SPATS2L (Spermatogenesis Associated Serine Rich 2 Like)

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7ms

Identification of Molecular Subtypes of B-Cell Acute Lymphoblastic Leukemia in Mexican Children by Whole-Transcriptome Analysis. (PubMed, Int J Mol Sci)

Here, we have demonstrated the importance of using RNA-seq to facilitate the differential diagnosis of B-ALL with successful detection of gene fusions and mutations. This will aid both patient risk stratification and precision medicine.

7 months ago

Journal

FLT3 (Fms-related tyrosine kinase 3) • NRAS (Neuroblastoma RAS viral oncogene homolog) • JAK2 (Janus kinase 2) • RUNX1 (RUNX Family Transcription Factor 1) • KMT2A (Lysine Methyltransferase 2A) • ETV6 (ETS Variant Transcription Factor 6) • CRLF2 (Cytokine Receptor Like Factor 2) • NT5C2 (5'-Nucleotidase Cytosolic II) • SETD2 (SET Domain Containing 2, Histone Lysine Methyltransferase) • TCF3 (Transcription Factor 3) • PBX1 (PBX Homeobox 1) • TYK2 (Tyrosine Kinase 2) • SEMA6A (Semaphorin 6A) • STAT2 (Signal transducer and activator of transcription 2) • DUX4 (Double Homeobox 4) • RAG1 (Recombination Activating 1) • ZNF384 (Zinc Finger Protein 384) • SPATS2L (Spermatogenesis Associated Serine Rich 2 Like)

1year

Single-cell transcriptomics reveals heterogeneity and prognostic markers of myeloid precursor cells in acute myeloid leukemia. (PubMed, Front Immunol)

This study provides a new approach to AML prognostic assessment and reveals the role of key genes in AML. These genes may become new biomarkers and therapeutic targets that can help improve prognostic prediction and personalized treatment of AML.

1 year ago

Journal

CD34 (CD34 molecule) • IRF8 (Interferon Regulatory Factor 8) • SPINK2 (Serine Peptidase Inhibitor Kazal Type 2) • ARHGAP5 (Rho GTPase Activating Protein 5) • SPATS2L (Spermatogenesis Associated Serine Rich 2 Like)

almost2years

Unlocking the potential: A novel prognostic index signature for acute myeloid leukemia. (PubMed, Comput Biol Med)

Finally, to facilitate broader access to our findings, a user-friendly and publicly accessible webserver was established and available at http://bioinfor.imu.edu.cn/amlpi. This server provides tools including TME-related AML driver genes mining, AMLPI construction, multi-dimensional validations, AML patients risk assessment, and figures drawing.

almost 2 years ago

Journal • PD(L)-1 Biomarker • IO biomarker

TP53 (Tumor protein P53) • NPM1 (Nucleophosmin 1) • PD-1 (Programmed cell death 1) • ALDH2 (Aldehyde Dehydrogenase 2 Family Member) • SPATS2L (Spermatogenesis Associated Serine Rich 2 Like)

TP53 mutation • NPM1 mutation • PD-1 expression

over2years

IGJ and SPATS2L immunohistochemistry sensitively and specifically identify BCR::ABL1+ and BCR::ABL1-like B-acute lymphoblastic leukaemia. (PubMed, Br J Haematol)

The presence of either IGJ or SPATS2L staining augments the sensitivity (93%) and NPV (95%). While these findings would need to be validated in larger studies, they suggest that IGJ and/or SPATS2L IHC may be utilized in identifying BCR::ABL1-like B-ALL or in selecting B-ALL cases for confirmatory molecular/genetic testing, particularly in resource-limited settings.

over 2 years ago

Journal

ABL1 (ABL proto-oncogene 1) • SPATS2L (Spermatogenesis Associated Serine Rich 2 Like)

over2years

A surrogate molecular approach for the detection of Philadelphia chromosome-like B-acute lymphoblastic leukemia. (PubMed, Cancer)

Identification of recurrent gene abnormalities (RGA) B-acute lymphoblastic leukemia (B-ALL) cases using multiplex-reverse transcriptase polymerase chain reaction. Identification and characterization of Philadelphia (Ph)-like ALL cases using nCounter NanoString gene expression profiling and fluorescence in situ hybridization. Furthermore, Ph-like ALL cases were characterized according to CRLF2 expression and kinase-activating genomic alterations. Minimal residual disease of Ph-like ALL cases were quantified using flow cytometry-minimal residual disease assay. A surrogate molecular approach was established to detect Ph-like ALL cases from low- and middle-income countries.

over 2 years ago

Journal

ABL1 (ABL proto-oncogene 1) • JAK2 (Janus kinase 2) • RUNX1 (RUNX Family Transcription Factor 1) • ETV6 (ETS Variant Transcription Factor 6) • CRLF2 (Cytokine Receptor Like Factor 2) • AFF1 (AF4/FMR2 Family Member 1) • TCF3 (Transcription Factor 3) • P2RY8 (P2Y Receptor Family Member 8) • PBX1 (PBX Homeobox 1) • MUC4 (Mucin 4, Cell Surface Associated) • CEACAM6 (CEA Cell Adhesion Molecule 6) • SPATS2L (Spermatogenesis Associated Serine Rich 2 Like)

CRLF2 rearrangement • MUC4 expression

over2years

Identification and validation of the optimal reference genes for standardizing the gene expression profiling diagnostic panel of Ph-like B-lineage acute lymphoblastic leukemia. (PubMed, Clin Exp Med)

Lastly, we performed a correlation analysis and found that the combination of EEF2, GAPDH, and PGK1 represents the best combination with a very high correlation in Ph-like ALL cases. This is the first report that shows EEF2, GAPDH, and PGK1 are the best HKG genes and can be used in the diagnostic panel of Ph-like ALL cases using qPCR at baseline diagnosis.

over 2 years ago

Journal

ABL1 (ABL proto-oncogene 1) • KEAP1 (Kelch Like ECH Associated Protein 1) • CRLF2 (Cytokine Receptor Like Factor 2) • B2M (Beta-2-microglobulin) • MUC4 (Mucin 4, Cell Surface Associated) • GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • PGK1 (Phosphoglycerate Kinase 1) • BMPR1B (Bone Morphogenetic Protein Receptor Type 1B) • SPATS2L (Spermatogenesis Associated Serine Rich 2 Like)

MUC4 expression