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GENE:

SPOCD1 (SPOC Domain Containing 1)

News alerts, weekly reports and conference planners

3ms

SPOCD1 Aggravates Tumor Growth and Metastasis in Oral Squamous Cell Carcinoma. (PubMed, J Oral Pathol Med)

This study demonstrates that SPOCD1 promotes OSCC growth and metastasis by activating the PI3K/Akt/mTOR pathway, indicating that SPOCD1 may represent a potential therapeutic target for OSCC treatment.

3 months ago

Journal

SPOCD1 (SPOC Domain Containing 1)

4ms

SPOCD1 expression in clear cell renal cell carcinoma: its implications for the prognosis and immunotherapy. (PubMed, World J Surg Oncol)

SPOCD1 represents a potential prognostic indicator for patients with ccRCC. Elevated SPOCD1 expression is strongly associated with unfavorable clinicopathological features, poorer survival outcomes, and increased immune cell infiltration in ccRCC.

4 months ago

Journal • IO biomarker

SPOCD1 (SPOC Domain Containing 1)

6ms

Cancer cell SPOCD1 promotes colorectal cancer liver metastasis by activating the CXCL12/CXCR4 signaling pathway in cancer-associated fibroblasts. (PubMed, J Transl Med)

This study delineates a SPOCD1-centered interaction network between CRC cells and CAFs in colorectal cancer liver metastasis (CRLM), offering novel molecular candidates for therapeutic intervention in CRLM.

6 months ago

Journal

CXCR4 (Chemokine (C-X-C motif) receptor 4) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • DNMT1 (DNA methyltransferase 1) • SPOCD1 (SPOC Domain Containing 1)

7ms

Intratumoral Microbe Correlated with Expression of DNA Methylation Genes in Hepatocellular Carcinoma. (PubMed, Dig Dis Sci)

The identified microbiota-gene interactions reveal potential mechanistic links between intratumor flora and HCC progression via DNA methylation regulation. These findings highlight novel targets for further exploration of HCC therapeutic strategies.

7 months ago

Journal

BMI1 (BMI1 proto-oncogene, polycomb ring finger) • SPOCD1 (SPOC Domain Containing 1)

12ms

SPOCD1 Enhances Cancer Cell Activities and Serves as a Prognosticator in Esophageal Squamous Cell Carcinoma. (PubMed, Cancer Genomics Proteomics)

SPOCD1 expression correlates with the aggressiveness of ESCC cells, and its expression levels in tumor tissues may serve as a prognostic factor for ESCC patients.

12 months ago

Journal

SPOCD1 (SPOC Domain Containing 1)

1year

IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A. (PubMed, Cell Death Discov)

Thus, IFNγ signaling paired with SPOCD1 is a natural keloid ferroptosis promoting mechanism and a mode of action of CTLs. Targeting SPOCD1 pathway is a potential anti-keloid approach.

1 year ago

Journal

DNMT3A (DNA methyltransferase 1) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • SPOCD1 (SPOC Domain Containing 1)

over1year

Investigation of SPOCD1 as A Suitable Diagnostic and Prognostic Biomarker in Various Common Cancer Types: Bioinformatics and Practical Analysis. (PubMed, Cell J)

This study confirms the potential of SPOCD1 as a diagnostic and prognostic biomarker in prevalent cancers. However, extensive clinical data, particularly for CRC, are required to validate its reliability. Different COAD subtypes may exhibit varying correlations with SPOCD1 expression levels, underscoring the need for further investigation to fully understand its diagnostic and prognostic value.

over 1 year ago

Journal

SPOCD1 (SPOC Domain Containing 1)

Gomekli (mirdametinib) • Farydak (panobinostat)

over2years

Next Generation Sequencing of Subcutaneous Panniculitis-Like T-Cell Lymphoma (ASDP 2023)

Future studies will include testing on older cases to evaluate for HAVCR2. Poster type: Poster Defense

over 2 years ago

Next-generation sequencing

DNMT3A (DNA methyltransferase 1) • PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • ETV6 (ETS Variant Transcription Factor 6) • CREBBP (CREB binding protein) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • SETD2 (SET Domain Containing 2, Histone Lysine Methyltransferase) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • RHOA (Ras homolog family member A) • CSF1R (Colony stimulating factor 1 receptor) • SOCS1 (Suppressor Of Cytokine Signaling 1) • CALR (Calreticulin) • PRDM1 (PR/SET Domain 1) • SPOCD1 (SPOC Domain Containing 1) • ZNF384 (Zinc Finger Protein 384)

DNMT3A mutation

over2years

Development of a novel tumor microenvironment-related radiogenomics model for prognosis prediction in hepatocellular carcinoma. (PubMed, Quant Imaging Med Surg)

Moreover, the model showed that higher radiogenomics scores were associated with worse OS and lower levels of immune infiltration. The novel CECT-based radiogenomics model may provide valuable insights for prognostic stratification and TME assessment of patients with HCC.

over 2 years ago

Journal

KLRB1 (Killer Cell Lectin Like Receptor B1) • SPOCD1 (SPOC Domain Containing 1)

almost3years

Prognostic Biomarker SPOCD1 and Its Correlation with Immune Infiltrates in Colorectal Cancer. (PubMed, Biomolecules)

Furthermore, our findings suggested a possible function for SPOCD1 in the polarization of macrophages from M1 to M2 in CRC. In conclusion, SPOCD1 is a promising diagnostic and prognostic marker for CRC, opening new avenues for research and treatment.

almost 3 years ago

Journal

SPOCD1 (SPOC Domain Containing 1)