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    BIOMARKER:

    SPI1 overexpression

    i
    Other names: SPI1, Spi-1 Proto-Oncogene, Hematopoietic Transcription Factor PU.1, 31 KDa Transforming Protein, Transcription Factor PU.1, Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene Spi1, Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene, 31 KDa-Transforming Protein, SFPI1, SPI-1, SPI-A, PU.1, OF
    Entrez ID:
    6688
    Related biomarkers:
    CNA
    20d
    SPI1+CD68+ macrophages as a biomarker for gastric cancer metastasis: a rationale for combined antiangiogenic and immunotherapy strategies. (PubMed, J Immunother Cancer)
    The present study showed that SPI1+CD68+ TAMs are a promising biomarker for predicting prognosis, antiangiogenic drug sensitivity, and combination target of immunotherapy in patients with GC.
    Journal • IO biomarker
    |
    CD68 (CD68 Molecule) • SPI1 (Spi-1 Proto-Oncogene)
    |
    SPI1 overexpression
    8ms
    SPI1 exacerbates iron accumulation and promotes osteoclast formation through inhibiting the expression of Hepcidin. (PubMed, Mol Cell Endocrinol)
    Therefore, the study revealed that SPI1 could inhibit Hepcidin expression contribute to iron accumulation and osteoclast formation via DMT1 signaling activation in mouse with OVX.
    Journal
    |
    CSF1 (Colony stimulating factor 1) • SPI1 (Spi-1 Proto-Oncogene) • MMP9 (Matrix metallopeptidase 9) • DMRT1 (Doublesex And Mab-3 Related Transcription Factor 1) • FOS (Fos Proto-Oncogene AP-1 Transcription Factor Subunit 2)
    |
    SPI1 overexpression
    1year
    IRF1 suppresses colon cancer proliferation by reducing SPI1-mediated transcriptional activation of GPX4 and promoting ferroptosis. (PubMed, Exp Cell Res)
    Through this mechanism, IRF1 can enhance erastin-induced ferroptosis of colon cancer. The IRF1/SPI1-GPX4 axis might play a crucial role in modulating ferroptosis in colon cancer and might serve as a potential therapeutic target in the future.
    Journal
    |
    GPX4 (Glutathione Peroxidase 4) • IRF1 (Interferon Regulatory Factor 1) • SPI1 (Spi-1 Proto-Oncogene)
    |
    IRF1 expression • GPX4 expression • SPI1 overexpression
    |
    erastin
    over1year
    SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer Progression via PI3K/AKT/mTOR Pathway. (PubMed, Can J Gastroenterol Hepatol)
    Overexpressed NMT1 reversed the effects of shSPI1 on decreasing viability, migration, invasion, p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR in GC cells, and NMT1 knockdown reversed the effects of SPI1 overexpression on increasing viability, migration, invasion, p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR. SPI1 upregulated NMT1 to facilitate the malignant behaviors of GC cells through the PI3K/AKT/mTOR pathway.
    Journal
    |
    SPI1 (Spi-1 Proto-Oncogene)
    |
    SPI1 overexpression
    almost2years
    Implication of lncRNA ZBED3-AS1 downregulation in acquired resistance to Temozolomide and glycolysis in glioblastoma. (PubMed, Eur J Pharmacol)
    Either ZBED3-AS1 overexpression or SPI1 knockdown in U87/TMZ cells blocked the growth of orthotopic and subcutaneous xenograft tumors in nude mice. In conclusion, this study demonstrates that ZBED3-AS1 downregulation and THBD activation is linked to increased TMZ resistance and glycolysis in GBM cells.
    Preclinical • Journal
    |
    SPI1 (Spi-1 Proto-Oncogene) • THBD (Thrombomodulin)
    |
    SPI1 overexpression
    |
    temozolomide
    2years
    Endothelial cell-specific molecule 1 (ESM1) promoted by transcription factor SPI1 acts as an oncogene to modulate the malignant phenotype of endometrial cancer. (PubMed, Open Med (Wars))
    Overexpressed SPI1 promoted the expression of ESM1 and induced malignant phenotype (viability, proliferation, and invasion), which were countervailed by ESM1 silencing. Collectively, ESM1 induced by SPI1 promotes the malignant phenotype of EC.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • KDR (Kinase insert domain receptor) • CDH1 (Cadherin 1) • FLT1 (Fms-related tyrosine kinase 1) • VIM (Vimentin) • SPI1 (Spi-1 Proto-Oncogene) • CDH2 (Cadherin 2) • PCNA (Proliferating cell nuclear antigen)
    |
    CDH1 expression • SPI1 overexpression • VIM expression • FLT1 expression • PCNA expression