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GENE:

SPI1 (Spi-1 Proto-Oncogene)

News alerts, weekly reports and conference planners

CircSMAD4 shapes matrix-remodeling TAMs in lung adenocarcinoma. (PubMed, Noncoding RNA Res)

In parallel, circSMAD4 formed a specific ribonucleoprotein complex with the m6A reader IGF2BP2, facilitating IGF2BP2 association with COL4A1, ACTA2, and SPI1 transcripts and enhancing their m6A-dependent stability. Together, these dual branches converge on a matrix-remodeling output, positioning circSMAD4 as a post-transcriptional hub that reinforces protumor TAM programs in LUAD and a potential target for microenvironment-directed therapy.

3 days ago

Journal

ACTA2 (Actin Alpha 2 Smooth Muscle) • SPI1 (Spi-1 Proto-Oncogene) • COL4A1 (Collagen Type IV Alpha 1 Chain) • IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2)

20d

Spi-1 proto-oncogene regulates mRNA hypertranscription and malignant progression in head and neck cancer. (PubMed, Signal Transduct Target Ther)

Mechanistically, inducible SPI1 overexpression elevated nascent RNA synthesis as measured by EU incorporation, and integrative ChIP-seq/RNA-seq profiling identified direct genomic targets of SPI1 enriched in oncogenic transcriptional programs. Collectively, our findings show that SPI1-driven mRNA hypertranscription is important in HNSCC progression and provide novel insights into the transcriptional dysregulation underlying aggressive malignancies.

20 days ago

Journal

SPI1 (Spi-1 Proto-Oncogene)

24d

Ziyuglycoside II ameliorates chemotherapy-induced neutropenia by promoting neutrophil differentiation and functional recovery via SPI1 and C/EBPϵ transcriptional regulation. (PubMed, Front Immunol)

This study aims to assess the efficacy of ZGSII in mitigating cyclophosphamide-induced neutropenia and myelosuppression and to elucidate the underlying mechanism involved through transcriptome sequencing, protein-protein interaction network construction, and functional validation assays...ZGSII alleviates CIN by regulating SPI1 and C/EBPϵ transcriptional activity to promote neutrophil differentiation and functional recovery. These findings provides a preclinical proof for ZGSII as a therapeutic adjuvant or alternative treatment option for CIN.

24 days ago

Journal

SPI1 (Spi-1 Proto-Oncogene)

cyclophosphamide

Integrated transcriptomics and molecular docking identify hub genes and statin regulators in Helicobacter pylori-associated gastric mucosal pathogenesis. (PubMed, Front Cell Infect Microbiol)

To explore potential therapeutic interventions, we performed small-molecule drug prediction and molecular docking for hub genes revealed: Simvastatin: Linked to CCL20, NFKBIA, and ICAM1. Atorvastatin: Associated with CDKN1A, ICAM1, and TNF. TPCA-1: Targeting JAK1. These findings provide a theoretical foundation for further investigation into the molecular mechanisms underlying H. pylori-related diseases.

1 month ago

Journal

BRCA1 (Breast cancer 1, early onset) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • BIRC3 (Baculoviral IAP repeat containing 3) • JAK1 (Janus Kinase 1) • TNFAIP3 (TNF Alpha Induced Protein 3) • CCL20 (C-C Motif Chemokine Ligand 20) • ICAM1 (Intercellular adhesion molecule 1) • IRF1 (Interferon Regulatory Factor 1) • ITGAM (Integrin, alpha M) • SPI1 (Spi-1 Proto-Oncogene) • ETS1 (ETS Proto-Oncogene 1) • IL17A (Interleukin 17A) • STAT1 (Signal Transducer And Activator Of Transcription 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • NFKB2 (Nuclear Factor Kappa B Subunit 2) • NFKBIA (NFKB Inhibitor Alpha 2) • NFKBIE (NFKB Inhibitor Epsilon) • TRAF1 (TNF Receptor Associated Factor 1) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • E2F1 (E2F transcription factor 1) • EGR1 (Early Growth Response 1) • HSF1 (Heat Shock Transcription Factor 1) • JUNB (JunB Proto-Oncogene AP-1 Transcription Factor Subunit)

simvastatin • atorvastatin

BCL11B enhancer hijacking by t(14;16)(q32;q24) translocation defines a novel high-risk subtype of T-ALL. (PubMed, Blood)

Importantly, patients with t(14;16)(q32;q24) have an extremely poor prognosis, showing a trend toward worse outcomes than high-risk groups such as KMT2A-rearranged early T-cell progenitor (ETP)-like, SPI1-rearranged, and LMO2 γδ-like T-ALLs. The unique molecular landscape and poor prognosis of patients with the t(14;16)(q32;q24) translocation underscore the need for the development of novel subtype-specific therapeutic approaches.

1 month ago

Journal

CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • KMT2A (Lysine Methyltransferase 2A) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • CD34 (CD34 molecule) • SPI1 (Spi-1 Proto-Oncogene) • LMO2 (LIM Domain Only 2) • BCL11B (BAF Chromatin Remodeling Complex Subunit BCL11B) • GATA3 (GATA binding protein 3) • FOXC2 (Forkhead Box C2)

CDKN2A deletion

Single-nucleus atlas provides insights into changes in the evolution of the pig hippocampus. (PubMed, BMC Biol)

This study offers insights into hippocampal function regulation in pigs, focusing on stress resilience, behavior, and productivity. It highlights conserved and breed-specific molecular features of hippocampal cell types and their roles in adaptability and mental health. By integrating single-nucleus data, the research suggests that genetic strategies could be used to improve animal welfare, stress management, and production efficiency in pig breeding programs.

