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    DRUG:

    spliceostatin A (SSA)

    i
    Other names: SSA
    Company:
    Riken
    Drug class:
    SF3B1 inhibitor, RNA splicing modulator
    Related drugs:
    11ms
    Design and synthesis of 4-acetoxypentanamide derivatives of spliceostatin A and their biological evaluation towards prostate cancer treatment. (PubMed, Bioorg Med Chem Lett)
    We designed and synthesized novel 4-acetoxypentanamide derivatives of spliceostatin A, whose 4-acetoxypentenamide moiety is reduced (7), isomerized (8), or substituted with methyl at the α-position (9). The results of biological evaluation against AR-V7 and the docking analysis of each derivative suggest that the geometry of the 4-acetoxypentenamide moiety of spliceostatin A is important for its biological activity.
    Journal
    |
    AR (Androgen receptor)
    |
    AR splice variant 7
    |
    spliceostatin A (SSA)