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    BIOMARKER:

    SPI1 deletion

    i
    Other names: SPI1, Spi-1 Proto-Oncogene, Hematopoietic Transcription Factor PU.1, 31 KDa Transforming Protein, Transcription Factor PU.1, Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene Spi1, Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene, 31 KDa-Transforming Protein, SFPI1, SPI-1, SPI-A, PU.1, OF
    Entrez ID:
    6688
    Related biomarkers:
    Expression
    over2years
    Hyper-radiosensitivity affects low-dose acute myeloid leukemia incidence in a mathematical model. (PubMed, Radiat Environ Biophys)
    In conclusion, cellular HRS affects the number of surviving pre-leukemic cells with an Sfpi1 deletion which, depending on the HRS assumption, directly translates to a lower/higher probability of developing rAML. Low-dose HRS may affect cancer risk in general by altering the probability that certain mutations occur/persist.
    Journal
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    SPI1 (Spi-1 Proto-Oncogene)
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    SPI1 deletion
    almost4years
    Modeling low-dose radiation-induced acute myeloid leukemia in male CBA/H mice. (PubMed, Radiat Environ Biophys)
    After making only model-derived high-dose rAML estimates available to extrapolate from, the linear-quadratic model could be used to approximate low-dose rAML incidence calculated with our mouse model. The accuracy in estimating low-dose rAML incidence when extrapolating from a linear model using a low-dose effectiveness factor was found to depend on whether a data transformation was used in the curve fitting procedure.
    Journal
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    SPI1 (Spi-1 Proto-Oncogene)
    |
    SPI1 deletion