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    BIOMARKER:

    SRC mutation

    i
    Other names: SRC, SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase, V-Src Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog, Proto-Oncogene Tyrosine-Protein Kinase Src, Proto-Oncogene C-Src, P60-Src, SRC1, Protooncogene SRC, Rous Sarcoma, Tyrosine-Protein Kinase SRC-1, Tyrosine Kinase Pp60c-Src, Pp60c-Src, C-SRC, THC6, ASV
    Entrez ID:
    6714
    Related biomarkers:
    Expression
    Mutation
    CNA
    Others
    2years
    Simulating androgen receptor selection in designer yeast. (PubMed, Synth Syst Biotechnol)
    This assay is applicable to determine a wide range of clinical AR mutants including those with loss of function relating to androgen insensitivity syndrome (AIS), and those associated with PCa conferring resistance to AR antagonists such as enzalutamide (ENZ), bicalutamide (BIC), and cyproterone acetate (CPA). One clinical AR mutant previously reported to confer ENZ-resistance, F877L, was found to confer partial resistance to CPA as well using designer yeast. Our simple and efficient assay can enable precise one-pot screening of AR mutants, providing a reference for tailored medicine.
    Journal
    |
    AR (Androgen receptor)
    |
    AR mutation • AR F877L • SRC mutation
    |
    Xtandi (enzalutamide capsule) • bicalutamide • cyproterone acetate