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    BIOMARKER:

    SPRED2 deletion

    i
    Other names: SPRED2, Sprouty Related EVH1 Domain Containing 2, Spred-2, Sprouty-Related, EVH1 Domain-Containing Protein 2, FLJ21897, FLJ31917, Sprouty Protein With EVH-1 Domain 2, Related Sequence
    Entrez ID:
    200734
    24d
    Expression of SPRED2 in the lung adenocarcinoma. (PubMed, Pathol Res Pract)
    In vitro, SPRED2 deletion increased cell proliferation, migration and invasion of three LUAD cell lines (A549:KRAS mutation, H1993:METamplification, and HCC4006:EGFR mutation), whereas SPRED2 overexpression decreased these responses. Thus, SPRED2 appears to be a regulator of LUAD progression and a potential target for the treatment of LUAD.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • SPRED2 (Sprouty Related EVH1 Domain Containing 2)
    |
    KRAS mutation • EGFR mutation • MET amplification • SPRED2 deletion