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BIOMARKER:

SPP1-H

i
Other names: SPP-1, BSPI, Secreted Phosphoprotein 1, Osteopontin, Early T-Lymphocyte Activation 1, Urinary Stone Protein, Nephropontin, Uropontin, BNSP, OPN, Secreted Phosphoprotein 1 (Osteopontin, Bone Sialoprotein I, Early T-Lymphocyte Activation 1), Osteopontin/Immunoglobulin Alpha 1 Heavy Chain Constant Region Fusion Protein, Secreted Phosphoprotein 1 Variant 6, SPP1/CALPHA1 Fusion, Bone Sialoprotein 1, Bone Sialoprotein I, ETA-1
Entrez ID:
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Trials
29d
Single-cell RNA Sequencing Reveals Distinct Populations of Tumor Associated Macrophages in Colorectal Metastasis. (SSO 2023)
Deconvolution of CRC metastasis at a single-cell resolution deepens our understanding of functional heterogeneity of TAMs and their variable expression patterns in hematogenous and peritoneal metastases. Our findings may partially explain the differences in the tumor biology, treatment response, and clinical outcomes between CPM and HM. Learning Objectives: understand the role of Tumor-associated Macrophages (TAMs) in progression of metastatic Colorectal Cancer (mCRC) describe Single cell sequencing in metastatic Colorectal Cancer (mCRC) understand the differences survival outcomes on the basis of tumor microenvironment
Clinical
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SPP1 (Secreted Phosphoprotein 1) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3)
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SPP1-H • SPP1-L
6ms
Single-Cell Transcriptome Analysis of Radiation Pneumonitis Mice. (PubMed, Antioxidants (Basel))
We also calculated the enrichment of a cGAS-STING signaling pathway, which may be involved in regulating inflammatory responses and cancer progression in AT2 cells of PR mice. We delineate markers and transcriptional states, identify a type 2 alveolar cell, and uncover fundamental determinants of lung fibrosis and inflammatory response in RP lung tissue of mice.
Preclinical • Journal
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FABP4 (Fatty Acid Binding Protein 4)
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SPP1-H
1year
Attenuation of the Apoptosis Stimulating Protein of TP53-1 (ASPP1) Is a Predictive Marker for Therapy Resistance and Overall Survival in Acute Myeloid Leukemia (AML) (ASH 2021)
As expected, cells were more chemo-susceptible when exposed to decitabine followed by daunorubicin and cytarabine in an ASPP1-dependent manner: MOLM-14.ASPP1i cell line strains did not reveal a significant change of proapoptotic efficacy when compared to mock strains which significantly benefitted from this approach with more than doubled proapoptotic rates (**** p < 0.0001, t-test), again confirming ASPP1 target specificity. Prospective clinical studies are warranted to evaluate the role as a biomarker for risk stratification. Further, we provide a rationale to re-sensitize high-risk patients (defined as ASPP1 low-expressors) towards chemotherapy using HMA priming upfront – and this strategy should be followed in future trials.
Clinical
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TP53 (Tumor protein P53)
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SPP1-H • SPP1-L
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cytarabine • decitabine • daunorubicin
over1year
The Correlation Between SPP1 and Immune Escape of EGFR Mutant Lung Adenocarcinoma Was Explored by Bioinformatics Analysis. (PubMed, Front Oncol)
Furthermore, we found that the SPP1 expression was positively correlated with CD276, especially in patients with EGFR mutation. SPP1 levels might be a useful marker of immunosuppression in patients with EGFR mutation, and could offer insight for therapeutics.
Journal • PD(L)-1 Biomarker • IO biomarker
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EGFR (Epidermal growth factor receptor) • PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • CD276 (CD276 Molecule) • SPP1 (Secreted Phosphoprotein 1)
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PD-L1 expression • EGFR mutation • EGFR expression • SPP1-H • SPP1-L