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    GENE:

    SPEN (Spen Family Transcriptional Repressor)

    i
    Other names: SPEN, Spen Family Transcriptional Repressor, SHARP, MINT, SMART/HDAC1-Associated Repressor Protein, Msx2-Interacting Protein, RBM15C, SPEN Homolog, Transcriptional Regulator (Drosophila), Spen Homolog, Transcriptional Regulator (Drosophila), Msx2 Interacting Nuclear Target (MINT) Homolog, Nuclear Receptor Transcription Cofactor, Spen Homolog, Transcriptional Regulator, SPEN Homolog
    2years
    The Role of SPEN Mutations as Predictive Biomarkers for Immunotherapy Response in Colorectal Cancer: Insights from a Retrospective Cohort Analysis. (PubMed, J Pers Med)
    We conclude that SPEN mutations might improve ICI efficacy in CRC due to increased immunogenicity and an inflammatory tumor microenvironment. SPEN mutations could be predictive biomarkers for ICI responsiveness, underscoring their value in personalized therapy and highlighting the importance of genomic data in clinical decisions. This research lays the groundwork for future precision oncology studies.
    Retrospective data • Journal • Tumor mutational burden • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • TP53 (Tumor protein P53) • TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • CD8 (cluster of differentiation 8) • SPEN (Spen Family Transcriptional Repressor)
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    PD-L1 expression • TP53 mutation • SPEN mutation
    almost4years
    A VDAC1-mediated NEET protein chain transfers [2Fe-2S] clusters between the mitochondria and the cytosol and impacts mitochondrial dynamics. (PubMed, Proc Natl Acad Sci U S A)
    Additionally, we show that modifying MiNT expression in breast cancer cells affects the dynamics of mitochondrial structure and morphology, mitochondrial function, and breast cancer tumor growth. Our findings reveal a pathway for the transfer of [2Fe-2S] clusters, which are assembled inside the mitochondria, to the cytosol.
    Journal
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    SPEN (Spen Family Transcriptional Repressor)