SPEG (Striated Muscle Enriched Protein Kinase)

These findings provide preliminary evidence supporting further investigation of sex-specific approaches to BC management.

Potential tumor-suppressing properties have been revealed through OBSCN lncRNAs and epigenetic regulation. This review aims to provide a comprehensive overview of obscurin's molecular functions and interactions by discussing the effects of its differential expression and its interactions with binding partners, along with the differences and similarities between vertebrate and invertebrate obscurin.

The results suggest that distinct tumor progression pathways account for different chronicity outcomes further affecting patients' survival. However, larger studies are needed incorporating transcriptomic and epigenomic data to shed further light on the mechanistic chain from mutations to downstream gene expression regulation.

In this study, an efficiency delivery system with a pH-triggered detachable PEG layer (sPEG) and a folic acid (FA)-modified cationic liposome core (FLip) is constructed for codelivering doxorubicin (DOX) and METTL3 siRNA (siMETTL3)...As a result, the levels of drug resistance-related proteins in tumors are significantly downregulated, and the enhanced chemotherapy and suppressed DOX resistance demonstrate superior tumor suppression in MCF-7/ADR tumor-bearing mice. This sequential therapy provides a reliable approach for improving cancer chemotherapy with suppressed DOX resistance by destroying the N6 methyladenosine (m6A) methylation, which may extremely benefit the future design of smart drug delivery systems.

iSDSE incidence is increasing and is associated with older patients with comorbidities. Genetically, SDSE is diverse with a high capacity to integrate MGEs carrying resistance determinants. Mouse model studies showed the enhanced virulence of the CC20-stG62647 lineage. These findings underscore the need for ongoing surveillance of this emerging pathogen.

In the past decade, high-throughput quantitative proteome profiling tools have significantly renewed our interest in discovering novel cancer diagnostic or prognostic biomarkers through the simultaneous examination of the enormous amount of high-quality data of thousands of proteins and genes in complex biological systems. In this chapter, we describe how aberrant N-linked glycopeptides could be selectively identified as novel single tumor markers through the use of mass spectrometry (MS)-based proteomics, also known as Solid-phase extraction of N-glycopeptides (SPEG), and reasonable hypotheses that have the potential capacity to revolutionize biomarker discovery and bring those markers to the clinic as early as possible.

In an orthotopic ATC xenograft model, Pt@TAT/sPEG demonstrates superior tumor growth suppression compared to Pt@sPEG and cisplatin. This nanostrategy offers a feasible approach to simultaneously inhibit glycolysis and DNA repair for metabolic reprogramming and enhanced tumor chemotherapy.