SPATA18 (Spermatogenesis Associated 18)

Our approach, which combines two tumoricidal methods, mitophagy inhibition and chemotherapy, could therefore represent a new strategy for BC treatment. Abbreviations: BC: breast cancer; DXR: doxorubicin; MFN1: mitofusin 1; MFN2: mitofusin 2; miRNA: micro RNA; NPs: nanoparticles; OMM: outer mitochondrial membrane; PINK1: PTEN induced kinase 1; SPATA18: spermatogenesis Associated 18; TBNC: triple negative breast cancer.

Mieap-deficient cells exhibit altered crista structure, leading to decreased respiration activity and ATP production in mitochondria. These results suggest that Mieap may form membrane-less organelles to compartmentalize and facilitate cardiolipin metabolism, thus potentially contributing to mitochondrial quality control.

We also illustrate the molecular characterization of four immune clusters, including endothelial cells, B cells, DCs, and immune depression subtype. In conclusion, this comprehensive proteogenomic study characterizes the molecular architecture and hallmarks from pre-invasive to invasive lung adenocarcinoma, guiding the way to a deeper understanding of the tumorigenesis and progression of this disease.

The normalization method based on tumour progression from early to late stages of cancer development revealed the heterogeneity of KIRC and identified three potential new subtypes with different prognoses. This could be of great importance for the development of new targeted therapies for each subtype.

In conclusion, this is the first integrated proteogenomic study to characterize the molecular architecture and hallmarks from pre-invasive to invasive lung adenocarcinoma, guiding a path to the prevention, early detection, and precise treatment of this disease.

Gene set enrichment analysis (GSEA) showed that B cell receptors, WNT targets, extracellular matrix, oxidative phosphorylation, calcium metabolism, iron uptake and transport, potassium channels, and insulin receptor were differently enriched in the phenotype that was negatively correlated with SPATA18. CONCLUSIONS Our study indicated that high SPATA18 expression in ccRCC was associated with a good prognosis, and it could be a positive prognostic biomarker for ccRCC.

In conclusion, we established a nomogram based on six DNA methylation-driven genes with excellent accuracy for prognostic prediction in ccRCC patients. This nomogram model might provide novel insights into the epigenetic mechanism and individualized treatment of ccRCC.

This indicates that during the generation of doxorubicin resistance, cells acquire genetic changes likely to be random, leading to down regulation of TOP2A, but selected during the generation of cells due to the presence of drug in the culture medium. This poses a considerable constraint for the development of strategies aimed at avoiding the emergence of drug resistance in the clinic.