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    DRUG:

    SPR1-0117

    i
    Other names: SPR1-0117, SPR1
    Associations

    News

    Trials
    Company:
    Sporos Bio
    Drug class:
    TEAD1 inhibitor, TEAD inhibitor, TEAD4 inhibitor
    Related drugs:
    Associations

    News

    Trials
    almost2years
    A next generation TEAD inhibitor with refined isoform specificity for superior safety & efficacy (AACR 2023)
    (iv) favorable ADME profile in rodents, dogs and NHPs, as well as a favorable safety profile. In sum, SPR1 presents monotherapy opportunities in ultra-responder populations based on internal bioinformatic insights, while broader potential exists as an adjuvant for precision oncology targeted therapies, particularly within the MAPK pathway and its upstream activators.
    Clinical
    |
    YAP1 (Yes associated protein 1) • WWTR1 (WW Domain Containing Transcription Regulator 1) • TEAD1 (TEA Domain Transcription Factor 1)
    |
    SPR1-0117