1 month ago

Journal

ABCG2 (ATP Binding Cassette Subfamily G Member 2) • SPP1 (Secreted Phosphoprotein 1) • GATA2 (GATA Binding Protein 2) • SPI1 (Spi-1 Proto-Oncogene) • TGFB1 (Transforming Growth Factor Beta 1) • EBF1 (EBF Transcription Factor 1) • APOE (Apolipoprotein E)

2ms

Palmitoylation modification of SPI1 promotes nasopharyngeal carcinoma radioresistance through inhibiting c-CBL-mediated ubiquitination and degradation. (PubMed, Drug Resist Updat)

Collectively, our findings suggest that SPI1 palmitoylation inhibits c-CBL-mediated ubiquitination and degradation, thereby enhancing SPI1 protein stability and its transcriptional regulation of miR-205-5p. Upregulated miR-205-5p in NPC cells is packaged into exosomes and transferred to endothelial cells, where it targets and inhibits WWC2 expression, eventually promoting angiogenesis and NPC radioresistance.

2 months ago

Journal

SPI1 (Spi-1 Proto-Oncogene) • WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2) • MIR205 (MicroRNA 205)

2ms

Single-cell RNA sequencing unveils CCDC86-driven immune modulation and antigen-presenting cell dynamics in head and neck squamous cell carcinoma. (PubMed, Discov Oncol)

CCDC86 acts as a key regulator of immune communication in HNSCC, orchestrating APC-T cell interactions and shaping an immunoregulatory niche. By linking antigen presentation with checkpoint signaling, CCDC86 contributes to immune evasion while maintaining local immune activation. These findings highlight CCDC86 as a promising prognostic biomarker and potential immunotherapeutic target in HNSCC.

2 months ago

Journal • PD(L)-1 Biomarker • IO biomarker

PD-1 (Programmed cell death 1) • CCDC6 (Coiled-Coil Domain Containing 6) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • SPI1 (Spi-1 Proto-Oncogene) • CCDC86 (Coiled-Coil Domain Containing 86) • CD86 (CD86 Molecule)

2ms

Copy-number amplification drives IFI30 overexpression and coordinated immune activation, identifying a novel diagnostic and therapeutic target in gastric adenocarcinoma. (PubMed, Sci Rep)

Its high expression integrates tumor-intrinsic programs (cell cycle, EMT, hypoxia) with tumor-extrinsic immune activation, predicts differential drug sensitivities, and outperforms established biomarkers in forecasting response to immune-checkpoint blockade-particularly in MSI-high disease. These findings nominate IFI30 as a promising diagnostic marker and therapeutic target.

2 months ago

Journal • Tumor mutational burden • MSi-H Biomarker • PD(L)-1 Biomarker • IO biomarker

EGFR (Epidermal growth factor receptor) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • MSI (Microsatellite instability) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • IRF1 (Interferon Regulatory Factor 1) • SPI1 (Spi-1 Proto-Oncogene) • FOXP3 (Forkhead Box P3)

MSI-H/dMMR

2ms

Analysis of the Relationship Between Early Estrogen Response and Cryptorchidism. (PubMed, Endocr Metab Immune Disord Drug Targets)

This study provided translational insights, enhancing the current understanding of testicular pathogenesis and contributing to the diagnosis and treatment of cryptorchidism.

2 months ago

Journal

SPI1 (Spi-1 Proto-Oncogene)

3ms

The long noncoding RNA VIM-AS1 and nucleoporin Nup358/RanBP2 regulate SMAD nuclear accumulation during TGF-β signaling. (PubMed, Nucleic Acids Res)

In the context of cancer biology, VIM-AS1 did not affect the antiproliferative actions of TGF-β, yet had an impact on the epithelial-mesenchymal transition gene program, and increased the invasion and motility of tumor cells, whereas its silencing sensitized cancer cells to chemotherapeutic agents. The molecular mechanism highlights how a lncRNA can modulate the nuclear pore's capacity to import SMAD complexes, by facilitating their capture by Nup358/RanBP2 and thereby enhancing nuclear accumulation of SMADs with distinct isoform composition, thus promoting selectively TGF-β signaling responses.

3 months ago

Journal

RANBP2 (RAN Binding Protein 2) • GATA6 (GATA Binding Protein 6) • VIM (Vimentin) • SPI1 (Spi-1 Proto-Oncogene) • TGFB1 (Transforming Growth Factor Beta 1) • SMAD2 (SMAD Family Member 2) • VIM-AS1 (VIM Antisense RNA 1)

3ms

Spil-mediated sEH overexpression contributes to the senescence of alveolar epithelial cells during pulmonary fibrosis in mice. (PubMed, J Mol Med (Berl))

We have reported that EETs inhibit AEC senescence, alleviating bleomycin (BLM)-induced PF in mice...Inhibition of Spi1 significantly attenuated AEC senescence. Inhibition of Spi1 alleviated pulmonary fibrosis in aging mice.

3 months ago

Preclinical • Journal

SPI1 (Spi-1 Proto-Oncogene)

bleomycin