-cad, Vimentin, and ZEB1, and proliferation- and apoptosis-related genes, such as bax, cytochrome c, and cleaved caspase3 and bcl-2. Thus, blocking the interaction between Src-1 and SP2 may be a therapeutic target for inhibiting the metastasis of NPC.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • CASP3 (Caspase 3) • VIM (Vimentin) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)
    |
    SRC overexpression